Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Dimitrios T Trafalis"'
Autor:
Ioannis Anestopoulos, Ioannis Paraskevaidis, Sotiris Kyriakou, Lambrini E. Giova, Dimitrios T. Trafalis, Sotiris Botaitis, Rodrigo Franco, Aglaia Pappa, Mihalis I. Panayiotidis
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 2745 (2024)
In this study, we utilized an in vitro model consisting of human malignant melanoma as well as non-tumorigenic immortalized keratinocyte cells with the aim of characterizing the therapeutic effectiveness of the clinical epigenetic drug Tazemetostat a
Externí odkaz:
https://doaj.org/article/e8e1e020d2b84d4e8491814b20a58b7e
Autor:
Kyriakos Orfanakos, Constantinos E. Alifieris, Emmanouil K. Verigos, Maria V. Deligiorgi, Kosmas E. Verigos, Mihalis I. Panayiotidis, Michail Nikolaou, Dimitrios T. Trafalis
Publikováno v:
Biomedicines, Vol 12, Iss 1, p 134 (2024)
Ionizing radiation is strongly linked to direct or indirect DNA damage, as with the production of reactive oxygen species (ROS), which in turn produce DNA damage products, such as 8-hydroxy-2-deoxyguanosine (8-OHdG). In this study, we aimed to invest
Externí odkaz:
https://doaj.org/article/f2499422487240ebaccf384e53379e45
Autor:
Maria Voura, Saleha Anwar, Savvas Thysiadis, Parvez Κhan, Panagiotis Dalezis, Dimitrios T. Trafalis, Md Imtaiyaz Hassan, Vasiliki Sarli
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 6, Iss , Pp 100076- (2022)
Bisindole alkaloids are well-known bioactive natural products presenting numerous pharmacological properties. Following the indolocarbazole biosynthetic pathway a series of bisindole derivatives were synthesized and their activity against MARK4 kinas
Externí odkaz:
https://doaj.org/article/74463cce4fcb4dff97a900123f2859bb
Autor:
Sotiris Kyriakou, Kyriaki Michailidou, Tom Amery, Kyle Stewart, Paul G. Winyard, Dimitrios T. Trafalis, Rodrigo Franco, Aglaia Pappa, Mihalis I. Panayiotidis
Publikováno v:
Frontiers in Plant Science, Vol 13 (2022)
Watercress (Nasturtium officinale) is a rich source of secondary metabolites with disease-preventing and/or health-promoting properties. Herein, we have utilized extraction procedures to isolate fractions of polyphenols, glucosinolates and isothiocya
Externí odkaz:
https://doaj.org/article/bc058b1b57d64b9e85f7fad606de1873
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7630 (2023)
The rubric of immune-related (ir) diabetes mellitus (DM) (irDM) encompasses various hyperglycemic disorders related to immune checkpoint inhibitors (ICPis). Beyond sharing similarities with conventional DM, irDM is a distinct, yet important, entity.
Externí odkaz:
https://doaj.org/article/2bb9e1b3403a40f8aded042fdd871b57
Autor:
Sotiris Kyriakou, Venetia Tragkola, Ioannis Paraskevaidis, Mihalis Plioukas, Dimitrios T. Trafalis, Rodrigo Franco, Aglaia Pappa, Mihalis I. Panayiotidis
Publikováno v:
Plants, Vol 12, Iss 8, p 1590 (2023)
Malignant melanoma is an aggressive type of skin cancer characterised by high metastatic capacity and mortality rate. On the other hand, Epilobium parviflorum is known for its medicinal properties, including its anticancer potency. In this context, w
Externí odkaz:
https://doaj.org/article/4d7ef4ce73a5491a96acb88eb79b9dee
Autor:
Despoina Varna, Elena Geromichalou, Georgia Karlioti, Rigini Papi, Panagiotis Dalezis, Antonios G. Hatzidimitriou, George Psomas, Theodora Choli-Papadopoulou, Dimitrios T. Trafalis, Panagiotis A. Angaridis
Publikováno v:
Molecules, Vol 28, Iss 1, p 336 (2023)
Ag(I) coordination compounds have recently attracted much attention as antiproliferative and antibacterial agents against a wide range of cancer cell lines and pathogens. The bioactivity potential of these complexes depends on their structural charac
Externí odkaz:
https://doaj.org/article/bcded383d9c748109e4bc5ebda480d74
Autor:
Georgios Charitos, Dimitrios T. Trafalis, Panayiotis Dalezis, Constantinos Potamitis, Vasiliki Sarli, Panagiotis Zoumpoulakis, Charalambos Camoutsis
Publikováno v:
Arabian Journal of Chemistry, Vol 12, Iss 8, Pp 4784-4794 (2019)
The development of new antitumor agents is one of the most pressing research areas in medicinal chemistry and medicine. The importance of triazole and thiadiazole rings as scaffolds present in a wide range of therapeutic agents has been well reported
Externí odkaz:
https://doaj.org/article/7701a1630fc541fdb94cb7f91e8ecc27
Autor:
Kosmas E. Verigos, Sofia Sagredou, Kyriakos Orfanakos, Panayiotis Dalezis, Dimitrios T. Trafalis
Publikováno v:
Dose-Response, Vol 18 (2020)
It is widely known that ionizing irradiation is strongly linked to the production of reactive oxygen (ROS) and nitrative species (RNS) through which DNA damage products like 8-hydroxy-2-deoxyguanosine (8-OHdG) and 8-nitroguanine (8-NG) are generated,
Externí odkaz:
https://doaj.org/article/a285508f5a734319bda32afb3327fc7f
Autor:
Sotiris Kyriakou, Dimitrios T. Trafalis, Maria V. Deligiorgi, Rodrigo Franco, Aglaia Pappa, Mihalis I. Panayiotidis
Publikováno v:
Antioxidants, Vol 11, Iss 4, p 642 (2022)
Isothiocyanates are biologically active secondary metabolites liberated via enzymatic hydrolysis of their sulfur enriched precursors, glucosinolates, upon tissue plant disruption. The importance of this class of compounds lies in their capacity to in
Externí odkaz:
https://doaj.org/article/89685edcb49149e686987a71a2dda3c6