Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Dimitri Ott"'
Autor:
Theodoros Karagiannis, Mathäus Niemietz, Carlo Unverzagt, Mónica Martínez-Orts, Marie Lott, Nahid Razi, James C. Paulson, Dimitri Ott, Steffen Eller, Ángeles Canales, Markus Weishaupt, Michael Weiss
Publikováno v:
Chembiochem
In human serum immunoglobulin G (IgG), a rare modification of biantennary complex N‐glycans lead to a β1,4‐galactosylated bisecting GlcNAc branch. We found that the bisecting GlcNAc on a biantennary core‐fucosylated N‐glycan was enzymaticall
Autor:
Cathrin Wirkner, Janika Walcher, Matthias Pischl, Joanna Hoffman, Dimitri Ott, Manuel Mönnich, Markus Weishaupt, Theodoros Karagiannis, Carlo Unverzagt, Rachel G. Lichtenstein, Lukas Perkams, Mathäus Niemietz, Lukas Berger, Thomas Luber, Steffen Eller
Publikováno v:
Angewandte Chemie. 128:10643-10648
Die Gegenwart von N-Glycanen mit einer bisecting GlcNAc-Modifikation auf Glycoproteinen hat viele Auswirkungen in der Entwicklungs- und Immunbiologie. Allerdings ist es schwierig diese N-Glycane aus der Natur oder durch Synthese zu erhalten. Fur bise
Autor:
Dimitri Ott, Manuel Mönnich, Joanna Hoffman, Matthias Pischl, Markus Weishaupt, Lukas Berger, Theodoros Karagiannis, Mathäus Niemietz, Janika Walcher, Carlo Unverzagt, Lukas Perkams, Thomas Luber, Steffen Eller
Publikováno v:
Angewandte Chemie (International ed. in English). 57(44)
The occurrence of α1,6-linked core fucose on the N-glycans of mammalian glycoproteins is involved in tumor progression and reduces the bioactivity of antibodies in antibody-dependent cell-mediated cytotoxicity (ADCC). Since core-fucosylated N-glycan
Autor:
Markus Weishaupt, Manuel Mönnich, Joanna Hoffman, Janika Walcher, Lukas Perkams, Thomas Luber, Matthias Pischl, Dimitri Ott, Carlo Unverzagt, Lukas Berger, Theodoros Karagiannis, Mathäus Niemietz, Cathrin Wirkner, Steffen Eller, Rachel G. Lichtenstein
Publikováno v:
Angewandte Chemie (International ed. in English). 55(35)
The occurrence of N-glycans with a bisecting GlcNAc modification on glycoproteins has many implications in developmental and immune biology. However, these particular N-glycans are difficult to obtain either from nature or through synthesis. We have
Autor:
Manuel Mönnich, Joachim Seifert, Carlo Unverzagt, Janna Guder, Ingo Prahl, Mathäus Niemietz, Dimitri Ott, Joanna Hoffman
Publikováno v:
European Journal of Organic Chemistry. 2012:5054-5068
A modular synthesis of complex-type N-glycans containing the core fucosyl motif was optimized. The core trisaccharide building block was protected by a methoxyphenyl group for convenient core fucosylation. The trisaccharide was obtained on a large sc
Autor:
Lars-Oliver Essen, Stefan Brückner, Maik Veelders, Dimitri Ott, Carlo Unverzagt, Hans-Ulrich Mösch
Publikováno v:
Proceedings of the National Academy of Sciences. 107:22511-22516
In the budding yeast Saccharomyces cerevisiae , self-recognition and the thereby promoted aggregation of thousands of cells into protective flocs is mediated by a family of cell-surface adhesins, the flocculins (Flo). Based on this social behavior FL
Autor:
Regina Heidenreich, Katrin Kinkel, Frank Totzke, Stefan Laufer, Dieter Schollmeyer, Dimitri Ott, Christian Peifer, Martin Röcken, Christoph Schächtele, Roland Selig
Publikováno v:
Journal of Medicinal Chemistry. 51:3814-3824
In this study we report on the design, synthesis, and biological evaluation of pyrrole-2-one 2 to be a highly potent VEGF-R2/3 inhibitor with IC 50 of 31/37 nM. The novel 3,4-diaryl-2 H-pyrrole-2-ones were designed on the basis of the modeled binding
Autor:
Niels-Christian Reichardt, Kyria S. Nascimento, Dimitri Ott, Janika Walcher, Annabelle Varrot, Carlo Unverzagt, Alexandre Holanda Sampaio, Anne Imberty, Antônia Sâmia Fernandes do Nascimento, Sonia Serna, Jesús Jiménez-Barbero, Benildo Sousa Cavada, Ana Ardá, Ana Beloqui
Publikováno v:
Glycobiology. 25(6)
We determined the specificity of BTL, a lectin from the red marine alga Bryothamnion triquetrum, toward fucosylated oligosaccharides. BTL showed a strict specificity for the core α1,6-fucosylation, which is an important marker for cancerogenesis and
Publikováno v:
Acta Crystallographica Section E Structure Reports Online. 63:o1415-o1417
The crystal structure of the title compound, C20H18N2O3, was determined in the course of our studies of the synthesis of 3-acylindole derivatives. We obtained it as an unexpected racemic side product. The crystal structure contains chains of dimers a
Autor:
Christian Peifer, Roland Selig, Katrin Kinkel, Dimitri Ott, Frank Totzke, Christoph Schächtele, Regina Heidenreich, Martin Röcken, Dieter Schollmeyer, Stefan Laufer
Publikováno v:
Journal of Medicinal Chemistry; Jun2008, Vol. 51 Issue 13, p3814-3824, 11p