Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Dimitri Lavillette"'
Autor:
Shi Yu, Xu Zheng, Yanqiu Zhou, Yuhui Gao, Bingjie Zhou, Yapei Zhao, Tingting Li, Yunyi Li, Jiabin Mou, Xiaoxian Cui, Yuying Yang, Dianfan Li, Min Chen, Dimitri Lavillette, Guangxun Meng
Publikováno v:
PLoS Pathogens, Vol 19, Iss 11, p e1011789 (2023)
The COVID pandemic fueled by emerging SARS-CoV-2 new variants of concern remains a major global health concern, and the constantly emerging mutations present challenges to current therapeutics. The spike glycoprotein is not only essential for the ini
Externí odkaz:
https://doaj.org/article/95a69b5254724c368e17456771ac2be0
Autor:
Shiqi Xu, Yifan Wang, Yanxing Wang, Chao Zhang, Qin Hong, Chenjian Gu, Rong Xu, Tingfeng Wang, Yong Yang, Jinkai Zang, Yu Zhou, Zuyang Li, Qixing Liu, Bingjie Zhou, Lulu Bai, Yuanfei Zhu, Qiang Deng, Haikun Wang, Dimitri Lavillette, Gary Wong, Youhua Xie, Yao Cong, Zhong Huang
Publikováno v:
Emerging Microbes and Infections, Vol 11, Iss 1, Pp 351-367 (2022)
The emergence of multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern threatens the efficacy of currently approved vaccines and authorized therapeutic monoclonal antibodies (MAbs). It is hence important to continu
Externí odkaz:
https://doaj.org/article/ac5fe87d05474ecfa1a8ba797a0e8a24
Autor:
Lu Meng, Jialu Zha, Bingjie Zhou, Long Cao, Congli Jiang, Yuanfei Zhu, Teng Li, Lu Lu, Junqi Zhang, Heng Yang, Jian Feng, Zhifeng Gu, Hong Tang, Lubin Jiang, Dianfan Li, Dimitri Lavillette, Xiaoming Zhang
Publikováno v:
PLoS Pathogens, Vol 19, Iss 1, p e1011085 (2023)
Neutralizing antibodies (nAbs) are important assets to fight COVID-19, but most existing nAbs lose the activities against Omicron subvariants. Here, we report a human monoclonal antibody (Ab08) isolated from a convalescent patient infected with the p
Externí odkaz:
https://doaj.org/article/c5a977acb68c43f080f6da78d448a835
Autor:
Tingting Li, Hongmin Cai, Yapei Zhao, Yanfang Li, Yanling Lai, Hebang Yao, Liu Daisy Liu, Zhou Sun, Martje Fentener van Vlissingen, Thijs Kuiken, Corine H GeurtsvanKessel, Ning Zhang, Bingjie Zhou, Lu Lu, Yuhuan Gong, Wenming Qin, Moumita Mondal, Bowen Duan, Shiqi Xu, Audrey S Richard, Hervé Raoul, JianFeng Chen, Chenqi Xu, Ligang Wu, Haisheng Zhou, Zhong Huang, Xuechao Zhang, Jun Li, Yanyan Wang, Yuhai Bi, Barry Rockx, Junfang Chen, Fei‐Long Meng, Dimitri Lavillette, Dianfan Li
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 12, Pp 1-21 (2021)
Abstract An essential step for SARS‐CoV‐2 infection is the attachment to the host cell receptor by its Spike receptor‐binding domain (RBD). Most of the existing RBD‐targeting neutralizing antibodies block the receptor‐binding motif (RBM), a
Externí odkaz:
https://doaj.org/article/7f206b05d79247f4a77f570a14981163
Autor:
Tingting Li, Hongmin Cai, Hebang Yao, Bingjie Zhou, Ning Zhang, Martje Fentener van Vlissingen, Thijs Kuiken, Wenyu Han, Corine H. GeurtsvanKessel, Yuhuan Gong, Yapei Zhao, Quan Shen, Wenming Qin, Xiao-Xu Tian, Chao Peng, Yanling Lai, Yanxing Wang, Cedric A. J. Hutter, Shu-Ming Kuo, Juan Bao, Caixuan Liu, Yifan Wang, Audrey S. Richard, Hervé Raoul, Jiaming Lan, Markus A. Seeger, Yao Cong, Barry Rockx, Gary Wong, Yuhai Bi, Dimitri Lavillette, Dianfan Li
