Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Dijie Li"'
Autor:
Chuanxin Zhong, Nanxi Li, Shengzheng Wang, Dijie Li, Zhihua Yang, Lin Du, Guangxin Huang, Haitian Li, Wing Sze Yeung, Shan He, Shuting Ma, Zhuqian Wang, Hewen Jiang, Huarui Zhang, Zhanghao Li, Xiaoxin Wen, Song Xue, Xiaohui Tao, Haorui Li, Duoli Xie, Yihao Zhang, Zefeng Chen, Junqin Wang, Jianfeng Yan, Zhengming Liang, Zongkang Zhang, Zhigang Zhong, Zeting Wu, Chao Wan, Chao Liang, Luyao Wang, Sifan Yu, Yuan Ma, Yuanyuan Yu, Fangfei Li, Yang Chen, Baoting Zhang, Aiping Lyu, Fuzeng Ren, Hong Zhou, Jin Liu, Ge Zhang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Excessive glucocorticoid (GC) action is linked to various metabolic disorders. Recent findings suggest that disrupting skeletal GC signaling prevents bone loss and alleviates metabolic disorders in high-fat diet (HFD)-fed obese mice, underpi
Externí odkaz:
https://doaj.org/article/4066e2b4eccd4e0695c1364b8d7b5dfd
Autor:
Tao Xiaohui, Luyao Wang, Xin Yang, Hewen Jiang, Ning Zhang, Huarui Zhang, Dijie Li, Xiaofei Li, Yihao Zhang, Shenghang Wang, Chuanxin Zhong, Sifan Yu, Meishen Ren, Meiheng Sun, Nanxi Li, Tienan Chen, Yuan Ma, Fangfei Li, Jin Liu, Yuanyuan Yu, Hua Yue, Zhenlin Zhang, Ge Zhang
Publikováno v:
Journal of Orthopaedic Translation, Vol 47, Iss , Pp 39-49 (2024)
Sclerostin emerges as a novel target for bone anabolic therapy in bone diseases. Osteogenesis imperfecta (OI) and X-linked hypophosphatemia (XLH) are rare bone diseases in which therapeutic potential of sclerostin inhibition cannot be ignored. In OI,
Externí odkaz:
https://doaj.org/article/af3deae3ca544e9785bfc76fae85e201
Autor:
Yuanyuan Yu, Luyao Wang, Shuaijian Ni, Dijie Li, Jin Liu, Hang Yin Chu, Ning Zhang, Meiheng Sun, Nanxi Li, Qing Ren, Zhenjian Zhuo, Chuanxin Zhong, Duoli Xie, Yongshu Li, Zong-Kang Zhang, Huarui Zhang, Mei Li, Zhenlin Zhang, Lin Chen, Xiaohua Pan, Weibo Xia, Shu Zhang, Aiping Lu, Bao-Ting Zhang, Ge Zhang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Antibodies targeting sclerostin can ameliorate postmenopausal osteoporosis but present some cardiovascular risk. Here the authors show that the cardiovascular and skeletal effects of sclerostin are mediated by different loops, suggesting ways to pres
Externí odkaz:
https://doaj.org/article/ff38f6e32b034261a6747ac670344b44
Autor:
Yang Wang, Shuhao Wang, Yanze Meng, Zhen Liu, Dijie Li, Yunyang Bai, Guoliang Yuan, Yaojin Wang, Xuehui Zhang, Xiaoguang Li, Xuliang Deng
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Tooth whitening becoming a common cosmetic treatment has led to the development of catalytic whitening solutions. Here, the authors report upon a thermally triggered, pyrocatalytic, catalyst which can use temperature changes from normal oral activity
Externí odkaz:
https://doaj.org/article/4f80c36efba540e79df2976d08a6ef5a
Autor:
Sifan Yu, Dijie Li, Ning Zhang, Shuaijian Ni, Meiheng Sun, Luyao Wang, Huan Xiao, Dingdong Liu, Jin Liu, Yuanyuan Yu, Zongkang Zhang, Samuel Tin Yui Yeung, Shu Zhang, Aiping Lu, Zhenlin Zhang, Baoting Zhang, Ge Zhang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 5, Pp 2150-2170 (2022)
Sclerostin, a protein secreted from osteocytes, negatively regulates the WNT signaling pathway by binding to the LRP5/6 co-receptors and further inhibits bone formation and promotes bone resorption. Sclerostin contributes to musculoskeletal system-re
Externí odkaz:
https://doaj.org/article/c0e2422c0f3d479ab42ed5320b3ed31a
Autor:
Lei Dang, Nanxi Li, Xiaohao Wu, Dijie Li, Zongkang Zhang, Bao- Zhang, Aiping Lyu, Lin Chen, Ge Zhang, Jin Liu
Publikováno v:
Bio-Protocol, Vol 12, Iss 5 (2022)
Osteoclast lineage cells (OLCs), including osteoclast precursors (OCPs) and mature osteoclasts (MOCs), participate in bone remodeling and mediate pathologic bone loss. Thus, it is essential to obtain OLCs for exploring their molecular features in bot
Externí odkaz:
https://doaj.org/article/fbbe422862b141e29509e6f725cc6230
Autor:
Chong Yin, Ye Tian, Dijie Li, Yang Yu, Shanfeng Jiang, Yimei Hou, Meng Deng, Kaiyuan Zheng, Yan Zhang, Xiaoni Deng, Zhihao Chen, Zhiping Miao, Qiang Hao, Yu Li, Airong Qian
Publikováno v:
iScience, Vol 25, Iss 3, Pp 103949- (2022)
Summary: Osteoporosis has become a high incident bone disease along with the aging of human population. Long noncoding RNAs (LncRNAs) play an important role in osteoporosis incidence. In this study, we screened out an LncRNA negatively correlated wit
Externí odkaz:
https://doaj.org/article/f4d75ca91cc64c789a6d06ce3bf3a496
Autor:
Chong Yin, Ye Tian, Yang Yu, Chaofei Yang, Peihong Su, Yipu Zhao, Xue Wang, Kewen Zhang, Jiawei Pei, Dijie Li, Zhihao Chen, Yan Zhang, Zhiping Miao, Airong Qian
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Osteoporosis is a frequently occurring bone disease in middle-aged and aged men and women. However, current therapies on this disease are still not ideal. MicroRNAs (miRNAs) are a class of endogenous non-protein-coding RNA with a length of 18–25 nu
Externí odkaz:
https://doaj.org/article/d8ab0c38406b4072b569f9cb53e9bed2
Publikováno v:
Biology Open, Vol 9, Iss 3 (2020)
Microtubule actin crosslinking factor 1 (MACF1) is a widely expressed cytoskeletal linker and plays an essential role in various cells’ functions by mediating cytoskeleton organization and dynamics. However, the role of MACF1 on preosteoblast migra
Externí odkaz:
https://doaj.org/article/52c9ae9b1bbc4956afed6907bb0b95f7
Publikováno v:
JBMR Plus, Vol 3, Iss 9, Pp n/a-n/a (2019)
ABSTRACT microRNA (miRNA)‐mediated regulation represents a highly efficient posttranscriptional mechanism for controlling intracellular protein expression. In the past decade, many studies have shown that various miRNAs are involved in regulating b
Externí odkaz:
https://doaj.org/article/dcafe5a462ee40b7b7ee4de5b7ebd04d