Ex vivo fluorescence-guided resection margin assessment in breast cancer surgery using a topically applied, cathepsin-activatable imaging agent.

Autor: Linders DGJ; Department of Surgery, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands., Bijlstra OD; Department of Surgery, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands., Walker E; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA., March TL; Department of Surgery, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands., Pool M; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands., Valentijn ARPM; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands., Dijkhuis TH; Department of Surgery, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands., Woltering JN; Department of Surgery, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands., Pijl FR; Department of Surgery, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands., Noordam G; Department of Pathology, Haaglanden Medical Center, The Hague 2512 VA, The Netherlands., van den Burg D; Department of Pathology, Haaglanden Medical Center, The Hague 2512 VA, The Netherlands., van der Sijp JRM; Department of Surgery, Haaglanden Medical Center, The Hague 2512 VA, The Netherlands., Guicherit OR; Department of Surgery, Haaglanden Medical Center, The Hague 2512 VA, The Netherlands., Marinelli AWKS; Department of Surgery, Haaglanden Medical Center, The Hague 2512 VA, The Netherlands., Burggraaf J; Centre for Human Drug Research, Leiden 2333 CL, The Netherlands; Leiden Academic Center for Drug Research, Leiden University, Leiden 2300 RA, The Netherlands., Rissmann R; Centre for Human Drug Research, Leiden 2333 CL, The Netherlands; Leiden Academic Center for Drug Research, Leiden University, Leiden 2300 RA, The Netherlands., Bogyo M; Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA., Hilling DE; Department of Surgery, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands; Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam 3015 GD, The Netherlands., Kuppen PJK; Department of Surgery, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands., Straight B; Akrotome Imaging Inc., Cleveland, OH 44106, USA., Straver ME; Department of Surgery, Haaglanden Medical Center, The Hague 2512 VA, The Netherlands., Hazelbag HM; Department of Pathology, Haaglanden Medical Center, The Hague 2512 VA, The Netherlands., Basilion JP; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA; Akrotome Imaging Inc., Cleveland, OH 44106, USA; Department of Radiology, Case School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. Electronic address: jxb206@case.edu., Vahrmeijer AL; Department of Surgery, Leiden University Medical Center, Leiden 2333 ZA, The Netherlands. Electronic address: a.l.vahrmeijer@lumc.nl.

Publikováno v: Pharmacological research [Pharmacol Res] 2024 Nov; Vol. 209, pp. 107464. Date of Electronic Publication: 2024 Oct 12.

Fluorescence lifetime of injected indocyanine green as a universal marker of solid tumours in patients.

Autor: Pal R; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA., Lwin TM; Department of Surgical Oncology, City of Hope Hospital, Duarte, CA, USA., Krishnamoorthy M; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA., Collins HR; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA., Chan CD; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK., Prilutskiy A; Department of Pathology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Nasrallah MP; Department of Pathology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA., Dijkhuis TH; Department of Surgery, Leiden University Medical Center, Leiden, the Netherlands., Shukla S; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA., Kendall AL; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA., Marshall MS; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Carp SA; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA., Hung YP; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Shih AR; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Martinez-Lage M; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Zukerberg L; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Sadow PM; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Department of Otolaryngology and Head and Neck Surgery, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA., Faquin WC; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Department of Otolaryngology and Head and Neck Surgery, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA., Nahed BV; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Feng AL; Department of Otolaryngology and Head and Neck Surgery, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA., Emerick KS; Department of Otolaryngology and Head and Neck Surgery, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA., Mieog JSD; Department of Surgery, Leiden University Medical Center, Leiden, the Netherlands., Vahrmeijer AL; Department of Surgery, Leiden University Medical Center, Leiden, the Netherlands., Rajasekaran K; Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA, USA., Lee JYK; Department of Neurosurgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA., Rankin KS; The North of England Bone and Soft Tissue Tumour Service, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Lozano-Calderon S; Department of Orthopedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Varvares MA; Department of Otolaryngology and Head and Neck Surgery, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA., Tanabe KK; Division of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Kumar ATN; Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA. atkumar@mgh.harvard.edu.

Publikováno v: Nature biomedical engineering [Nat Biomed Eng] 2023 Dec; Vol. 7 (12), pp. 1649-1666. Date of Electronic Publication: 2023 Oct 16.