Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Dimitri, Shcherbakov"'
Autor:
Aline Cuénod, Jessica Agnetti, Helena M. B. Seth-Smith, Tim Roloff, Denise Wälchli, Dimitri Shcherbakov, Rashid Akbergenov, Sarah Tschudin-Sutter, Stefano Bassetti, Martin Siegemund, Christian H. Nickel, Jacob Moran-Gilad, Timothy G. Keys, Valentin Pflüger, Nicholas R. Thomson, Adrian Egli
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-17 (2023)
Abstract Background Urinary tract infections (UTIs) are among the most common bacterial infections worldwide, often caused by uropathogenic Escherichia coli. Multiple bacterial virulence factors or patient characteristics have been linked separately
Externí odkaz:
https://doaj.org/article/24bce8ec0d7249b99753281a7d7df2ce
Autor:
Philipp Koch, Steven Schmitt, Alexander Heynisch, Anja Gumpinger, Irene Wüthrich, Marina Gysin, Dimitri Shcherbakov, Sven N. Hobbie, Sven Panke, Martin Held
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-21 (2022)
Abstract Background Intracellularly active antimicrobial peptides are promising candidates for the development of antibiotics for human applications. However, drug development using peptides is challenging as, owing to their large size, an enormous s
Externí odkaz:
https://doaj.org/article/755df7666caf46a98e4895ca26a9e51a
Autor:
Adrián Cortés Sanchón, Harshitha Santhosh Kumar, Matilde Mantovani, Ivan Osinnii, José María Mateos, Andres Kaech, Dimitri Shcherbakov, Rashid Akbergenov, Erik C. Böttger
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Sanchón et al find that misfolded proteins formed in the ER can become associated with mitochondria, both in mammalian cells and in yeast, resulting in impaired mitochondrial function. They further discover that components of ERMES-mediated ER-mitoc
Externí odkaz:
https://doaj.org/article/bf08851619654161a435709327ef2900
Autor:
James Moore, Rashid Akbergenov, Martina Nigri, Patricia Isnard-Petit, Amandine Grimm, Petra Seebeck, Lisa Restelli, Stephan Frank, Anne Eckert, Kader Thiam, David P. Wolfer, Dimitri Shcherbakov, Erik C. Böttger
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
By introducing a ribosomal ambiguity mutation into mice, Moore et al. establish an in-vivo model to investigate how age-related diseases are related to decreasing accuracy in protein synthesis. Their findings potentially offer new insights into the p
Externí odkaz:
https://doaj.org/article/e6f25dccdabb450fa330934a966a5a73
Autor:
Erik C. Böttger, Harshitha Santhosh Kumar, Adrián Cortés Sanchón, José María Mateos, Ivan Osinnii, Matilde Mantovani, Dimitri Shcherbakov, Rashid Akbergenov, Andres Kaech
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Communications Biology
Communications Biology
Proteostasis is a challenge for cellular organisms, as all known protein synthesis machineries are error-prone. Here we show by cell fractionation and microscopy studies that misfolded proteins formed in the endoplasmic reticulum can become associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6747c5de9af675adc3d6acfd3b8fa390
https://doaj.org/article/bf08851619654161a435709327ef2900
https://doaj.org/article/bf08851619654161a435709327ef2900
Autor:
Vikram A. Sarpe, Klara Haldimann, Jonathan C. K. Quirke, Parasuraman Rajasekaran, David Crich, Erik C. Böttger, Andrea Vasella, Marina Gysin, Dimitri Shcherbakov, Ivan Osinnii, Qiao-Jun Fang, Su-Hua Sha, Amr Sonousi, Jochen Schacht, Sven N. Hobbie
Publikováno v:
J Am Chem Soc
Apramycin is a structurally unique member of the 2-deoxystreptamine class of aminoglycoside antibiotics characterized by a monosubstituted 2-deoxystreptamine ring that carries an unusual bicyclic eight-carbon dialdose moiety. Because of its unusual s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be01cde60231a3161dafd8f0b34f0fe0
https://doi.org/10.1021/jacs.9b11601
https://doi.org/10.1021/jacs.9b11601
Autor:
Philipp, Koch, Steven, Schmitt, Alexander, Heynisch, Anja, Gumpinger, Irene, Wüthrich, Marina, Gysin, Dimitri, Shcherbakov, Sven N, Hobbie, Sven, Panke, Martin, Held
Publikováno v:
BMC biology. 20(1)
Intracellularly active antimicrobial peptides are promising candidates for the development of antibiotics for human applications. However, drug development using peptides is challenging as, owing to their large size, an enormous sequence space is spa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3aca66c4177a385f404f27b517c5d94a
https://pubmed.ncbi.nlm.nih.gov/35578204
https://pubmed.ncbi.nlm.nih.gov/35578204
Autor:
David P. Wolfer, Dimitri Shcherbakov, Anne Eckert, Martina Nigri, Kader Thiam, James M. Moore, Rashid Akbergenov, Patricia Isnard-Petit, Stephan Frank, Amandine Grimm, Lisa Michelle Restelli, Petra Seebeck, Erik C. Böttger
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Communications Biology, 4 (1)
Communications Biology
Communications Biology, 4 (1)
Communications Biology
Random errors in protein synthesis are prevalent and ubiquitous, yet their effect on organismal health has remained enigmatic for over five decades. Here, we studied whether mice carrying the ribosomal ambiguity (ram) mutation Rps2-A226Y, recently sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::487cb8f0fe144899d28482206d6b3a04
https://doi.org/10.1038/s42003-021-02204-z
https://doi.org/10.1038/s42003-021-02204-z
Autor:
Richard E. Lee, Suresh Dharuman, Jiuyu Liu, Stephanie M. Reeve, Carl W Thompson, Robin B. Lee, John M Elmore, Erik C. Böttger, Laura A. Wilt, Dimitri Shcherbakov
Publikováno v:
Journal of Antibiotics, 74 (6)
The Journal of Antibiotics
The Journal of Antibiotics
Spectinomycin, an aminocyclitol antibiotic, is subject to inactivation by aminoglycoside modifying enzymes (AMEs) through adenylylation or phosphorylation of the 6-hydroxy group position. In this study, the effects of deoxygenation of the 2- and 6-hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab27dbc8b070686fe8d6a6b4c68320e
https://hdl.handle.net/20.500.11850/488447
https://hdl.handle.net/20.500.11850/488447
Autor:
Takahiko Matsushita, Girish C. Sati, Nuwan Kondasinghe, Michael G. Pirrone, Takayuki Kato, Prabuddha Waduge, Harshitha Santhosh Kumar, Adrian Cortes Sanchon, Malgorzata Dobosz-Bartoszek, Dimitri Shcherbakov, Mario Juhas, Sven N. Hobbie, Thomas Schrepfer, Christine S. Chow, Yury S. Polikanov, Jochen Schacht, Andrea Vasella, Erik C. Böttger, David Crich
Publikováno v:
Journal of the American Chemical Society. 141:5051-5061
Infectious diseases due to multidrug-resistant pathogens, particularly carbapenem-resistant Enterobacteriaceae (CREs), present a major and growing threat to human health and society, providing an urgent need for the development of improved potent ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c34ede7f66dda7d18fa0c31da76aba2c
https://doi.org/10.1021/jacs.9b01693
https://doi.org/10.1021/jacs.9b01693