Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Dimitri A Svistunenko"'
Autor:
Ma Teresa Pellicer Martinez, Jason C Crack, Melissa YY Stewart, Justin M Bradley, Dimitri A Svistunenko, Andrew WB Johnston, Myles R Cheesman, Jonathan D Todd, Nick E Le Brun
Publikováno v:
eLife, Vol 8 (2019)
RirA is a global regulator of iron homeostasis in Rhizobium and related α-proteobacteria. In its [4Fe-4S] cluster-bound form it represses iron uptake by binding to IRO Box sequences upstream of RirA-regulated genes. Under low iron and/or aerobic con
Externí odkaz:
https://doaj.org/article/0b82d755b6fd45c294bb83a3bd369123
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6794 (2024)
Hell’s Gate globin-I (HGb-I) is a thermally stable globin from the aerobic methanotroph Methylacidiphilium infernorum. Here we report that HGb-I interacts with lipids stoichiometrically to induce structural changes in the heme pocket, changing the
Externí odkaz:
https://doaj.org/article/7d7d3e5dc99f475d81082ea4d9dbe60d
Autor:
Dimitri A. Svistunenko, Jonathan A. R. Worrall, Michael T. Wilson, Robin L. Owen, Marina Lučić, Michael A. Hough
Publikováno v:
Journal of Biological Inorganic Chemistry
Structure determination of proteins and enzymes by X-ray crystallography remains the most widely used approach to complement functional and mechanistic studies. Capturing the structures of intact redox states in metalloenzymes is critical for assigni
Autor:
Hannah R. Adams, Dimitri A. Svistunenko, Michael T. Wilson, Sotaro Fujii, Richard W. Strange, Zoe A. Hardy, Priscilla A. Vazquez, Tyler Dabritz, Gabriel J. Streblow, Colin R. Andrew, Michael A. Hough
Publikováno v:
Journal of Biological Chemistry. 299:104742
Autor:
Hiroshi Sugimoto, Takehiko Tosha, Ivo Tews, Robin L. Owen, A. Ebrahim, Michael A. Hough, Amanda K. Chaplin, Michael T. Wilson, Bradley Davy, Shigeki Owada, Dimitri A. Svistunenko, Florian S. N. Dworkowski, Marina Lučić, Jonathan A. R. Worrall, Danny Axford
Publikováno v:
Angewandte Chemie (International Ed. in English)
Obtaining structures of intact redox states of metal centers derived from zero dose X‐ray crystallography can advance our mechanistic understanding of metalloenzymes. In dye‐decolorising heme peroxidases (DyPs), controversy exists regarding the m
Autor:
Geoffrey R. Moore, Justin M. Bradley, Andrew M. Hemmings, Dimitri A. Svistunenko, Jacob Pullin, N.E. Le Brun
Publikováno v:
Dalton Transactions. 49:1545-1554
Ferritins are multimers comprised of 4 α-helical bundle monomers that co-assemble to form protein shells surrounding an approximately spherical internal cavity. The assembled multimers acquire Fe2+ from their surroundings by utilising channels that
Autor:
Michael T. Wilson, Marina Lučić, Amanda K. Chaplin, T. Moreno-Chicano, Florian S. N. Dworkowski, Michael A. Hough, Jonathan A. R. Worrall, Dimitri A. Svistunenko
Publikováno v:
Dalton Transactions. 49:1620-1636
Dye decolourising peroxidases (DyPs) are oxidative haem containing enzymes that can oxidise organic substrates by first reacting with hydrogen peroxide. Herein, we have focused on two DyP homologs, DtpAa and DtpA, from the soil-dwelling bacterium Str
Autor:
Andreea Manole, Dimitri A. Svistunenko
Publikováno v:
Journal of Biomedical Research
One of the difficulties in creating a blood substitute on the basis of human haemoglobin (Hb) is the toxic nature of Hb when it is outside the safe environment of the red blood cells. The plasma protein haptoglobin (Hp) takes care of the Hb physiolog
Autor:
Christopher Williams, Adrian J. Mulholland, Marc W. van der Kamp, H. Adrian Bunzel, Sarah A. Hindson, Dimitri A. Svistunenko, J. L. Ross Anderson, Bettina Frank, Christopher R. Pudney
Publikováno v:
Hindson, S A, Bunzel, H A, Frank, B, Svistunenko, D A, Williams, C, Van Der Kamp, M W, Mulholland, A J, Pudney, C R & Anderson, J L R 2021, ' Rigidifying a De Novo Enzyme Increases Activity and Induces a Negative Activation Heat Capacity ', ACS Catalysis, vol. 11, no. 18, pp. 11532-11541 . https://doi.org/10.1021/acscatal.1c01776
ACS Catalysis
ACS Catalysis
Conformational sampling profoundly impacts the overall activity and temperature dependence of enzymes. Peroxidases have emerged as versatile platforms for high-value biocatalysis owing to their broad palette of potential biotransformations. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed43cdd3f646d602781027cc8a9c317
https://research-information.bris.ac.uk/en/publications/ca6a7c7a-88b0-4ecd-a0e9-fac68b662546
https://research-information.bris.ac.uk/en/publications/ca6a7c7a-88b0-4ecd-a0e9-fac68b662546
Autor:
Dimitri A. Svistunenko
Publikováno v:
Journal of Biomedical Research
This mini-review gives a brief account of the emergence of the electron paramagnetic resonance (EPR) spectroscopy in the second half of the 20 th century and reports the continuous wave EPR spectroscopy studies on human and animal blood. The question