EARLY OR LATE IL-10 BLOCKADE ENHANCES TH1 AND TH17 EFFECTOR RESPONSES AND PROMOTES FUNGAL CLEARANCE IN MICE WITH CRYPTOCOCCAL LUNG INFECTION1

Autor: Murdock, Benjamin J, Teitz-Tennenbaum, Seagal, Chen, Gwo-Hsiao, Dils, Anthony J., Malachowski, Antoni N., Curtis, Jeffrey L., Olszewski, Michal A., Osterholzer, John J.

The potent immunoregulatory properties of Interleukin-10 (IL-10) can counteract protective immune responses and thereby promote persistent infections as evidenced by prior studies of cryptococcal lung infection in IL-10 deficient mice. To further inv

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https://europepmc.org/articles/PMC4193595/

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Local GM-CSF-Dependent Differentiation and Activation of Pulmonary Dendritic Cells and Macrophages Protect against Progressive Cryptococcal Lung Infection in Mice.

Autor: Chen GH; Research Service, Ann Arbor VA Health System, Department of Veterans Affairs Health System, Ann Arbor, MI 48105; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109;, Teitz-Tennenbaum S; Research Service, Ann Arbor VA Health System, Department of Veterans Affairs Health System, Ann Arbor, MI 48105; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109;, Neal LM; Research Service, Ann Arbor VA Health System, Department of Veterans Affairs Health System, Ann Arbor, MI 48105; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109;, Murdock BJ; Research Service, Ann Arbor VA Health System, Department of Veterans Affairs Health System, Ann Arbor, MI 48105; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109;, Malachowski AN; Research Service, Ann Arbor VA Health System, Department of Veterans Affairs Health System, Ann Arbor, MI 48105; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109;, Dils AJ; Research Service, Ann Arbor VA Health System, Department of Veterans Affairs Health System, Ann Arbor, MI 48105; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109;, Olszewski MA; Research Service, Ann Arbor VA Health System, Department of Veterans Affairs Health System, Ann Arbor, MI 48105; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109; Graduate Program in Immunology, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109; and., Osterholzer JJ; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109; Graduate Program in Immunology, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109; and Pulmonary Section, Medical Service, Ann Arbor VA Health System, Department of Veterans Affairs Health System, Ann Arbor, MI 48105 oster@umich.edu.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2016 Feb 15; Vol. 196 (4), pp. 1810-21. Date of Electronic Publication: 2016 Jan 11.