Výsledky vyhledávání - "Dillon Strepay"

Akademický článek

Transgenic Tg(Kcnj10-ZsGreen) fluorescent reporter mice allow visualization of intermediate cells in the stria vascularis

Autor: Dillon Strepay, Rafal T. Olszewski, Sydney Nixon, Soumya Korrapati, Samuel Adadey, Andrew J. Griffith, Yijun Su, Jiamin Liu, Harshad Vishwasrao, Shoujun Gu, Thomas Saunders, Isabelle Roux, Michael Hoa

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)

Abstract The stria vascularis (SV) is a stratified epithelium in the lateral wall of the mammalian cochlea, responsible for both endolymphatic ion homeostasis and generation of the endocochlear potential (EP) critical for normal hearing. The SV has t

Externí odkaz: https://doaj.org/article/bb8c7c0b6df341d3a917073f881c322a

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Dissection of Adult Mouse Stria Vascularis for Single-Nucleus Sequencing or Immunostaining

Autor: Dillon Strepay, Rafal Olszewski, Ian Taukulis, J. Dixon Johns, Shoujun Gu, Michael Hoa

Publikováno v: Journal of Visualized Experiments.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9329f147b9f7dd562ea2d2e51a31c608
https://doi.org/10.3791/65254

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Identification of harmine and β-carboline analogs from a high-throughput screen of an approved drug collection; profiling as differential inhibitors of DYRK1A and monoamine oxidase A and for in vitro and in vivo anti-cancer studies

Autor: Christopher P. Laudeman, David B. Darr, Rhashad Thomas, Hassan Shehata, Kevin P. Williams, Helen Oladapo, Rob U. Onyenwoke, Jose R. Roques, Michael Tarpley, Lhoucine Chdid, Dillon Strepay, Thomas B. Caligan

Publikováno v: Eur J Pharm Sci

DYRK1A (dual-specificity tyrosine phosphorylation-regulated kinase 1a) is highly expressed in glioma, an aggressive brain tumor, and has been proposed as a therapeutic target for cancer. In the current study, we have used an optimized and validated t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c942fb21fea4acf32e7ecc5d0a28955
https://pubmed.ncbi.nlm.nih.gov/33781856

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Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells

Autor: David B. Darr, Jodie M. Fleming, Lhoucine Chdid, Shalonda M. Ingram, Dillon Strepay, Helen Oladapo, Gayathri R. Devi, Kezia A. Addo, Michael Tarpley, Jose R. Roques, Ben K. Ehe, Scott J. Sauer, Michael Trinkler, Kevin P. Williams

Publikováno v: Cancer Letters. 411:136-149

Activation of the Hedgehog (Hh) pathway effector GLI1 is linked to tumorigenesis and invasiveness in a number of cancers, with targeting of GLI1 by small molecule antagonists shown to be effective. We profiled a collection of GLI antagonists possessi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b77375568cff26c83daedf024fa1e62
https://doi.org/10.1016/j.canlet.2017.09.033

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Abstract A138: Profiling of harmine and select analogs as differential inhibitors of DYRK1A and monoamine oxidase A: Exploring the potential for anti-cancer efficacy and minimizing off-target activity

Autor: David B. Darr, Rob U. Onyenwoke, Hassan Shehata, Michael Tarpley, Dillon Strepay, Helen Oladapo, Kevin P. Williams, Jose R. Roques

Publikováno v: Molecular Cancer Therapeutics. 18:A138-A138

DYRK1A (dual-specificity tyrosine phosphorylation-regulated kinase 1a) phosphorylates a number of substrates on serine/threonine residues, including tau, amyloid precursor protein, DREAM, and GLI1. DYRK1A is expressed in both the adult and fetal brai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c5eaaed9f6abb090b35bfcfa944aac1d
https://doi.org/10.1158/1535-7163.targ-19-a138

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