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Here, the authors report the engineering, structural and biological characterization of synthetic nanobodies (sybodies) that display potent therapeutic activity against SARS-CoV-2 infection in animal models via targeting the virus receptor-binding do
Externí odkaz:
https://doaj.org/article/e2d2ef9db7c042d5ae0d4a35e2484adb
Autor:
Tingting Li, Bingjie Zhou, Zhipu Luo, Yanling Lai, Suqiong Huang, Yuanze Zhou, Yaning Li, Anupriya Gautam, Salome Bourgeau, Shurui Wang, Juan Bao, Jingquan Tan, Dimitri Lavillette, Dianfan Li
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
SARS-CoV-2 and its variants, such as the Omicron continue to threaten public health. The virus recognizes the host cell by attaching its Spike (S) receptor-binding domain (RBD) to the host receptor, ACE2. Therefore, RBD is a primary target for neutra
Externí odkaz:
https://doaj.org/article/388b71d2aef845efbeb6a98de15c8137
Autor:
Jinkai Zang, Yannan Yin, Shiqi Xu, Weihua Qiao, Qiuyue Liu, Dimitri Lavillette, Chao Zhang, Haikun Wang, Zhong Huang
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The newly emerged Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contains more than 30 mutations on the spike protein, 15 of which are located within the receptor binding domain (RBD). Consequently, Omicron is able to
Externí odkaz:
https://doaj.org/article/c79f574437d3438f9165ec7eb0d2a672
Autor:
Chao Zhang, Yifan Wang, Yuanfei Zhu, Caixuan Liu, Chenjian Gu, Shiqi Xu, Yalei Wang, Yu Zhou, Yanxing Wang, Wenyu Han, Xiaoyu Hong, Yong Yang, Xueyang Zhang, Tingfeng Wang, Cong Xu, Qin Hong, Shutian Wang, Qiaoyu Zhao, Weihua Qiao, Jinkai Zang, Liangliang Kong, Fangfang Wang, Haikun Wang, Di Qu, Dimitri Lavillette, Hong Tang, Qiang Deng, Youhua Xie, Yao Cong, Zhong Huang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Here, the authors identify and characterize two mouse-derived monoclonal antibodies against SARS-CoV-2 spike protein that target different epitopes in RBD and block the interaction S/ACE2 and show that a formulated humanized version cocktail exhibits
Externí odkaz:
https://doaj.org/article/c3382a0b06624f9aa3dc99ff11e7fed0
Autor:
Tingting Li, Hongmin Cai, Hebang Yao, Bingjie Zhou, Ning Zhang, Martje Fentener van Vlissingen, Thijs Kuiken, Wenyu Han, Corine H. GeurtsvanKessel, Yuhuan Gong, Yapei Zhao, Quan Shen, Wenming Qin, Xiao-Xu Tian, Chao Peng, Yanling Lai, Yanxing Wang, Cedric A. J. Hutter, Shu-Ming Kuo, Juan Bao, Caixuan Liu, Yifan Wang, Audrey S. Richard, Hervé Raoul, Jiaming Lan, Markus A. Seeger, Yao Cong, Barry Rockx, Gary Wong, Yuhai Bi, Dimitri Lavillette, Dianfan Li
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/468b30b38fdf49a995f00338e612e44b
Autor:
Hebang Yao, Hongmin Cai, Tingting Li, Bingjie Zhou, Wenming Qin, Dimitri Lavillette, Dianfan Li
Publikováno v:
PLoS Pathogens, Vol 17, Iss 3, p e1009328 (2021)
A key step to the SARS-CoV-2 infection is the attachment of its Spike receptor-binding domain (S RBD) to the host receptor ACE2. Considerable research has been devoted to the development of neutralizing antibodies, including llama-derived single-chai
Externí odkaz:
https://doaj.org/article/a00ecf71171a45e8a8e1569298369b84