Zobrazeno 1 - 10
of 809
pro vyhledávání: '"Dik‐Lung Ma"'
Publikováno v:
ChemPlusChem. 79(4)
"My motto is …︁ work hard and smart. Determination will keep you going." This and more about Dik-Lung Ma can be found on page 485.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::35dfb1f420263caaecf9dee3e3ee0573
https://pubmed.ncbi.nlm.nih.gov/31986692
https://pubmed.ncbi.nlm.nih.gov/31986692
Autor:
Hai-Jing Zhong, Wanhe Wang, Wei Zhou, Jia-Xin Liang, Yung-Chi Cheng, Dik-Lung Ma, Chung-Hang Leung
Publikováno v:
Genes and Diseases, Vol 10, Iss 5, Pp 1735-1738 (2023)
Externí odkaz:
https://doaj.org/article/8694749e0e4a40a29383069dddab752f
Publikováno v:
Genes and Diseases, Vol 9, Iss 6, Pp 1674-1688 (2022)
Triple-negative breast cancer (TNBC) is a highly aggressive and metastasizing cancer that has the worst prognosis out of all breast cancer subtypes. The epithelial–mesenchymal transition (EMT) and cancer stem cells (CSCs) have been proposed as impo
Externí odkaz:
https://doaj.org/article/7732a09d52a34fe0a939d0c908d9e7cc
Autor:
Chong Ning, Yuhan Jiao, Jiaqi Wang, Weiwei Li, Jingqiu Zhou, Yi-Chieh Lee, Dik-Lung Ma, Chung-Hang Leung, Rugang Zhu, Hui-Min David Wang
Publikováno v:
Food Science and Human Wellness, Vol 11, Iss 5, Pp 1121-1133 (2022)
ABSTRACT: Diabetes has become a global concern at present, among which type 2 diabetes mellitus (T2DM) accounts for approximately 90 %–95 % of patients. T2DM is a type of metabolic disorder syndrome that results from a genetic defect, and it is bas
Externí odkaz:
https://doaj.org/article/356a2da564b047f3874c5e607ca502c9
Autor:
Shasha Cheng, Guan-Jun Yang, Wanhe Wang, Ying-Qi Song, Chung-Nga Ko, Quanbin Han, Dik-Lung Ma, Chung-Hang Leung
Publikováno v:
Acta Materia Medica, Vol 1, Iss 2, Pp 197-211 (2022)
Enhancer of zeste homolog 2 (EZH2) is activated in breast cancer, particularly in triple-negative breast cancer (TNBC), and is critical for cell invasion. It interacts with embryonic ectoderm development (EED) in maintaining cancer stem cells (CSC) a
Externí odkaz:
https://doaj.org/article/f6467e5fd4954edcb87d4a5a67e130aa
Autor:
Sha-Sha Cheng, Yuan-Qing Qu, Jia Wu, Guan-Jun Yang, Hao Liu, Wanhe Wang, Qi Huang, Feng Chen, Guodong Li, Chun-Yuen Wong, Vincent Kam Wai Wong, Dik-Lung Ma, Chung-Hang Leung
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 3, Pp 1390-1405 (2022)
Cyclin-dependent kinase 9 (CDK9) activity is correlated with worse outcomes of triple-negative breast cancer (TNBC) patients. The heterodimer between CDK9 with cyclin T1 is essential for maintaining the active state of the kinase and targeting this p
Externí odkaz:
https://doaj.org/article/2d4ed931c7e146e492f221e5338d392d
Publikováno v:
ChemPlusChem [Chempluschem] 2014 Apr; Vol. 79 (4), pp. 485. Date of Electronic Publication: 2014 Apr 02.
Autor:
Guodong Li, Chung-Nga Ko, Dan Li, Chao Yang, Wanhe Wang, Guan-Jun Yang, Carmelo Di Primo, Vincent Kam Wai Wong, Yaozu Xiang, Ligen Lin, Dik-Lung Ma, Chung-Hang Leung
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Impaired wound healing is a serious complication in diabetic patients, and is associated with reduced HIF1α stability. Here, the authors design a small molecule that stabilizes HIF1α by blocking its interaction with VHL and show that it promotes wo
Externí odkaz:
https://doaj.org/article/ab01c58730bb45109483db19c65692d4
Autor:
Guan-Jun Yang, Ming-Hui Zhu, Xin-Jiang Lu, Yan-Jun Liu, Jian-Fei Lu, Chung-Hang Leung, Dik-Lung Ma, Jiong Chen
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-18 (2021)
Abstract Histone methylation is a key posttranslational modification of chromatin, and its dysregulation affects a wide array of nuclear activities including the maintenance of genome integrity, transcriptional regulation, and epigenetic inheritance.
Externí odkaz:
https://doaj.org/article/2b51ebdc6f224925a16ecfecb465bb26
Publikováno v:
Journal of Hematology & Oncology, Vol 13, Iss 1, Pp 1-14 (2020)
Abstract Protein-protein interactions (PPIs) are central to a variety of biological processes, and their dysfunction is implicated in the pathogenesis of a range of human diseases, including cancer. Hence, the inhibition of PPIs has attracted signifi
Externí odkaz:
https://doaj.org/article/e2d047b6c9634943a18bd1899f69e0c1