Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Dimitar B Nikolov"'
Autor:
Nayanendu Saha, Kai Xu, Zhongyu Zhu, Dorothea Robev, Teja Kalidindi, Yan Xu, Juha Himanen, Elisa de Stanchina, Naga Vara Kishore Pillarsetty, Dimiter S Dimitrov, Dimitar B Nikolov
Publikováno v:
Translational Oncology, Vol 15, Iss 1, Pp 101265- (2022)
ADAM17 is upregulated in many cancers and in turn activates signaling pathways, including EGFR/ErbB, as well as those underlying resistance to targeted anti-EGFR therapies. Due to its central role in oncogenic pathways and drug resistance mechanisms,
Externí odkaz:
https://doaj.org/article/0c1537a2f183403bbaf393d83c36b312
Autor:
Emilia O Mason, Yehuda Goldgur, Dorothea Robev, Andrew Freywald, Dimitar B Nikolov, Juha P Himanen
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0247335 (2021)
Eph receptors are the largest group amongst the receptor tyrosine kinases and are divided into two subgroups, A and B, based on ligand binding specificities and sequence conservation. Through ligand-induced and ligand-independent activities, Ephs pla
Externí odkaz:
https://doaj.org/article/33a68ea70da940d5bd84d6e4586d92aa
Autor:
Yixin Liu, Heidi Kaljunen, Ana Pavić, Tuulia Saarenpää, Juha P Himanen, Dimitar B Nikolov, Adrian Goldman
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0198291 (2018)
Eph/Ephrin signaling pathways are crucial in regulating a large variety of physiological processes during development, such as cell morphology, proliferation, migration and axonal guidance. EphrinA (efn-A) ligands, in particular, can be activated by
Externí odkaz:
https://doaj.org/article/5496aa2c19994eb2a8ce0b7c47119c5b
Autor:
Nayanendu Saha, Sang Gyu Lee, Eeva-Christine Brockmann, M. Jason de la Cruz, Yehuda Goldgur, Rachelle P. Mendoza, Elisa de Stanchina, Tanzy M. Love, Josh Marvald, Yan Xu, Kai Xu, Juha P. Himanen, Urpo Lamminmäki, Darren Veach, Dimitar B. Nikolov
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 180, Iss , Pp 117605- (2024)
ADAM17 sheds EGFR/erbB ligands and triggers oncogenic pathways that lead to the progression of solid tumors. We targeted the ADAM17 disintegrin and cysteine rich domain region (D+C) to generate a panel of single-chain antibody fragments (scFvs) that
Externí odkaz:
https://doaj.org/article/84264756775b4efcb4e2b8cf8b67bcb8
Autor:
Kai Xu, Yee-Peng Chan, Birgit Bradel-Tretheway, Zeynep Akyol-Ataman, Yongqun Zhu, Somnath Dutta, Lianying Yan, YanRu Feng, Lin-Fa Wang, Georgios Skiniotis, Benhur Lee, Z Hong Zhou, Christopher C Broder, Hector C Aguilar, Dimitar B Nikolov
Publikováno v:
PLoS Pathogens, Vol 11, Iss 12, p e1005322 (2015)
Nipah virus (NiV) is a paramyxovirus that infects host cells through the coordinated efforts of two envelope glycoproteins. The G glycoprotein attaches to cell receptors, triggering the fusion (F) glycoprotein to execute membrane fusion. Here we repo
Externí odkaz:
https://doaj.org/article/d7d53e34d8c04943b73c50bfbe07fb34
Autor:
Kai Xu, Barry Rockx, Yihu Xie, Blair L DeBuysscher, Deborah L Fusco, Zhongyu Zhu, Yee-Peng Chan, Yan Xu, Truong Luu, Regina Z Cer, Heinz Feldmann, Vishwesh Mokashi, Dimiter S Dimitrov, Kimberly A Bishop-Lilly, Christopher C Broder, Dimitar B Nikolov
