Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Dimitrios Cakouros"'
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6499 (2023)
Many crucial epigenetic changes occur during early skeletal development and throughout life due to aging, disease and are heavily influenced by an individual’s lifestyle. Epigenetics is the study of heritable changes in gene expression as the resul
Externí odkaz:
https://doaj.org/article/7cd6665bc59240488ab14c0c6555b9d2
Autor:
Clara Pribadi, Esther Camp, Dimitrios Cakouros, Peter Anderson, Carlotta Glackin, Stan Gronthos
Publikováno v:
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-14 (2020)
Abstract Background During development, excessive osteogenic differentiation of mesenchymal progenitor cells (MPC) within the cranial sutures can lead to premature suture fusion or craniosynostosis, leading to craniofacial and cognitive issues. Saeth
Externí odkaz:
https://doaj.org/article/51aeed292f3547cbbdf4a3e648187f43
Autor:
Dimitrios Cakouros, Sarah Hemming, Kahlia Gronthos, Renjing Liu, Andrew Zannettino, Songtao Shi, Stan Gronthos
Publikováno v:
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-20 (2019)
Abstract Background The 5 hydroxymethylation (5hmC) mark and TET DNA dioxygenases play a pivotal role in embryonic stem cell differentiation and animal development. However, very little is known about TET enzymes in lineage determination of human bon
Externí odkaz:
https://doaj.org/article/3a6a75508e6042c89322bdc67e374dcb
Autor:
Monika M. Kutyna, Chung Hoow Kok, Yoon Lim, Elizabeth Ngoc Hoa Tran, David Campbell, Sharon Paton, Chloe Thompson-Peach, Kelly Lim, Dimitrios Cakouros, Agnes Arthur, Timothy Hughes, Sharad Kumar, Daniel Thomas, Stan Gronthos, Devendra K. Hiwase
Publikováno v:
Leukemia. 36:2678-2689
Therapy-related myeloid neoplasm (tMN) is considered a direct consequence of DNA damage in hematopoietic stem cells. Despite increasing recognition that altered stroma can also drive leukemogenesis, the functional biology of the tMN microenvironment
Publikováno v:
Stem Cells and Development.
Autor:
Dimitrios Cakouros, Stan Gronthos
Publikováno v:
Current Osteoporosis Reports
Purpose of ReviewAlthough many signalling pathways have been discovered to be essential in mesenchymal stem/stromal (MSC) differentiation, it has become increasingly clear in recent years that epigenetic regulation of gene transcription is a vital co
Autor:
Stan Gronthos, Peter J. Anderson, Clara Pribadi, Dimitrios Cakouros, Esther Camp, Carlotta A. Glackin
Publikováno v:
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-14 (2020)
Stem Cell Research & Therapy
Stem Cell Research & Therapy
BackgroundDuring development, excessive osteogenic differentiation of mesenchymal progenitor cells (MPC) within the cranial sutures can lead to premature suture fusion or craniosynostosis, leading to craniofacial and cognitive issues. Saethre-Chotzen
Autor:
Stan Gronthos, Dimitrios Cakouros
Publikováno v:
Bone. 137
There is mounting evidence in the literature that mesenchymal stromal/stem cell (MSC) like populations derived from different tissues, undergo epigenetic changes during aging, leading to compromised connective tissue integrity and function. This body
Autor:
Sharon Paton, Monika M Kutyna, Devendra K Hiwase, Dimitrios Cakouros, Timothy P. Hughes, Chung H. Kok, David G. Campbell, Agnieszka Arthur, Stan Gronthos, Daniel Thomas
Publikováno v:
Blood. 138:2585-2585
Background: Therapy-related myeloid neoplasms (tMN) is a second haematological malignancy associated with distinct molecular profile (Singhal et al Leukemia 2019) and dismal outcome. tMN is believed to arise from cytotoxic DNA damage to haematopoieti
Autor:
Andreas W. Schreiber, David G. Campbell, Timothy P. Hughes, Sharon Paton, Deepak Singhal, Agnieszka Arthur, Stan Gronthos, Chung H. Kok, Dimitrios Cakouros, Rakchha Chhetri, Monika M Kutyna, Daniel Thomas, Li Yan A Wee, Devendra K Hiwase
Publikováno v:
Blood. 136:37-38
Introduction: Therapy-related myeloid neoplasms (t-MN) are associated with extremely poor clinical outcomes in otherwise long-term cancer survivors. t-MN accounts for ~20% of cases of myeloid neoplasms and is expected to rise due to the increased use