Immunogenicity and reactogenicity of intradermal mRNA-1273 SARS-CoV-2 vaccination: a non-inferiority, randomized-controlled trial.

Autor: Prins MLM; Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands., Roozen GVT; Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.; Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands., Pothast CR; Department of Haematology, Leiden University Medical Center, Leiden, The Netherlands., Huisman W; Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands., van Binnendijk R; Department of Immune Surveillance, National Institute for Public Health and the Environment, Bilthoven, The Netherlands., den Hartog G; Department of Immune Surveillance, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.; Laboratory of Medical Immunology, RadboudUMC, Nijmegen, The Netherlands., Kuiper VP; Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands., Prins C; Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands., Janse JJ; Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands., Lamers OAC; Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands., Koopman JPR; Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands., Kruithof AC; Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.; Center for Human Drug Research, Leiden, The Netherlands., Kamerling IMC; Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.; Center for Human Drug Research, Leiden, The Netherlands., Dijkland RC; Department of Haematology, Leiden University Medical Center, Leiden, The Netherlands., de Kroon AC; Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands., Azimi S; Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands., Feltkamp MCW; Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands., Kuijer M; Department of Immune Surveillance, National Institute for Public Health and the Environment, Bilthoven, The Netherlands., Jochems SP; Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands., Heemskerk MHM; Department of Haematology, Leiden University Medical Center, Leiden, The Netherlands., Rosendaal FR; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Roestenberg M; Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.; Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands., Visser LG; Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands., Roukens AHE; Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands. a.h.e.roukens@lumc.nl.

Publikováno v: NPJ vaccines [NPJ Vaccines] 2024 Jan 02; Vol. 9 (1), pp. 1. Date of Electronic Publication: 2024 Jan 02.

SARS-CoV-2-specific CD4 ⁺ and CD8 ⁺ T cell responses can originate from cross-reactive CMV-specific T cells.

Autor: Pothast CR; Department of Hematology, Leiden University Medical Center, Leiden, Netherlands., Dijkland RC; Department of Hematology, Leiden University Medical Center, Leiden, Netherlands., Thaler M; Department of Medical Microbiology, Leiden University Medical Center, Leiden, Netherlands., Hagedoorn RS; Department of Hematology, Leiden University Medical Center, Leiden, Netherlands., Kester MGD; Department of Hematology, Leiden University Medical Center, Leiden, Netherlands., Wouters AK; Department of Hematology, Leiden University Medical Center, Leiden, Netherlands., Hiemstra PS; Department of Pulmonology, Leiden University Medical Center, Leiden, Netherlands., van Hemert MJ; Department of Medical Microbiology, Leiden University Medical Center, Leiden, Netherlands., Gras S; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Victoria, Australia.; Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia., Falkenburg JHF; Department of Hematology, Leiden University Medical Center, Leiden, Netherlands., Heemskerk MHM; Department of Hematology, Leiden University Medical Center, Leiden, Netherlands.

Publikováno v: ELife [Elife] 2022 Nov 21; Vol. 11. Date of Electronic Publication: 2022 Nov 21.

Tetanus-diphtheria vaccine can prime SARS-CoV-2 cross-reactive T cells.

Autor: Fernandez, Sara Alonso, Pelaez-Prestel, Hector F., Fiyouzi, Tara, Gomez-Perosanz, Marta, Reiné, Jesús, Reche, Pedro A.

Publikováno v: Frontiers in Immunology; 2024, p1-15, 15p

High frequencies of alpha common cold coronavirus/SARSCoV-2 cross-reactive functional CD4⁺ and CD8⁺ memory T cells are associated with protection from symptomatic and fatal SARS-CoV-2 infections in unvaccinated COVID-19 patients.

Autor: Coulon, Pierre-Gregoire, Prakash, Swayam, Dhanushkodi, Nisha R., Srivastava, Ruchi, Zayou, Latifa, Tifrea, Delia F., Edwards, Robert A., Figueroa, Cesar J., Schubl, Sebastian D., Hsieh, Lanny, Nesburn, Anthony B., Kuppermann, Baruch D., Bahraoui, Elmostafa, Vahed, Hawa, Gil, Daniel, Jones, Trevor M., Ulmer, Jeffrey B., BenMohamed, Lbachir

Publikováno v: Frontiers in Immunology; 2024, p1-26, 26p