Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Dimitrios Evangelopoulos"'
Autor:
Tulika Munshi, Antima Gupta, Dimitrios Evangelopoulos, Juan David Guzman, Simon Gibbons, Nicholas H Keep, Sanjib Bhakta
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0301375 (2024)
[This corrects the article DOI: 10.1371/journal.pone.0060143.].
Externí odkaz:
https://doaj.org/article/15b54048e72b4670b65c82cfd7fc2977
Autor:
Dimitrios Evangelopoulos, Gareth A. Prosser, Angela Rodgers, Belinda M. Dagg, Bhagwati Khatri, Mei Mei Ho, Maximiliano G. Gutierrez, Teresa Cortes, Luiz Pedro S. de Carvalho
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
D-cycloserine (DCS) has been used for decades to treat Mycobacterium tuberculosis (Mtb) but resistance is rarely observed in clinical isolates. Here, the authors report ultra-low rate of emergence of resistance mutations as the underlying mechanism o
Externí odkaz:
https://doaj.org/article/cd1574c81b52465e9b1150a6fda379b5
Autor:
Dimitrios Evangelopoulos, Carolyn M. Shoen, Isobella Honeyborne, Simon Clark, Ann Williams, Galina V. Mukamolova, Michael H. Cynamon, Timothy D. McHugh
Publikováno v:
Microorganisms, Vol 10, Iss 2, p 460 (2022)
Background: The turnaround times for phenotypic tests used to monitor the bacterial load of Mycobacterium tuberculosis, in both clinical and preclinical studies, are delayed by the organism’s slow growth in culture media. The existence of different
Externí odkaz:
https://doaj.org/article/5fa519d82f534e0fbbfa23ebf78f3c2c
Autor:
Cynthia A. Danquah, Eleftheria Kakagianni, Proma Khondkar, Arundhati Maitra, Mukhlesur Rahman, Dimitrios Evangelopoulos, Timothy D. McHugh, Paul Stapleton, John Malkinson, Sanjib Bhakta, Simon Gibbons
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
Abstract Disulfides from Allium stipitatum, commonly known as Persian shallot, were previously reported to possess antibacterial properties. Analogues of these compounds, produced by S-methylthiolation of appropriate thiols using S-methyl methanethio
Externí odkaz:
https://doaj.org/article/37e1ab0ec36449f69d577c41c3e6f546
Autor:
Eleni Pappa, Michael Michalos, Konstantinos Zisis, George Koundis, Constantine Kokoroghiannis, Dimitrios Evangelopoulos
Publikováno v:
Clinical Case Reports, Vol 8, Iss 12, Pp 3603-3604 (2020)
Abstract The present case is unique in that the fracture of the posteromedial talar tubercule involved the tibiotalar rather than the subtalar joint as described in existing reports, which underlines the need for acute management by the Orthopaedic S
Externí odkaz:
https://doaj.org/article/c1b027af81c644a384a86f6200845265
Autor:
Sarentha Chetty, Tom Armstrong, Shalu Sharma Kharkwal, William C. Drewe, Cristina I. De Matteis, Dimitrios Evangelopoulos, Sanjib Bhakta, Neil R. Thomas
Publikováno v:
Pharmaceuticals, Vol 14, Iss 4, p 361 (2021)
The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) has reinforced the need for the development of new anti-TB drugs. The first line drug isoniazid inhibits InhA. This is a prodrug requiring activation by
Externí odkaz:
https://doaj.org/article/0a04b1c8e4eb420481d6dc6e82ba0b62
Publikováno v:
International Journal of Infectious Diseases, Vol 32, Iss C, Pp 76-80 (2015)
Tuberculosis still remains a global health emergency, claiming 1.5 million lives in 2013. The bacterium responsible for this disease, Mycobacterium tuberculosis (M.tb), has successfully survived within hostile host environments, adapting to immune de
Externí odkaz:
https://doaj.org/article/3ac00eb0ecac444ba2c8a920ce8165c2
Autor:
Tulika Munshi, Antima Gupta, Dimitrios Evangelopoulos, Juan David Guzman, Simon Gibbons, Nicholas H Keep, Sanjib Bhakta
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e60143 (2013)
ATP-dependent Mur ligases (Mur synthetases) play essential roles in the biosynthesis of cell wall peptidoglycan (PG) as they catalyze the ligation of key amino acid residues to the stem peptide at the expense of ATP hydrolysis, thus representing pote
Externí odkaz:
https://doaj.org/article/e53b97656f6d45629eaee5ee1422a075
Autor:
Martyn Frederickson, Irwin R. Selvam, Dimitrios Evangelopoulos, Kirsty J. McLean, Mona M. Katariya, Richard B. Tunnicliffe, Bethany Campbell, Madeline E. Kavanagh, Sitthivut Charoensutthivarakul, Richard T. Blankley, Colin W. Levy, Luiz Pedro S. de Carvalho, David Leys, Andrew W. Munro, Anthony G. Coyne, Chris Abell
Publikováno v:
Frederickson, M, Selvam, I R, Evangelopoulos, D, McLean, K J, Katariya, M M, Tunnicliffe, R B, Campbell, B, Kavanagh, M E, Charoensutthivarakul, S, Blankley, R T, Levy, C W, de Carvalho, L P S, Leys, D, Munro, A W, Coyne, A G & Abell, C 2022, ' A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen) ', European Journal of Medicinal Chemistry, vol. 230, 114105 . https://doi.org/10.1016/j.ejmech.2022.114105
There is a pressing need for new drugs against tuberculosis (TB) to combat the growing resistance to current antituberculars. Herein a novel strategy is described for hit generation against promising TB targets involving X-ray crystallographic screen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6d9c2705833bafc4766f5cadaceb345
Autor:
Dimitrios, Evangelopoulos, Carolyn M, Shoen, Isobella, Honeyborne, Simon, Clark, Ann, Williams, Galina V, Mukamolova, Michael H, Cynamon, Timothy D, McHugh
Publikováno v:
Microorganisms. 10(2)
The turnaround times for phenotypic tests used to monitor the bacterial load ofWe report the adaptation of our robust, culture-free assay utilising 16S ribosomal RNA, developed for sputum, to enumerate the number of bacteria present in animal tissues