Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Dilip D. Vakharia"'
Autor:
David C. Spink, Brian T. Pentecost, Laurence S. Kaminsky, Barbara C. Spink, Mirza M. Hussain, Dilip D. Vakharia, Susan J. Wu
Publikováno v:
Toxicology and Applied Pharmacology. 226:213-224
The interactions of polycyclic aromatic hydrocarbons (PAH) and cytochromes P450 (CYP) are complex; PAHs are enzyme inducers, substrates, and inhibitors. In T-47D breast cancer cells, exposure to 0.1 to 1 microM benzo(k)fluoranthene (BKF) induced CYP1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba060bc2560057fe96de603d27371e4
https://doi.org/10.1016/j.taap.2007.08.024
https://doi.org/10.1016/j.taap.2007.08.024
Publikováno v:
The American Journal of Pathology. 169:223-232
We have examined the development and transgene expression in liver lesions of transgenic mice bearing the hepatitis B surface antigen (HBsAg) gene of hepatitis B virus under the control of the albumin promoter (alb/psx) to study liver regeneration an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e9178057e0fd418362b7efe9dbd344
https://doi.org/10.2353/ajpath.2006.051284
https://doi.org/10.2353/ajpath.2006.051284
Autor:
Fassil B Mesfin, Robert MacColl, James A. Bennett, Gerald J. Mizejewski, Dilip D. Vakharia, Leslie E. Eisele, Herbert I. Jacobson, Thomas T. Andersen
Publikováno v:
The Journal of Peptide Research. 57:539-546
A 34-amino acid portion of the third domain of alpha-fetoprotein possesses antigrowth and anticancer activities. Three analogs of this sequence were chemically synthesized, in which the two cysteines of the original sequence were replaced by alanines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36051a9c110fe0d49fef4dcaf6ba4ad0
https://doi.org/10.1034/j.1399-3011.2001.00903.x
https://doi.org/10.1034/j.1399-3011.2001.00903.x
Autor:
Dilip D. Vakharia, Michael J. Fasco, Ronald Pause, Erin Bessette, Qing Yu Zhang, Laurence S. Kaminsky, Ning Liu
Publikováno v:
Toxicology and Applied Pharmacology. 170:93-103
Environmental cocontamination by polycyclic aromatic hydrocarbons (PAHs) and metals could affect the carcinogenic consequences of PAH exposure by modifying PAH induction of PAH-bioactivating CYP1A. The effect of As, Pb, Hg, or Cd (ranked as the most
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e709cfb0bb929b114cae4eeec49d74
https://doi.org/10.1006/taap.2000.9087
https://doi.org/10.1006/taap.2000.9087
Autor:
Dilip D. Vakharia, John F. Gierthy
Publikováno v:
Toxicology Letters. 114:55-65
Polychlorinated biphenyls (PCBs) are metabolized by hydroxylation; some of these hydroxylated metabolites exhibit estrogen-like activity in animal models. Because PCBs may have effects on human health, it is of interest to determine if human tissues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::698692f553fb0535fe872ce80b1ec038
https://doi.org/10.1016/s0378-4274(99)00194-0
https://doi.org/10.1016/s0378-4274(99)00194-0
Publikováno v:
Journal of Toxicology and Environmental Health, Part A. 59:197-210
Toxaphene is a complex mixture of chlorinated bornanes, bornenes, and bornadienes and was a heavily used insecticide in the United States until its use was restricted in 1982. There are conflicting reports regarding the potential for toxaphene to ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4646f04d5000959d82258c1db306b3c4
https://doi.org/10.1080/009841000156970
https://doi.org/10.1080/009841000156970
Autor:
David C. Spink, Richard F. Seegal, Karl O. Brosch, Liangdong Yi, Kathleen F. Arcaro, Yi Yang, Dilip D. Vakharia, John F. Gierthy
Publikováno v:
Journal of Cellular Biochemistry. 72:94-102
Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants whose effects on biological systems depend on the number of and the positions of the chlorine substitutions. In the present study we examined the estrogenicity of the fully or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4a5c7a6b33d0d09cedea0ed23a9fa56
https://doi.org/10.1002/(sici)1097-4644(19990101)72:1<94::aid-jcb10>3.0.co
https://doi.org/10.1002/(sici)1097-4644(19990101)72:1<94::aid-jcb10>3.0.co
Autor:
Kathleen F. Arcaro, William D. Niemi, Dilip D. Vakharia, S Pang, David O. Carpenter, Brian Bush
Publikováno v:
Environmental Health Perspectives
Unlike laboratory animals, people are rarely exposed to a single hazardous chemical. However, most of the information documenting adverse human health effects from environmental and occupational contaminants has come from studies focused on exposure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dcde9e315e170c34590b0883058ac23
https://doi.org/10.1289/ehp.98106s61263
https://doi.org/10.1289/ehp.98106s61263
Autor:
Robert F. Stack, Gerald J. Mizejewski, Charles R. Hauer, Adina Benno, Robert MacColl, Dilip D. Vakharia, Leslie E. Eisele, Wayne C. Kelly
Publikováno v:
Biochimica et biophysica acta. 1528(2-3)
A 34-amino-acid peptide has been chemically synthesized based on a sequence from human alpha-fetoprotein. The purified peptide is active in anti-growth assays when freshly prepared in pH 7.4 buffer at 0.20 g/l, but this peptide slowly becomes inactiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61af0138eeaee2b0b14d7117bb7edd67
https://pubmed.ncbi.nlm.nih.gov/11687299
https://pubmed.ncbi.nlm.nih.gov/11687299
Publikováno v:
Archives of biochemistry and biophysics. 389(1)
While fresh human hepatocyte cultures are widely used to model hepatic cytochrome P450 (CYP) regulation and activity, their CYP1A subfamily composition induced by, e.g., polycyclic aromatic hydrocarbons is ambiguous. CYP1A1, CYP1A2, or both have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24ff4df8ef5aeae676387ee4f86f8b1d
https://pubmed.ncbi.nlm.nih.gov/11370663
https://pubmed.ncbi.nlm.nih.gov/11370663