mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant.

Autor: Nanishi E; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., McGrath ME; Department of Microbiology and Immunology, The Center for Pathogen Research, University of Maryland School of Medicine, Baltimore, MD, USA., O'Meara TR; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA., Barman S; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Yu J; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Wan H; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Dillen CA; Department of Microbiology and Immunology, The Center for Pathogen Research, University of Maryland School of Medicine, Baltimore, MD, USA., Menon M; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA., Seo HS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Song K; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Xu AZ; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Sebastian L; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Brook B; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Bosco AN; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA., Borriello F; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.; Division of Immunology, Boston Children's Hospital, Boston, MA, USA.; Generate Biomedicines, Cambridge, MA, USA., Ernst RK; Department of Microbial Pathogenesis, University of Maryland School of Dentistry, Baltimore, MD, USA., Barouch DH; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Dhe-Paganon S; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Levy O; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT & Harvard, Cambridge, MA, USA., Frieman MB; Department of Microbiology and Immunology, The Center for Pathogen Research, University of Maryland School of Medicine, Baltimore, MD, USA., Dowling DJ; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA. david.dowling@childrens.harvard.edu.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA. david.dowling@childrens.harvard.edu.

Publikováno v: Communications biology [Commun Biol] 2022 Aug 06; Vol. 5 (1), pp. 790. Date of Electronic Publication: 2022 Aug 06.

An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity.

Autor: Borriello F; Harvard Medical School, Boston, MA, USA; Boston Children's Hospital, Division of Immunology, Boston, MA, USA; Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy., Poli V; Harvard Medical School, Boston, MA, USA; Boston Children's Hospital, Division of Immunology, Boston, MA, USA., Shrock E; Harvard Medical School, Boston, MA, USA; Howard Hughes Medical Institute, Division of Genetics, Brigham and Women's Hospital, Program in Virology, Boston, MA, USA., Spreafico R; Institute for Quantitative and Computational Biosciences, University of California, Los Angeles, Los Angeles, CA, USA., Liu X; Harvard Medical School, Boston, MA, USA; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA., Pishesha N; Harvard Medical School, Boston, MA, USA; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA., Carpenet C; Harvard Medical School, Boston, MA, USA; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA., Chou J; Harvard Medical School, Boston, MA, USA; Boston Children's Hospital, Division of Immunology, Boston, MA, USA., Di Gioia M; Harvard Medical School, Boston, MA, USA; Boston Children's Hospital, Division of Immunology, Boston, MA, USA., McGrath ME; University of Maryland School of Medicine, Department of Microbiology and Immunology, Baltimore, MD, USA., Dillen CA; University of Maryland School of Medicine, Department of Microbiology and Immunology, Baltimore, MD, USA., Barrett NA; Harvard Medical School, Boston, MA, USA; Brigham and Women's Hospital, Division of Allergy and Clinical Immunology, Boston, MA, USA., Lacanfora L; Harvard Medical School, Boston, MA, USA; Boston Children's Hospital, Division of Immunology, Boston, MA, USA; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy., Franco ME; Harvard Medical School, Boston, MA, USA; Boston Children's Hospital, Division of Immunology, Boston, MA, USA; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy., Marongiu L; Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy., Iwakura Y; Center for Animal Disease Models, Research Institute for Biomedical Sciences, Tokyo University of Science, Tokyo, Japan., Pucci F; Department of Otolaryngology-Head and Neck Surgery, Department of Cell, Developmental & Cancer Biology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA., Kruppa MD; Department of Biomedical Sciences, Quillen College of Medicine, Center of Excellence in Inflammation, Infectious Disease and Immunity, East Tennessee State University, Johnson City, TN, USA., Ma Z; Department of Surgery, Quillen College of Medicine, Center of Excellence in Inflammation, Infectious Disease and Immunity, East Tennessee State University, Johnson City, TN, USA., Lowman DW; Department of Surgery, Quillen College of Medicine, Center of Excellence in Inflammation, Infectious Disease and Immunity, East Tennessee State University, Johnson City, TN, USA., Ensley HE; Department of Surgery, Quillen College of Medicine, Center of Excellence in Inflammation, Infectious Disease and Immunity, East Tennessee State University, Johnson City, TN, USA., Nanishi E; Harvard Medical School, Boston, MA, USA; Boston Children's Hospital, Precision Vaccines Program, Boston, MA, USA., Saito Y; Boston Children's Hospital, Precision Vaccines Program, Boston, MA, USA., O'Meara TR; Boston Children's Hospital, Precision Vaccines Program, Boston, MA, USA., Seo HS; Harvard Medical School, Boston, MA, USA; Dana-Farber Cancer Institute, Department of Cancer Biology, Boston, MA, USA., Dhe-Paganon S; Harvard Medical School, Boston, MA, USA; Dana-Farber Cancer Institute, Department of Cancer Biology, Boston, MA, USA., Dowling DJ; Harvard Medical School, Boston, MA, USA; Boston Children's Hospital, Precision Vaccines Program, Boston, MA, USA., Frieman M; University of Maryland School of Medicine, Department of Microbiology and Immunology, Baltimore, MD, USA., Elledge SJ; Harvard Medical School, Boston, MA, USA; Howard Hughes Medical Institute, Division of Genetics, Brigham and Women's Hospital, Program in Virology, Boston, MA, USA., Levy O; Harvard Medical School, Boston, MA, USA; Boston Children's Hospital, Precision Vaccines Program, Boston, MA, USA; Broad Institute of MIT & Harvard, Cambridge, MA, USA., Irvine DJ; Massachusetts Institute of Technology, Department of Biological Engineering and Department of Materials Science and Engineering, Koch Institute for Integrative Cancer Research, Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Ploegh HL; Harvard Medical School, Boston, MA, USA; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA., Williams DL; Department of Biomedical Sciences, Quillen College of Medicine, Center of Excellence in Inflammation, Infectious Disease and Immunity, East Tennessee State University, Johnson City, TN, USA., Zanoni I; Harvard Medical School, Boston, MA, USA; Boston Children's Hospital, Division of Immunology, Boston, MA, USA; Boston Children's Hospital, Division of Gastroenterology, Boston, MA, USA. Electronic address: ivan.zanoni@childrens.harvard.edu.

