Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Dimitrios Ilias Balourdas"'
Autor:
Nikolaos Antoniou, Nefeli Lagopati, Dimitrios Ilias Balourdas, Michail Nikolaou, Alexandros Papalampros, Panagiotis V. S. Vasileiou, Vassilios Myrianthopoulos, Athanassios Kotsinas, Yosef Shiloh, Michalis Liontos, Vassilis G. Gorgoulis
Publikováno v:
Cancers, Vol 12, Iss 1, p 62 (2019)
The genome is exposed daily to many deleterious factors. Ubiquitination is a mechanism that regulates several crucial cellular functions, allowing cells to react upon various stimuli in order to preserve their homeostasis. Ubiquitin ligases act as sp
Externí odkaz:
https://doaj.org/article/e6bbfc767026423aab8de1ce688fa7b0
Autor:
Dimitrios-Ilias Balourdas, Anja M. Markl, Andreas Krämer, Giovanni Settanni, Andreas C. Joerger
Publikováno v:
Cell Death and Disease, Vol 15, Iss 6, Pp 1-10 (2024)
Summary The cavity-creating p53 cancer mutation Y220C is an ideal paradigm for developing small-molecule drugs based on protein stabilization. Here, we have systematically analyzed the structural and stability effects of all oncogenic Tyr-to-Cys muta
Externí odkaz:
https://doaj.org/article/dd8940d56202490db948231012d59ebd
Autor:
Qiang Zhang, Dimitrios-Ilias Balourdas, Bruno Baron, Alon Senitzki, Tali E. Haran, Klas G. Wiman, Thierry Soussi, Andreas C. Joerger
Publikováno v:
Cell Death and Disease, Vol 13, Iss 3, Pp 1-11 (2022)
Abstract The extremophile Alvinella pompejana, an annelid worm living on the edge of hydrothermal vents in the Pacific Ocean, is an excellent model system for studying factors that govern protein stability. Low intrinsic stability is a crucial factor
Externí odkaz:
https://doaj.org/article/6293f38a3c7d4577850a7e1f3760078f
Autor:
Marcel Rak, Roberta Tesch, Lena M. Berger, Ekaterina Shevchenko, Monika Raab, Amelie Tjaden, Rezart Zhubi, Dimitrios-Ilias Balourdas, Andreas C. Joerger, Antti Poso, Andreas Krämer, Lewis Elson, Aleksandar Lučić, Thales Kronenberger, Thomas Hanke, Klaus Strebhardt, Mourad Sanhaji, Stefan Knapp
Salt-inducible kinases 1-3 (SIK1-3) are key regulators of the LKB1-AMPK pathway and play an important role in cellular homeostasis. Dysregulation of any of the three isoforms has been associated with tumorigenesis in liver, breast, and ovarian cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::464dad30e9b231cf6faf66b9ea226da4
https://doi.org/10.1101/2023.03.24.534094
https://doi.org/10.1101/2023.03.24.534094
Autor:
Julianne Funk, Maria Klimovich, Evangelos Pavlakis, Michelle Neumann, Daniel Drangenstein, Maxim Noeparast, Pascal Hunold, Anna Borowek, Dimitrios-Ilias Balourdas, Katharina Kochhan, Nastasja Merle, Imke Bullwinkel, Michael Wanzel, Sabrina Elmshäuser, Andrea Nist, Tara Procida, Marek Bartkuhn, Katharina Humpert, Marco Mernberger, Rajkumar Savai, Andreas C. Joerger, Thorsten Stiewe
The tumor suppressor geneTP53is the most frequently mutated gene in various cancers. Unlike other tumor suppressors,TP53is mostly hit by missense mutations, of which more than 2,000 have been described in cancer patients. To take advantage ofTP53muta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bd897fd30da296ebc5a45f07280c622
https://doi.org/10.1101/2023.03.10.531074
https://doi.org/10.1101/2023.03.10.531074
Autor:
Maëva Pichon, Dawid Drelinkiewicz, David Lozano, Ruxandra Moraru, Laura Hayward, Megan Jones, Michael Mccoy, Samuel Allstrum-Graves, Dimitrios-Ilias Balourdas, Andreas Joerger, Richard Whitby, Stephen Goldup, Neil Wells, Graham Langley, Julie Herniman, Matthias Baud
Protein arylation has attracted much attention for developing new classes of bioconjugates with improved properties. Here, we have systematically evaluated 2-sulfonylpyrimidines as covalent warheads for the mild, chemoselective and metal free cystein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bf8339c15ca0415059b4ae2afbbb7bb
https://doi.org/10.26434/chemrxiv-2023-cx8vk
https://doi.org/10.26434/chemrxiv-2023-cx8vk
Autor:
Joseph R. Stephenson Clarke, Leon R. Douglas, Patrick J. Duriez, Dimitrios-Ilias Balourdas, Andreas C. Joerger, Raniya Khadiullina, Emil Bulatov, Matthias G. J. Baud
Publikováno v:
ACS pharmacologytranslational science. 5(11)
The tumor suppressor protein p53 is inactivated in the majority of human cancers and remains a prime target for developing new drugs to reactivate its tumor suppressing activity for anticancer therapies. The oncogenic p53 mutant Y220C accounts for ap
Autor:
Vassilios Myrianthopoulos, Michail Nikolaou, Panagiotis Vasileiou, Michalis Liontos, Vassilis G. Gorgoulis, Nefeli Lagopati, Yosef Shiloh, Dimitrios Ilias Balourdas, Alexandros Papalampros, N. G. Antoniou, Athanassios Kotsinas
Publikováno v:
Cancers
Cancers, Vol 12, Iss 1, p 62 (2019)
Cancers, Vol 12, Iss 1, p 62 (2019)
The genome is exposed daily to many deleterious factors. Ubiquitination is a mechanism that regulates several crucial cellular functions, allowing cells to react upon various stimuli in order to preserve their homeostasis. Ubiquitin ligases act as sp
Autor:
Grigoris Zoidis, Kata Mlinarić-Majerski, John M. Kelly, Martin C. Taylor, Dimitrios-Ilias Balourdas, Marina Šekutor, Vasiliki Pardali, Erofili Giannakopoulou, Vassilios Myrianthopoulos
Publikováno v:
Current pharmaceutical design. 26(8)
In this report, we extend the SAR analysis of a number of lipophilic guanylhydrazone analogues with respect to in vitro growth inhibition of Trypanosoma brucei and Trypanosoma cruzi. Sleeping sickness and Chagas disease, caused by the tropical parasi