Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Dima N. Gharaibeh"'
Autor:
Ikenna G Madu, Megan Files, Dima N Gharaibeh, Amy L Moore, Kie-Hoon Jung, Brian B Gowen, Dongcheng Dai, Kevin F Jones, Shanthakumar R Tyavanagimatt, James R Burgeson, Marcus J Korth, Kristin M Bedard, Shawn P Iadonato, Sean M Amberg
Publikováno v:
PLoS Pathogens, Vol 14, Iss 12, p e1007439 (2018)
Arenaviruses are a significant cause of hemorrhagic fever, an often-fatal disease for which there is no approved antiviral therapy. Lassa fever in particular generates high morbidity and mortality in West Africa, where the disease is endemic, and a r
Externí odkaz:
https://doaj.org/article/158943d5f7714c32981e426acdf08c68
Autor:
Veronica Soloveva, Dima N. Gharaibeh, Adam Schafer, Norton P. Peet, Cary Retterer, Tara Kenny, Rouzbeh Zamani, Lijun Rong, Han Cheng, Sina Bavari
Publikováno v:
Antiviral Research
Filoviruses, consisting of Ebola virus, Marburg virus and Cuevavirus, cause severe hemorrhagic fevers in humans with high mortality rates up to 90%. Currently, there is no approved vaccine or therapy available for the prevention and treatment of filo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6f3d4e9e8ec9dfb90dbf235f2b665d8
https://doi.org/10.1016/j.antiviral.2017.06.015
https://doi.org/10.1016/j.antiviral.2017.06.015
Autor:
James R. Burgeson, Kristin Bedard, Sean M. Amberg, Megan Files, Kevin F. Jones, Shawn P. Iadonato, Marcus J. Korth, Dima N. Gharaibeh, Dongcheng Dai, Amy L. Moore, Ikenna G. Madu, Shanthakumar R. Tyavanagimatt, Kieh-Hoon Jung, Brian B. Gowen
Publikováno v:
PLoS Pathogens, Vol 14, Iss 12, p e1007439 (2018)
PLoS Pathogens
Animal, Dairy, and Veterinary Science Faculty Publications
PLoS Pathogens
Animal, Dairy, and Veterinary Science Faculty Publications
Arenaviruses are a significant cause of hemorrhagic fever, an often-fatal disease for which there is no approved antiviral therapy. Lassa fever in particular generates high morbidity and mortality in West Africa, where the disease is endemic, and a r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acfd2114900d28a5cf2d40cc650d80a8
https://doaj.org/article/158943d5f7714c32981e426acdf08c68
https://doaj.org/article/158943d5f7714c32981e426acdf08c68
Autor:
Stuart T. Nichol, Brett P. Eaton, Nate Larson, Ginger Donnelly, Mike Flint, Robert Jordan, Douglas L. Mayers, Michel Perron, Yeojin Park, Dustin Siegel, Lydia Wolfe, Veronica Soloveva, Edward Doerffler, William A. Lee, Donald K. Nichols, Dima N. Gharaibeh, Elizabeth C. Grimes, Laura Gomba, Darius Babusis, Travis K. Warren, Kwon Soo Chun, Tomas Cihlar, Queenie Wang, Adrian S. Ray, Kirsten M. Stray, Bruce Ross, Elyse R. Nagle, Kelly S. Stuthman, Lisa S. Welch, Rachel Fearns, Jonathan E. Nuss, Willard Lew, Jeffrey R. Kugelman, Molly R. Braun, Roy Bannister, Richard L. Mackman, Pamela Wong, Christina F. Spiropoulou, Joy Y. Feng, Hui Hon Chung, Ona Barauskas, Sean Neville, Jay Wells, Robert G. Strickley, Catherine L. Wilhelmsen, S. Swaminathan, Iva Trancheva, Nicole L. Garza, Cary Retterer, Michael K. Lo, Sean A. Van Tongeren, Gustavo Palacios, Laura K. McMullan, Amy C. Shurtleff, Lijun Zhang, Michael O. Clarke, Yili Xu, Sina Bavari, Tara Kenny, Ernest Carra, Rouzbeh Zamani, Shan Shan Chen
Publikováno v:
Nature
The most recent Ebola virus outbreak in West Africa, which was unprecedented in the number of cases and fatalities, geographic distribution, and number of nations affected, highlights the need for safe, effective, and readily available antiviral agen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::766327a9b5d4cc0d2298b57ff34377c6
http://europepmc.org/articles/PMC5551389
http://europepmc.org/articles/PMC5551389
Autor:
Života Selaković, Rekha G. Panchal, Jay Wells, Bogdan A. Šolaja, Veronica Soloveva, Dima N. Gharaibeh, Sandra Šegan
Publikováno v:
ACS INFECTIOUS DISEASES
