Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Dimitar Serbezov"'
Autor:
Sena Karachanak-Yankova, Dimitar Serbezov, Marta Mihaylova, Dragomira Nikolova, Lubomir Balabanski, Vera Damyanova, Olga Antonova, Rada Staneva, Mihail Ganev, Victoria Spasova, Blaga Rukova, Desislava Nesheva, Slavica Josifovska, Mikaela Stancheva, Diana Belejanska, Mariya Petrova, Shima Mehrabian, Latchezar Traykov, Savina Hadjidekova, Draga Toncheva
Publikováno v:
Biotechnology & Biotechnological Equipment, Vol 37, Iss 1, Pp 74-78 (2023)
AbstractIn an effort to better understand the complex genetic background of Alzheimer’s disease (AD) we performed high-coverage whole-exome sequencing of a DNA pool assembled of 66 Bulgarian AD patients. We focused our analysis on genes demonstrate
Externí odkaz:
https://doaj.org/article/9f16b95efe9046c1b5858050d17509bf
Publikováno v:
Biotechnology & Biotechnological Equipment, Vol 37, Iss 1, Pp 42-48 (2023)
AbstractPublicly available genome-wide data, sequenced from 2730 ancient human samples were analyzed for genetic predisposition to malignancy. The temporal and spatial incidence of risk variants for cancer diseases in ancient genomes was recorded, al
Externí odkaz:
https://doaj.org/article/21e5be0b92d14c0d9ea4cc620da58400
Autor:
Lubomir Balabanski, Dimitar Serbezov, Maya Atanasoska, Sena Karachanak-Yankova, Savina Hadjidekova, Dragomira Nikolova, Olga Boyanova, Rada Staneva, Radoslava Vazharova, Marta Mihailova, Vera Damyanova, Desislava Nesheva, Diana Belejanska, Shima Mehrabian, Lachezar Traykov, Draga Toncheva
Publikováno v:
Biotechnology & Biotechnological Equipment, Vol 35, Iss 1, Pp 1256-1262 (2021)
Contemporary genetic methods have not yet solved the ‘missing heritability’ problem of complex diseases such as Alzheimer’s disease (AD). The impact of rare or less common variation on human complex diseases and traits remains to date barely in
Externí odkaz:
https://doaj.org/article/69eab2e91aa343ae9dd277605a11f652
Autor:
Marta Mihaylova, Dimitar Serbezov, Lubomir Balabanski, Sena Karachanak-Yankova, Dragomira Nikolova, Vera Damyanova, Savina Hadzhidekova, Draga Toncheva
Publikováno v:
Biotechnology & Biotechnological Equipment, Vol 34, Iss 1, Pp 690-697 (2020)
Overweight and obesity are serious and an ever-growing problem in modern society. It is a major risk factors for a number of chronic diseases, including type 2 diabetes, cardiovascular diseases and cancer. Obesity is a complex condition resulting fro
Externí odkaz:
https://doaj.org/article/77ee2932d79048f2ae77b1960d7d49c1
Publikováno v:
PLoS ONE, Vol 17, Iss 6, p e0269628 (2022)
Genetic disease burden in ancient communities has barely been evaluated despite an ever expanding body of ancient genomes becoming available. In this study, we inspect 2729 publicly available ancient genomes (100 BP-52000 BP) for the presence of path
Externí odkaz:
https://doaj.org/article/20ac22a600ab424b89f48b188fa24821
Autor:
Mihail Ganev, Lubomir Balabanski, Dimitar Serbezov, Sena Karachanak-Yankova, Radoslava Vazharova, Desislava Nesheva, Zora Hammoudeh, Dragomira Nikolova, Olga Antonova, Rada Staneva, Marta Mihaylova, Vera Damyanova, Savina Hadjidekova, Draga Toncheva
Publikováno v:
Biotechnology & Biotechnological Equipment, Vol 33, Iss 1, Pp 1757-1765 (2019)
Coronary heart disease (CHD) is a major cause of mortality and morbidity in Europe. CHD is usually caused by atherosclerosis. Despite extensive studies that have identified a large number of genetic variants, strong evidence of association with CHD a
Externí odkaz:
https://doaj.org/article/bb04476f30124e098a0c0d56ae2bf45c
Publikováno v:
Biotechnology & Biotechnological Equipment, Vol 32, Iss 6, Pp 1359-1366 (2018)
An ever larger portion of the world population survives into advanced old age, and that has been a steady trend for the last century. Despite some substantial advances in our understanding of the genomic basis of ageing in recent years, healthy agein
Externí odkaz:
https://doaj.org/article/8524e0af80ea40ca8e17de41f79ac162
Autor:
Lubomir Balabanski MSc, Dimitar Serbezov PhD, Dragomira Nikolova PhD, Olga Antonova PhD, Desislava Nesheva PhD, Zora Hammoudeh PhD, Radoslava Vazharova PhD, Sena Karachanak-Yankova PhD, Rada Staneva PhD, Marta Mihaylova PhD, Vera Damyanova PhD, Savina Hadjidekova PhD, Draga Toncheva PhD
Publikováno v:
Technology in Cancer Research & Treatment, Vol 19 (2020)
Objectives: The aim of the present study was to evaluate the clinical relevance of mutations in tumor suppressor genes using whole-exome sequencing data from centenarians and young healthy individuals. Methods: Two pools, one of centenarians and one
Externí odkaz:
https://doaj.org/article/0fe8fad5d789431cae223b2e68b77e63
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0233666 (2020)
Mitochondrial DNA variants associated with diseases are widely studied in contemporary populations, but their prevalence has not yet been investigated in ancient populations. The publicly available AmtDB database contains 1443 ancient mtDNA Eurasian
Externí odkaz:
https://doaj.org/article/bf2dbf030ae84faababf468e4180dbc2
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0122032 (2015)
Knowing the breeding system of a species is important in order to understand individual variation in reproductive success. Large variation in reproductive success and thus reproductive skew strongly impacts on the effective number of breeders and thu
Externí odkaz:
https://doaj.org/article/5e26af6037ba4501943ea36e6445034f