Correction: Characterisation of ATP-Dependent Mur Ligases Involved in the Biogenesis of Cell Wall Peptidoglycan in Mycobacterium tuberculosis.

Autor: Tulika Munshi, Antima Gupta, Dimitrios Evangelopoulos, Juan David Guzman, Simon Gibbons, Nicholas H Keep, Sanjib Bhakta

Publikováno v: PLoS ONE, Vol 19, Iss 3, p e0301375 (2024)

[This corrects the article DOI: 10.1371/journal.pone.0060143.].

Externí odkaz: https://doaj.org/article/15b54048e72b4670b65c82cfd7fc2977

Culture-Free Enumeration of Mycobacterium tuberculosis in Mouse Tissues Using the Molecular Bacterial Load Assay for Preclinical Drug Development

Autor: Dimitrios Evangelopoulos, Carolyn M. Shoen, Isobella Honeyborne, Simon Clark, Ann Williams, Galina V. Mukamolova, Michael H. Cynamon, Timothy D. McHugh

Publikováno v: Microorganisms, Vol 10, Iss 2, p 460 (2022)

Background: The turnaround times for phenotypic tests used to monitor the bacterial load of Mycobacterium tuberculosis, in both clinical and preclinical studies, are delayed by the organism’s slow growth in culture media. The existence of different

Externí odkaz: https://doaj.org/article/5fa519d82f534e0fbbfa23ebf78f3c2c

Unusual posteromedial tubercle fracture extending to the talar dome

Autor: Eleni Pappa, Michael Michalos, Konstantinos Zisis, George Koundis, Constantine Kokoroghiannis, Dimitrios Evangelopoulos

Publikováno v: Clinical Case Reports, Vol 8, Iss 12, Pp 3603-3604 (2020)

Abstract The present case is unique in that the fracture of the posteromedial talar tubercule involved the tibiotalar rather than the subtalar joint as described in existing reports, which underlines the need for acute management by the Orthopaedic S

Externí odkaz: https://doaj.org/article/c1b027af81c644a384a86f6200845265

Understanding anti-tuberculosis drug efficacy: rethinking bacterial populations and how we model them

Autor: Dimitrios Evangelopoulos, Joana Diniz da Fonseca, Simon J. Waddell

Publikováno v: International Journal of Infectious Diseases, Vol 32, Iss C, Pp 76-80 (2015)

Tuberculosis still remains a global health emergency, claiming 1.5 million lives in 2013. The bacterium responsible for this disease, Mycobacterium tuberculosis (M.tb), has successfully survived within hostile host environments, adapting to immune de

Externí odkaz: https://doaj.org/article/3ac00eb0ecac444ba2c8a920ce8165c2

A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen)

Autor: Martyn Frederickson, Irwin R. Selvam, Dimitrios Evangelopoulos, Kirsty J. McLean, Mona M. Katariya, Richard B. Tunnicliffe, Bethany Campbell, Madeline E. Kavanagh, Sitthivut Charoensutthivarakul, Richard T. Blankley, Colin W. Levy, Luiz Pedro S. de Carvalho, David Leys, Andrew W. Munro, Anthony G. Coyne, Chris Abell

Publikováno v: Frederickson, M, Selvam, I R, Evangelopoulos, D, McLean, K J, Katariya, M M, Tunnicliffe, R B, Campbell, B, Kavanagh, M E, Charoensutthivarakul, S, Blankley, R T, Levy, C W, de Carvalho, L P S, Leys, D, Munro, A W, Coyne, A G & Abell, C 2022, ' A new strategy for hit generation: Novel in cellulo active inhibitors of CYP121A1 from Mycobacterium tuberculosis via a combined X-ray crystallographic and phenotypic screening approach (XP screen) ', European Journal of Medicinal Chemistry, vol. 230, 114105 . https://doi.org/10.1016/j.ejmech.2022.114105

There is a pressing need for new drugs against tuberculosis (TB) to combat the growing resistance to current antituberculars. Herein a novel strategy is described for hit generation against promising TB targets involving X-ray crystallographic screen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6d9c2705833bafc4766f5cadaceb345