Herein we report on a diazachrysene class of small molecules that exhibit potent antiviral activity against the Ebola (EBOV) virus. The antiviral compounds are easily synthesized, and the most active compounds have excellent in vitro activity (0.34-0
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee7142fcdd46eaf4d1982bd43d7c5cb0
https://doi.org/10.1021/acsinfecdis.5b00028
https://doi.org/10.1021/acsinfecdis.5b00028
Publikováno v:
Methods in Molecular Biology ISBN: 9781493969807
The majority of viruses causing hemorrhagic fever in humans are Risk Group 3 or 4 pathogens and, therefore, can only be handled in biosafety level 3 or 4 (BSL-3/4) containment laboratories. The restricted number of such laboratories, the substantial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ea69ae2338cb643e8f46f687e5043ff
https://doi.org/10.1007/978-1-4939-6981-4_29
https://doi.org/10.1007/978-1-4939-6981-4_29
Autor:
Yongjun Jiang, Hong Shang, Veronica Soloveva, Binhua Ling, Dima N. Gharaibeh, Chul Park, Deemah Dabbagh, John Naughton, Jacque Fontenot, Mathieu Bibian, Xuehua Xu, Ramin M. Hakami, Yan Yin, John A. T. Young, Sijia He, Cary Retterer, HaJeung Park, Margaret L. Pitt, Yuntao Wu, Mark Spear, Ke Zheng, Sina Bavari, Yangbo Feng, Kylene Kehn-Hall, Jia Guo, Rouzbeh Zamani, Fei Yi
Publikováno v:
Journal of Virology
A dynamic actin cytoskeleton is necessary for viral entry, intracellular migration, and virion release. For HIV-1 infection, during entry, the virus triggers early actin activity by hijacking chemokine coreceptor signaling, which activates a host dep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e898b57f02a46d761e6b3ce080ea362
https://doi.org/10.1128/jvi.02418-16
https://doi.org/10.1128/jvi.02418-16
Discovery and optimization of potent broad-spectrum arenavirus inhibitors derived from benzimidazole
Autor:
Natasha R. Cerruti, James R. Burgeson, Sean M. Amberg, Ryan A. Larson, Dongcheng Dai, Dima N. Gharaibeh, Dennis E. Hruby, Amy L. Moore, Tove' C. Bolken
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:744-749
A chemically diverse library of about 400,000 small molecules was screened for antiviral activity against lentiviral pseudotypes with the Lassa virus envelope glycoprotein (LASV GP) gene incorporated. High-throughput screening resulted in discovery o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1017e30fc2771db2e9602a7988ca5a9
https://doi.org/10.1016/j.bmcl.2012.11.095
https://doi.org/10.1016/j.bmcl.2012.11.095
Autor:
James R. Burgeson, Amy L. Moore, Dima N. Gharaibeh, Dongcheng Dai, Natasha R. Cerruti, Ryan A. Larson, Dennis E. Hruby, Sean M. Amberg
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:750-756
A series of potent arenavirus inhibitors sharing a benzimidazole core were previously reported by our group. SAR studies were expanded beyond the previous analysis, which involved the attached phenyl rings and methylamino linker portion, to include m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba2c2a1ff6ad85382b226d185033224
https://doi.org/10.1016/j.bmcl.2012.11.093
https://doi.org/10.1016/j.bmcl.2012.11.093
Autor:
Jeffrey H. Elliott, Rouzbeh Zamani, Farooq Nasar, Sina Bavari, Sharon H. Tran, Mikhail Martchenko, Leeor Zilbermintz, William Leonardi, Xiaoli Chi, Anastasia Levitin, Veronica Soloveva, Dima N. Gharaibeh, Michael C. Bassik, Robert Manasherob, Stanley N. Cohen, Josue Zozaya, Tara Kenny, Luisa W. Cheng, Andrew D. Haddow, Kseniya Polukhina, Amy Li
Publikováno v:
Scientific Reports
Diverse pathogenic agents often utilize overlapping host networks and hub proteins within these networks represent attractive targets for broad-spectrum drugs. Using bacterial toxins, we describe a new approach for discovering broad-spectrum therapie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b844fd946b94bb3faa228b6b190aa7
https://doi.org/10.1038/srep34475
https://doi.org/10.1038/srep34475