Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Dimitrios Arkilo"'
Autor:
Nitin Agarwal, Dimitrios Arkilo, Osman Farooq, Cynthia Gillogly, Katelyn S Kavak, Arie Weinstock
Publikováno v:
SAGE Open Medicine, Vol 5 (2017)
Background: The ketogenic diet is an effective non-pharmacologic treatment for medically resistant epilepsy. The aim of this study was to identify any predictors that may influence the response of ketogenic diet. Methods: A retrospective chart review
Externí odkaz:
https://doaj.org/article/0a6252fd7d62483bbe696658a555f798
Publikováno v:
Case Reports in Neurological Medicine, Vol 2015 (2015)
A 15-year-old girl with maternal inheritance of neurofibromatosis type 1 (NF1) and paternal inheritance of tuberous sclerosis complex (TSC) developed intractable epilepsy at age 5. Her seizures were refractory to adequate doses of four antiepileptic
Externí odkaz:
https://doaj.org/article/3bc336eb4ea14ccca9d814c9717a28ea
Autor:
Cecil D. Hahn, Yuwu Jiang, Vicente Villanueva, Marta Zolnowska, Dimitrios Arkilo, Samuel Hsiao, Mahnaz Asgharnejad, Dennis Dlugos
Publikováno v:
EpilepsiaREFERENCES. 63(10)
Dravet syndrome (DS) and Lennox-Gastaut syndrome (LGS) are rare treatment-resistant childhood epilepsies classed as developmental and epileptic encephalopathies. ELEKTRA investigated the efficacy and safety of soticlestat (TAK-935) as adjunctive ther
Autor:
Scott Demarest, Shafali Jeste, Nitin Agarwal, Dimitrios Arkilo, Mahnaz Asgharnejad, Samuel Hsiao, Ronald Thibert
Publikováno v:
Epilepsy & Behavior. 142:109173
Autor:
Polyna Khudyakov, Maria S. Quinton, Wei Yin, Saurabh Gupta, Deborah S. Hartman, Dimitrios Arkilo, Jie Lin, Laura Rosen, Jens R. Wendland, Jim Hazel, Martin M. Bednar
Publikováno v:
British Journal of Clinical Pharmacology. 87:4756-4768
Aims Dysregulation of histone methylation epigenetic marks may result in intellectual and developmental disability, as seen in Kabuki syndrome. Animal data suggest that increasing histone methylation by inhibiting lysine-specific demethylase 1A (LSD1
Autor:
Stuart Ratcliffe, Dimitrios Arkilo, Mahnaz Asgharnejad, Sudipta Bhattacharya, R Norman Harden
Publikováno v:
Pain medicine (Malden, Mass.).
Objective The objective was to investigate the efficacy and safety of soticlestat as adjunctive therapy in participants with complex regional pain syndrome (CRPS). Design A proof-of-concept phase 2a study, comprising a 15-week randomized, double-blin
Autor:
Wei Yin, David Han, Polyna Khudyakov, Rhett Behrje, Joel Posener, Antonio Laurenza, Dimitrios Arkilo
Publikováno v:
British journal of clinical pharmacology. 88(8)
TAK-041 (NBI-1065846), an orally available, investigational, small molecule agonist of GPR139, an orphan G-protein-coupled receptor, has shown promise in preclinical studies for the treatment of symptoms associated with schizophrenia. Here, we report
Autor:
Jonathan J. Halford, Mahnaz Asgharnejad, Celia Zinger, Dimitrios Arkilo, Matthew During, Jacqueline A. French, Michael R. Sperling, Rengyi Xu
Publikováno v:
Epilepsy research. 174
Objective To evaluate the safety, tolerability, and pharmacokinetics of soticlestat, a first-in-class cholesterol 24-hydroxylase inhibitor, in adults with developmental and/or epileptic encephalopathies (DEE). Methods The study comprised a 30-day, ra
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 49(2)
Hepatic metabolism of low-clearance compound TAK-041 was studied in two different in vitro model systems using rat, dog, monkey, and human suspended cryopreserved hepatocytes and HepatoPac micropatterned coculture model primary hepatocytes. The aim o
Publikováno v:
European Journal of Paediatric Neurology. 20:212-217
Objective To review our clinical experience with intravenous (iv) lacosamide (LCM) in children less than 12 years old. Background Use of LCM to treat children with epilepsy has been supported by multiple studies with limited information on iv use in