Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Dillon Voss"'
Publikováno v:
bioRxiv
Aberrant alternative splicing is emerging as a cancer hallmark and a potential therapeutic target. It is the result of dysregulated splicing factors or genetic alterations in splicing-regulatorycis-elements. Targeting individual altered splicing even
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94dd14c007639df8f3370d6de82dda68
https://europepmc.org/articles/PMC10103938/
https://europepmc.org/articles/PMC10103938/
Autor:
Kazufumi Ohshiro, Krishanu Bhowmick, Xiaochun Yang, Addison Klebanov, Sahara John, Dillon Voss, Adrian Krainer, Lopa Mishra
Publikováno v:
Cancer Research. 83:4854-4854
Background: Non-alcoholic steatohepatitis (NASH) and cirrhosis are major risk factors for hepatocellular carcinoma (HCC), which affects men 2-4 times more than women. In tumors Pyruvate kinase M2 (PKM2), induces aerobic glycolysis (Warburg effect) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a1fd16e976661dea803298bbbf857c6
https://doi.org/10.1158/1538-7445.am2023-4854
https://doi.org/10.1158/1538-7445.am2023-4854
Autor:
Lucia Yang, Young Jin Kim, Nicole Sivetz, Jessica Layne, Adrian Krainer, Qian Zhang, Dillon Voss
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which can lead to respiratory failure. To date, there is no treatment for CF caused by the CFTR-W1282X mutation located o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60183974356954a7970a6dd3a623dd7f
https://pubmed.ncbi.nlm.nih.gov/35017301
https://pubmed.ncbi.nlm.nih.gov/35017301
Autor:
Qian Zhang, Young Jin Kim, Jessica Layne, Dillon Voss, Adrian R. Krainer, Nicole Sivetz, Lucia Yang
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause cystic fibrosis (CF), and theCFTR-W1282Xnonsense mutation causes a severe form of CF. Although Trikafta and other CFTR-modulation therapies benefit most CF patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd02f4daf4b5a5e62679e822755b5a94
https://doi.org/10.1101/2021.08.11.455936
https://doi.org/10.1101/2021.08.11.455936
Publikováno v:
Neuro Oncol
Muscleblind-like-proteins (MBNL) belong to a family of tissue-specific RNA metabolism-regulators that control pre-messenger RNA-splicing (AS). Inactivation of MBNL causes an adult-to-fetal AS transition, resulting in the development of myotonic dystr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b80d5ea5010277c27b9961daad71ffb6
https://doi.org/10.1093/neuonc/noaa215.936
https://doi.org/10.1093/neuonc/noaa215.936