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pro vyhledávání: '"Dilshad Blackinton"'
Autor:
Shashi Mehta, Dilshad Blackinton, Imran Omar, Nicola Kouttab, Dorkina Myrick, Jim Klostergaard, Harold Wanebo
Publikováno v:
Cancer Chemotherapy and Pharmacology. 46:85-92
Purpose: Paclitaxel, a chemotherapeutic agent used in the treatment of recalcitrant ovarian and breast as well as other neoplasms, is being investigated for the treatment of squamous cell carcinoma of the head and neck. Our previous studies have demo
Publikováno v:
The American Journal of Surgery. 162:384-387
The majority of patients with head and neck cancer present with advanced disease (stage III and IV), for which current chemotherapeutic regimens offer dismal results. Although known to have defects in their cell-mediated immunity, their poor performa
Autor:
Dilshad Blackinton, Shashi Mehta, Harold J. Wanebo, Nicola Kouttab, Jim Klostergaard, Dorkina Myrick, Abby Maizel
Publikováno v:
Leukemia research. 23(6)
We hypothesized that the lipid second messenger, ceramide, and microtubule-directed chemotherapeutic agents might engage converging pathways in inducing apoptosis. Our studies demonstrated that simultaneous treatment of Jurkat cells with paclitaxel a
Publikováno v:
Annals of surgical oncology. 4(2)
Depressed cell-mediated immunity is a frequent event in patients with head and neck cancer and is characterized by impairment of T cell-proliferative responses and natural killer cell and lymphokine-activated killer cell activity. This immunosuppress
Publikováno v:
American journal of surgery. 166(4)
The immune system of patients with head and neck cancer is frequently depressed. Serum inhibitory factors and immune cell dysfunction are known contributors to this depression, but their relative roles are unclear. We have examined these factors to d