Publikováno v: Cell [Cell] 2022 Feb 17; Vol. 185 (4), pp. 614-629.e21. Date of Electronic Publication: 2022 Feb 10.

Epicutaneous Staphylococcus aureus induces IL-36 to enhance IgE production and ensuing allergic disease.

Autor: Patrick GJ; Department of Dermatology and., Liu H; Department of Dermatology and., Alphonse MP; Department of Dermatology and., Dikeman DA; Department of Dermatology and., Youn C; Department of Dermatology and., Otterson JC; Department of Dermatology and., Wang Y; Department of Dermatology and., Ravipati A; Department of Dermatology and., Mazhar M; Department of Dermatology and., Denny G; Department of Dermatology and., Ortines RV; Department of Dermatology and., Zhang E; Department of Dermatology and., Miller RJ; Department of Dermatology and., Dillen CA; Department of Dermatology and., Liu Q; Department of Dermatology and., Nolan SJ; Department of Dermatology and., Nguyen K; Department of Dermatology and., Marcello L; Department of Dermatology and., Do DC; Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Wier EM; Department of Dermatology and., Zhang Y; Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Caviness G; Immunology & Respiratory Diseases Research, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, USA., Klimowicz AC; Immunology & Respiratory Diseases Research, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, USA., Mierz DV; Immunology & Respiratory Diseases Research, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, USA., Fine JS; Immunology & Respiratory Diseases Research, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, USA., Sun G; Laboratory of Allergic Diseases, NIAID, NIH, Bethesda, Maryland, USA., Goldbach-Mansky R; Translational Autoinflammatory Disease Section (TADS), NIAID, NIH, Bethesda, Maryland, USA., Marusina AI; Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, California, USA., Merleev AA; Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, California, USA., Maverakis E; Department of Dermatology, School of Medicine, University of California, Davis, Sacramento, California, USA., Garza LA; Department of Dermatology and., Milner JD; Department of Pediatrics, Columbia University Irving Medical Center, New York, New York, USA., Gao P; Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Ramanujam M; Immunology & Respiratory Diseases Research, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, USA., Raymond EL; Immunology & Respiratory Diseases Research, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, USA., Archer NK; Department of Dermatology and., Miller LS; Department of Dermatology and.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2021 Mar 01; Vol. 131 (5).

