Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Dilip K. Challa"'
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-6 (2017)
The depletion of antigen-specific, deleterious antibodies during therapy and diagnosis remains an unsolved challenge. Here the authors develop ‘Seldegs’, antigens linked to human Fc fragments with high affinity for the neonatal Fc receptor FcRn,
Externí odkaz:
https://doaj.org/article/7077cda82f6d4593beeed48ce19dff2c
Two-color live cell imaging of a J774A.1 macrophage phagocytosing MDA-MB-453 cancer cells. Macrophages with surface-labeled CD45 (green) engulf three trastuzumab-opsonized MDA-MB-453 cells (red). Time is indicated at the top left in minutes:seconds f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bb6bad3220ce20d8ba2f3fb507d1c32
https://doi.org/10.1158/1535-7163.22506069.v1
https://doi.org/10.1158/1535-7163.22506069.v1
Document containing supplementary methods, supplementary figure legends for supplementary movies and figures; Figure S1. Harvesting efficiency of cancer cells in macrophage:cancer cell co-cultures; Figure S2. Macrophage-mediated reduction of opsonize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::285e9703e3d7d65438339efc3723743e
https://doi.org/10.1158/1535-7163.22506051.v1
https://doi.org/10.1158/1535-7163.22506051.v1
Autor:
Wei Sun, Benjamin Greenberg, Priyanka Khare, E. Sally Ward, Raimund J. Ober, Dilip K. Challa, Xiaoli Wang
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy, vol 29, iss 3
Current treatments for antibody-mediated autoimmunity are associated with lack of specificity, leading to immunosuppressive effects. To overcome this limitation, we have developed a class of antibody-based therapeutics for the treatment of autoimmuni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5689726460cc1dc21ac2645383a13f92
https://eprints.soton.ac.uk/446058/
https://eprints.soton.ac.uk/446058/
Autor:
Dilip K. Challa, E. Sally Ward, Xiaoli Wang, Héctor Perez Montoyo, Raimund J. Ober, Ramraj Velmurugan
Publikováno v:
mAbs
The maintenance of the homeostasis of immunoglobulin G (IgG) represents a fundamental aspect of humoral immunity that has direct relevance to the successful delivery of antibody-based therapeutics. The ubiquitously expressed neonatal Fc receptor (FcR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dcedc690b86bb07e096ea8f02938100
https://eprints.soton.ac.uk/430780/
https://eprints.soton.ac.uk/430780/
Autor:
Samuel Hughes, Benjamin Greenberg, Siva Charan Devanaboyina, Raimund J. Ober, E. Sally Ward, Dilip K. Challa, Priyanka Khare, Ramraj Velmurugan
Myelin oligodendrocyte glycoprotein (MOG) is exposed on the outer surface of the myelin sheath, and as such, represents a possible target antigen for antibodies in multiple sclerosis (MS) and other demyelinating diseases. However, despite extensive a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::305f3d1cc7ef03223753d19aebe70b68
https://eprints.soton.ac.uk/423685/
https://eprints.soton.ac.uk/423685/
Autor:
Dilip K. Challa, Pankaj Bansal, E. Sally Ward, Tarique Khan, Raimund J. Ober, Rafal Swiercz, Uta Bussmeyer, Ramraj Velmurugan
Publikováno v:
The Journal of Immunology. 191:1091-1101
Although Abs specific for myelin oligodendrocyte glycoprotein (MOG) have been detected in patients with multiple sclerosis (MS), their contribution to pathogenesis remains poorly understood. Immunization of C57BL/6 mice with recombinant human MOG (hM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37780432fe16ff2f469c9240ef8639a7
https://doi.org/10.4049/jimmunol.1300019
https://doi.org/10.4049/jimmunol.1300019
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-6 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-6 (2017)
Here we have designed a novel class of engineered antibody-based reagents (‘Seldegs') that induce the selective degradation of antigen-specific antibodies. We demonstrate the rapid and specific clearance of antibodies recognizing the autoantigen, m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cf717a698fcb17a5ca9aaf08751b20f
https://pubmed.ncbi.nlm.nih.gov/28561044
https://pubmed.ncbi.nlm.nih.gov/28561044
Publikováno v:
Journal of autoimmunity. 72
Antigen-specific T cell tolerance holds great promise for the treatment of autoimmune diseases. However, strategies to induce durable tolerance using high doses of soluble antigen have to date been unsuccessful, due to lack of efficacy and the risk o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33c50626937a771e0ac346c438398a12
https://pubmed.ncbi.nlm.nih.gov/27236506
https://pubmed.ncbi.nlm.nih.gov/27236506
Autor:
Alberto Puig-Canto, Dipesh A. Patel, E. Sally Ward, Raimund J. Ober, Dilip K. Challa, Héctor Perez Montoyo
Publikováno v:
The Journal of Immunology. 187:1015-1022
Multiple autoimmune diseases are characterized by the involvement of autoreactive Abs in pathogenesis. Problems associated with existing therapeutics such as the delivery of intravenous immunoglobulin have led to interest in developing alternative ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2184d9981943ccde5896bdd3d8b57cb5
https://doi.org/10.4049/jimmunol.1003780
https://doi.org/10.4049/jimmunol.1003780