Výsledky vyhledávání - "Dillon C. Gavlock"

Akademický článek

Comparison of wild-type and high-risk PNPLA3 variants in a human biomimetic liver microphysiology system for metabolic dysfunction-associated steatotic liver disease precision therapy

Autor: Mengying Xia, Mahboubeh Varmazyad, Iris Pla-Palacín, Dillon C. Gavlock, Richard DeBiasio, Gregory LaRocca, Celeste Reese, Rodrigo M. Florentino, Lanuza A. P. Faccioli, Jacquelyn A. Brown, Lawrence A. Vernetti, Mark Schurdak, Andrew M. Stern, Albert Gough, Jaideep Behari, Alejandro Soto-Gutierrez, D. Lansing Taylor, Mark T. Miedel

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 12 (2024)

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a worldwide health epidemic with a global occurrence of approximately 30%. The pathogenesis of MASLD is a complex, multisystem disorder driven by multiple factors, including genetics

Externí odkaz: https://doaj.org/article/ee7744aae33d4960a923808275c298d0

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Quantifying the progression of non-alcoholic fatty liver disease in human biomimetic liver microphysiology systems with fluorescent protein biosensors

Autor: Anupma Jha, Tong Ying Shun, Dillon C. Gavlock, Vijay Yechoor, Vineet Mahajan, Daniel E. Lefever, Xiang Li, Alejandro Soto-Gutierrez, Lawrence Vernetti, Jaideep Behari, D. Lansing Taylor, Albert Gough, Erin E. Kershaw, Celeste E. Reese, Richard DeBiasio, Manush Saydmohammed, Mark T. Miedel, Andrew M. Stern

Publikováno v: Exp Biol Med (Maywood)

Metabolic syndrome is a complex disease that involves multiple organ systems including a critical role for the liver. Non-alcoholic fatty liver disease (NAFLD) is a key component of the metabolic syndrome and fatty liver is linked to a range of metab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cbce253b16728f7163251422a3bba7d
https://doi.org/10.1177/15353702211009228

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Modeling the Effect of the Metastatic Microenvironment on Phenotypes Conferred by Estrogen Receptor Mutations Using a Human Liver Microphysiological System

Autor: Mark T. Miedel, Andrew M. Stern, D. Lansing Taylor, Dillon C. Gavlock, Albert Gough, Shanhang Jia

Publikováno v: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)

Reciprocal coevolution of tumors and their microenvironments underlies disease progression, yet intrinsic limitations of patient-derived xenografts and simpler cell-based models present challenges towards a deeper understanding of these intercellular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a53ae4b73d61f15d8dac17cc930a5430
http://europepmc.org/articles/PMC6554298

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