Interleukin-1β and tumor necrosis factor are essential in controlling an experimental orthopedic implant-associated infection.

Autor: Wang Y; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Ashbaugh AG; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Dikeman DA; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Zhang J; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Ackerman NE; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Kim SE; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Falgons C; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Ortines RV; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Liu H; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Joyce DP; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Alphonse MP; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Dillen CA; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Thompson JM; Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Archer NK; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland., Miller LS; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, Maryland.; Janssen Research and Development, Spring House, Pennsylvania.

Publikováno v: Journal of orthopaedic research : official publication of the Orthopaedic Research Society [J Orthop Res] 2020 Aug; Vol. 38 (8), pp. 1800-1809. Date of Electronic Publication: 2020 Feb 05.

Specimen Collection for Translational Studies in Hidradenitis Suppurativa.

Autor: Byrd AS; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA. angel_byrd@alumni.brown.edu.; Department of Dermatology, Howard University College of Medicine, Washington, DC, 20060, USA. angel_byrd@alumni.brown.edu., Dina Y; Meharry Medical College, Nashville, TN, 37208, USA., Okoh UJ; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA., Quartey QQ; University of Maryland School of Medicine, Baltimore, MD, 21201, USA., Carmona-Rivera C; Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Williams DW; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.; Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA., Kerns ML; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA., Miller RJ; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA., Petukhova L; Departments of Dermatology and Epidemiology, Columbia University, New York, NY, 10032, USA., Naik HB; Program for Clinical Research, Department of Dermatology, University of California San Francisco, San Francisco, CA, 94143-0808, USA., Barnes LA; Stanford University School of Medicine, Stanford, CA, 94305, USA., Shipman WD; Weill Cornell/Rockefeller/Sloan-Kettering Tri-Institutional MD-PhD Program, New York, NY, 10065, USA., Caffrey JA; Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA., Sacks JM; Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA., Milner SM; Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA., Aliu O; Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA., Broderick KP; Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA., Kim D; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA., Liu H; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA., Dillen CA; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA., Ahn R; Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, CA, 90095, USA., Frew JW; Department of Dermatology, Liverpool Hospital, Sydney, NSW, 2170, Australia.; Ingham Institute of Applied Medical Research, Liverpool, Sydney, NSW, 2170, Australia.; University of New South Wales, Sydney, NSW, 2033, Australia., Kaplan MJ; Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 20892, USA., Kang S; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA., Garza LA; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA., Miller LS; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA., Alavi A; Department of Medicine (Dermatology), University of Toronto, Toronto, Ontario, M1C 1A4, Canada.; Division of Dermatology, Women's College Hospital, Toronto, ON, M5S 1B2, Canada., Lowes MA; The Rockefeller University, New York, NY, 10065, USA., Okoye GA; Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.; Department of Dermatology, Howard University College of Medicine, Washington, DC, 20060, USA.

Publikováno v: Scientific reports [Sci Rep] 2019 Aug 21; Vol. 9 (1), pp. 12207. Date of Electronic Publication: 2019 Aug 21.