Publikováno v:
PLoS Pathogens, Vol 9, Iss 10, p e1003684 (2013)
The henipaviruses, represented by Hendra (HeV) and Nipah (NiV) viruses are highly pathogenic zoonotic paramyxoviruses with uniquely broad host tropisms responsible for repeated outbreaks in Australia, Southeast Asia, India and Bangladesh. The high mo
Externí odkaz:
https://doaj.org/article/a38650bbd6514da499ae2611edeed0d5
Autor:
Kai Xu, Yee-Peng Chan, Kanagalaghatta R Rajashankar, Dimple Khetawat, Lianying Yan, Momchil V Kolev, Christopher C Broder, Dimitar B Nikolov
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48742 (2012)
Hendra virus and Nipah virus, comprising the genus Henipavirus, are recently emerged, highly pathogenic and often lethal zoonotic agents against which there are no approved therapeutics. Two surface glycoproteins, the attachment (G) and fusion (F), m
Externí odkaz:
https://doaj.org/article/9cd9da1efa7d4d73b83bdf78de192357
Autor:
Rachelle P. Mendoza, Amir Momeni, Nayanendu Saha, Juwairiya Arshi, Elmer C. Gabutan, Nichole Alejandro, Alejandro Zuretti, Prem K. Premsrirut, Dimitar B. Nikolov
Publikováno v:
Microorganisms, Vol 11, Iss 12, p 2940 (2023)
The viral agent SARS-CoV-2 clearly affects several organ systems, including the cardiovascular system. Angiopoietins are involved in vascular integrity and angiogenesis. Angiopoietin-1 (Ang1) promotes vessel stabilization, while angiopoietin-2 (Ang2)
Externí odkaz:
https://doaj.org/article/c805ffd9a79c4f5e939fd06e43625d10
Autor:
Amr El Zawily, Frederick S. Vizeacoumar, Renuka Dahiya, Sara L. Banerjee, Kalpana K. Bhanumathy, Hussain Elhasasna, Glinton Hanover, Jessica C. Sharpe, Malkon G. Sanchez, Paul Greidanus, R. Greg Stacey, Kyung-Mee Moon, Ilya Alexandrov, Juha P. Himanen, Dimitar B. Nikolov, Humphrey Fonge, Aaron P. White, Leonard J. Foster, Bingcheng Wang, Behzad M. Toosi, Nicolas Bisson, Tajib A. Mirzabekov, Franco J. Vizeacoumar, Andrew Freywald
Publikováno v:
Clinical Cancer Research. :OF1-OF16
Purpose: Accumulating analyses of pro-oncogenic molecular mechanisms triggered a rapid development of targeted cancer therapies. Although many of these treatments produce impressive initial responses, eventual resistance onset is practically unavoida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9093b523847f1e2653795293982fb01d
https://doi.org/10.1158/1078-0432.ccr-22-2535
https://doi.org/10.1158/1078-0432.ccr-22-2535
Autor:
Andrew Freywald, Franco J. Vizeacoumar, Tajib A. Mirzabekov, Nicolas Bisson, Behzad M. Toosi, Bingcheng Wang, Leonard J. Foster, Aaron P. White, Humphrey Fonge, Dimitar B. Nikolov, Juha P. Himanen, Ilya Alexandrov, Kyung-Mee Moon, R. Greg Stacey, Paul Greidanus, Malkon G. Sanchez, Jessica C. Sharpe, Glinton Hanover, Hussain Elhasasna, Kalpana K. Bhanumathy, Sara L. Banerjee, Renuka Dahiya, Frederick S. Vizeacoumar, Amr El Zawily
Fig. S1. The amino acid sequence of EPHA2 extracellular portion composed of ligand bindingdomain followed by sushi-like domain and two sequential fibronectin-like domains is highlyconserved among mammals.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a59b764f3c21b1ae1bdb483d0ebc7db
https://doi.org/10.1158/1078-0432.22348792
https://doi.org/10.1158/1078-0432.22348792
