Výsledky vyhledávání - "Dilek, Iusuf"

Akademický článek

Organic anion-transporting polypeptide 2B1 knockout and humanized mice; insights into the handling of bilirubin and drugs

Autor: Wenlong Li, Dilek Iusuf, Rolf W. Sparidans, Els Wagenaar, Yaogeng Wang, Dirk R. de Waart, Margarida L.F. Martins, Stéphanie van Hoppe, Maria C. Lebre, Olaf van Tellingen, Jos H. Beijnen, Alfred H. Schinkel

Publikováno v: Pharmacological Research, Vol 190, Iss , Pp 106724- (2023)

Organic anion transporting polypeptide 2B1 (OATP2B1/SLCO2B1) facilitates uptake transport of structurally diverse endogenous and exogenous compounds. To investigate the roles of OATP2B1 in physiology and pharmacology, we established and characterized

Externí odkaz: https://doaj.org/article/f8d2c24093e5489fb6812b02a2a65cfa

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Supplementary Figures 1 through 3 and Supplementary Tables 1 through 3 from OATP1A/1B Transporters Affect Irinotecan and SN-38 Pharmacokinetics and Carboxylesterase Expression in Knockout and Humanized Transgenic Mice

Autor: Alfred H. Schinkel, Olaf van Tellingen, Fan Lin, Martin van der Valk, Els Wagenaar, Evita van de Steeg, Anita van Esch, Ahmed Elbatsh, Marion Ludwig, Dilek Iusuf

PDF - 278KB, Supplemental figure 1. pH equilibrium between the lactone (closed ring) form and free carboxylic acid (open) form of irinotecan and SN-38. Supplemental Figure 2. Role of Oatp1a/1b uptake transporters in small intestinal (tissue plus cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::638cae802c59446336feae0b2f280b61
https://doi.org/10.1158/1535-7163.22500156.v1

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Data from OATP1A/1B Transporters Affect Irinotecan and SN-38 Pharmacokinetics and Carboxylesterase Expression in Knockout and Humanized Transgenic Mice

Autor: Alfred H. Schinkel, Olaf van Tellingen, Fan Lin, Martin van der Valk, Els Wagenaar, Evita van de Steeg, Anita van Esch, Ahmed Elbatsh, Marion Ludwig, Dilek Iusuf

Organic anion-transporting polypeptides (OATP) mediate the hepatic uptake of many drugs, thus codetermining their clearance. Impaired hepatic clearance due to low-activity polymorphisms in human OATP1B1 may increase systemic exposure to SN-38, the ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7919a874f439756c790a463f50f88691
https://doi.org/10.1158/1535-7163.c.6536373.v1

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Human OATP1B1, OATP1B3 and OATP1A2 can mediate thein vivouptake and clearance of docetaxel

Autor: Alfred H. Schinkel, Jos H. Beijnen, Evita van de Steeg, Dilek Iusuf, Jeroen J M A Hendrikx, Hilde Rosing, Anita van Esch, Els Wagenaar

Publikováno v: International Journal of Cancer. 136:225-233

Organic anion transporting polypeptides (human: OATPs and mouse: Oatps) are uptake transporters with important roles in drug pharmacokinetics and toxicity. We aimed to study the in vivo impact of mouse and human OATP1A/1B transporters on docetaxel pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cd2d07287dcfceda430e4533f6993081
https://doi.org/10.1002/ijc.28970

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Hepatocyte Hopping of OATP1B Substrates Contributes to Efficient Hepatic Detoxification

Autor: Dilek Iusuf, Alfred H. Schinkel, E. van de Steeg

Publikováno v: Clinical Pharmacology & Therapeutics. 92:559-562

Human organic anion–transporting polypeptides (OATP)1B1 and OATP1B3 are major drug uptake transporters present in the basolateral (sinusoidal) membrane of hepatocytes. Owing to their broad substrate specificity, they have a major impact on the hepa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2c558c1174d71000a11e371b86a5e0c
https://doi.org/10.1038/clpt.2012.143

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Organic Anion-Transporting Polypeptides 1a/1b Control the Hepatic Uptake of Pravastatin in Mice

Autor: Rolf W. Sparidans, Evita van de Steeg, Els Wagenaar, Dilek Iusuf, Michael J Hobbs, Alfred H. Schinkel, Jos H. Beijnen, Anita van Esch, Kathryn E. Kenworthy

Publikováno v: Molecular Pharmaceutics. 9:2497-2504

Organic anion-transporting polypeptides (OATPs) mediate the hepatic uptake of many drugs. Hepatic uptake is crucial for the therapeutic effect of pravastatin, a cholesterol-lowering drug and OATP1A/1B substrate. We aimed to gain empirical insight int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b91ed806ae54f21a827b6fcad22a361
https://doi.org/10.1021/mp300108c

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Differential Impact of P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) on Axitinib Brain Accumulation and Oral Plasma Pharmacokinetics

Autor: Rolf W. Sparidans, Els Wagenaar, Dilek Iusuf, Alfred H. Schinkel, Jos H. Beijnen, Birk Poller

Publikováno v: Drug Metabolism and Disposition. 39:729-735

The second-generation tyrosine kinase inhibitor and anticancer drug axitinib is a potent, orally active inhibitor of the vascular endothelial growth factor receptors 1, 2, and 3. Axitinib has clinical activity against solid tumors such as metastatic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfe5d243550e14773616590a58401dc3
https://doi.org/10.1124/dmd.110.037317

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Angiotensin-(1–7): Pharmacological properties and pharmacotherapeutic perspectives

Autor: Dilek Iusuf, Robert H. Henning, Wiek H. van Gilst, Anton J.M. Roks

Publikováno v: European Journal of Pharmacology, 585(2-3), 303-312. Elsevier

Therapeutic modulation of the renin-angiotensin system is not complete without taking into consideration the beneficial effects of angiotensin-(1-7) in cardiovascular pathology. Various pharmacological pathways are already exploited to involve this h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a161b0a5ea95b53ee6a2c52c30df526
https://doi.org/10.1016/j.ejphar.2008.02.090

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