Mapping medically relevant RNA isoform diversity in the aged human frontal cortex with deep long-read RNA-seq.

Autor: Aguzzoli Heberle B; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA.; Department of Neuroscience, College of Medicine, University of Kentucky, Lexington, KY, USA., Brandon JA; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA., Page ML; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA., Nations KA; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA., Dikobe KI; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA., White BJ; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA., Gordon LA; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA., Fox GA; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA.; Department of Neuroscience, College of Medicine, University of Kentucky, Lexington, KY, USA., Wadsworth ME; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA., Doyle PH; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA.; Department of Neuroscience, College of Medicine, University of Kentucky, Lexington, KY, USA., Williams BA; Department of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, KY, USA., Fox EJ; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA., Shantaraman A; Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA., Ryten M; UK Dementia Research Institute at The University of Cambridge, Cambridge, UK.; Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; Department of Genetics and Genomic Medicine, Great Ormond Street Institute of Child Health, University College London, London, UK., Goodwin S; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Ghiban E; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Wappel R; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Mavruk-Eskipehlivan S; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Miller JB; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA.; Division of Biomedical Informatics, Internal Medicine, College of Medicine, University of Kentucky, Lexington, KY, USA.; Department of Pathology and Laboratory Medicine, University of Kentucky, Lexington, KY, USA.; Microbiology, Immunology and Molecular Genetics, College of Medicine, University of Kentucky, Lexington, KY, USA., Seyfried NT; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA., Nelson PT; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA., Fryer JD; Department of Neuroscience, Mayo Clinic, Scottsdale, AZ, USA., Ebbert MTW; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA. mark.ebbert@uky.edu.; Department of Neuroscience, College of Medicine, University of Kentucky, Lexington, KY, USA. mark.ebbert@uky.edu.; Division of Biomedical Informatics, Internal Medicine, College of Medicine, University of Kentucky, Lexington, KY, USA. mark.ebbert@uky.edu.

Publikováno v: Nature biotechnology [Nat Biotechnol] 2024 May 22. Date of Electronic Publication: 2024 May 22.