Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Dilraj Lama"'
Autor:
Dilraj Lama, Thibault Vosselman, Cagla Sahin, Judit Liaño-Pons, Carmine P. Cerrato, Lennart Nilsson, Kaare Teilum, David P. Lane, Michael Landreh, Marie Arsenian Henriksson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The c-MYC oncogene is activated in over 70% of all human cancers. The intrinsic disorder of the c-MYC transcription factor facilitates molecular interactions that regulate numerous biological pathways, but severely limits efforts to target i
Externí odkaz:
https://doaj.org/article/dc5827f1d64e4af7bed720320a85059d
Autor:
Yuri Frosi, Yen-Chu Lin, Jiang Shimin, Siti Radhiah Ramlan, Kelly Hew, Alf Henrik Engman, Anil Pillai, Kit Yeung, Yue Xiang Cheng, Tobias Cornvik, Par Nordlund, Megan Goh, Dilraj Lama, Zachary P. Gates, Chandra S. Verma, Dawn Thean, David P. Lane, Ignacio Asial, Christopher J. Brown
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Approaches have been devised to increase the discovery rate of intrabodies but often these yield results that aren’t functional in cells. Here the authors engineer and optimise an autonomous and disulphide-free human VH domain for intracellular exp
Externí odkaz:
https://doaj.org/article/e93e759ee68a4352930b901a4ebc4c2b
Autor:
Wen Jing Sim, Prasanna Vasudevan Iyengar, Dilraj Lama, Sarah Kit Leng Lui, Hsien Chun Ng, Lior Haviv-Shapira, Eytan Domany, Dennis Kappei, Tuan Zea Tan, Azad Saei, Patrick William Jaynes, Chandra Shekhar Verma, Alan Prem Kumar, Mathieu Rouanne, Hong Koo Ha, Camelia Radulescu, Peter ten Dijke, Pieter Johan Adam Eichhorn, Jean Paul Thiery
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
HGF/c-MET upregulation is frequent in bladder cancer. Here, the authors show that HGF induces EMT and invasion by stabilising TGFβ receptor through inhibition of the SMURF2 ligase, and the combined blockade of MAPK and TGFβ pathways suppresses HGF-
Externí odkaz:
https://doaj.org/article/c563b6db7c52440f8cb6c74048d684b4
Autor:
Wen Jing Sim, Prasanna Vasudevan Iyengar, Dilraj Lama, Sarah Kit Leng Lui, Hsien Chun Ng, Lior Haviv-Shapira, Eytan Domany, Dennis Kappei, Tuan Zea Tan, Azad Saei, Patrick William Jaynes, Chandra Shekhar Verma, Alan Prem Kumar, Mathieu Rouanne, Hong Koo Ha, Camelia Radulescu, Peter ten Dijke, Pieter Johan Adam Eichhorn, Jean Paul Thiery
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/f7e419a41a3542c79c6ef6b730e52968
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e54397 (2013)
Bcl-XL is a member of Bcl-2 family of proteins involved in the regulation of intrinsic pathway of apoptosis. Its overexpression in many human cancers makes it an important target for anti-cancer drugs. Bcl-XL interacts with the BH3 domain of several
Externí odkaz:
https://doaj.org/article/23b92eeea92840889150f3ac66721171
Autor:
Axel Leppert, Gefei Chen, Dilraj Lama, Cagla Sahin, Vaida Railaite, Olga Shilkova, Tina Arndt, Erik G. Marklund, David P. Lane, Anna Rising, Michael Landreh
Publikováno v:
Leppert, A, Chen, G, Lama, D, Sahin, C, Railaite, V, Shilkova, O, Arndt, T, Marklund, E G, Lane, D P, Rising, A & Landreh, M 2023, ' Liquid-Liquid Phase Separation Primes Spider Silk Proteins for Fiber Formation via a Conditional Sticker Domain ', Nano Letters, vol. 23, no. 12 . https://doi.org/10.1021/acs.nanolett.3c00773
Many protein condensates can convert to fibrillar aggregates, but the underlying mechanisms are unclear. Liquid-liquid phase separation (LLPS) of spider silk proteins, spidroins, suggests a regulatory switch between both states. Here, we combine micr
Autor:
Saikiran K. Sedimbi, David P. Lane, Marika Nestor, Fredrik Wermeling, Mikael C. I. Karlsson, Eduardo J. Villablanca, Nicolas Fritz, Omayma Al-Radi, Warren W. Kretzschmar, Cecilia Bosdotter, Francisca Castillo, Dilraj Lama, Danai Lianoudaki, Silke Eisinger, Long Jiang, Jessica Hacheney, Linnéa Påvénius, Pavitra Kannan, Diana Spiegelberg, Katrine Ingelshed
Navtemadlin treatment does not lead to bone marrow suppression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a90dbf8b28abaaa778aed804267ac7
https://doi.org/10.1158/2767-9764.22545461
https://doi.org/10.1158/2767-9764.22545461
Autor:
Saikiran K. Sedimbi, David P. Lane, Marika Nestor, Fredrik Wermeling, Mikael C. I. Karlsson, Eduardo J. Villablanca, Nicolas Fritz, Omayma Al-Radi, Warren W. Kretzschmar, Cecilia Bosdotter, Francisca Castillo, Dilraj Lama, Danai Lianoudaki, Silke Eisinger, Long Jiang, Jessica Hacheney, Linnéa Påvénius, Pavitra Kannan, Diana Spiegelberg, Katrine Ingelshed
The tumor suppressor protein p53 is mutated in close to 50% of human tumors and is dysregulated in many others, for instance by silencing or loss of p14ARF. Under steady-state conditions, the two E3 ligases MDM2/MDM4 interact with and inhibit the tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::000188325df54f8c15797ee060e15664
https://doi.org/10.1158/2767-9764.c.6550949.v1
https://doi.org/10.1158/2767-9764.c.6550949.v1
Autor:
Saikiran K. Sedimbi, David P. Lane, Marika Nestor, Fredrik Wermeling, Mikael C. I. Karlsson, Eduardo J. Villablanca, Nicolas Fritz, Omayma Al-Radi, Warren W. Kretzschmar, Cecilia Bosdotter, Francisca Castillo, Dilraj Lama, Danai Lianoudaki, Silke Eisinger, Long Jiang, Jessica Hacheney, Linnéa Påvénius, Pavitra Kannan, Diana Spiegelberg, Katrine Ingelshed
Proteomics data.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c11d2af10f59413e8f1e955c8d5ca61d
https://doi.org/10.1158/2767-9764.22545455.v1
https://doi.org/10.1158/2767-9764.22545455.v1
Autor:
Saikiran K. Sedimbi, David P. Lane, Marika Nestor, Fredrik Wermeling, Mikael C. I. Karlsson, Eduardo J. Villablanca, Nicolas Fritz, Omayma Al-Radi, Warren W. Kretzschmar, Cecilia Bosdotter, Francisca Castillo, Dilraj Lama, Danai Lianoudaki, Silke Eisinger, Long Jiang, Jessica Hacheney, Linnéa Påvénius, Pavitra Kannan, Diana Spiegelberg, Katrine Ingelshed
Complete list of proteins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::029707c1d6bcf34612f00c36c04b3e48
https://doi.org/10.1158/2767-9764.22545458.v1
https://doi.org/10.1158/2767-9764.22545458.v1