Identification of fungal dihydrouracil-oxidase genes by expression in Saccharomyces cerevisiae

Autor: Jonna Bouwknegt, Aurin M. Vos, Raúl A. Ortiz Merino, Daphne C. van Cuylenburg, Marijke A. H. Luttik, Jack T. Pronk

Publikováno v: Antonie van Leeuwenhoek: international journal of general and molecular microbiology, 115(11)

Analysis of predicted fungal proteomes revealed a large family of sequences that showed similarity to the Saccharomyces cerevisiae Class-I dihydroorotate dehydrogenase Ura1, which supports synthesis of pyrimidines under aerobic and anaerobic conditio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3104ca8874436e8599375f2f1ec5a422
http://resolver.tudelft.nl/uuid:485341ad-d201-424a-b17a-334397cb5287

Stereoisomeric C5-C5'-Linked Dihydrothymine Dimers Produced by Radiolytic One-Electron Reduction of Thymine Derivatives in Anoxic Aqueous Solution: Structural Characteristics in Reference to Cyclobutane Photodimers

Autor: Hiroshi Hatta, Takeo Ito, Hideki Shinohara, Sei-ichi Nishimoto

Publikováno v: The Journal of organic chemistry. 64(14)

Radiolytic one-electron reduction of 1-methylthymine (1a) and 1,3-dimethylthymine (1b) in anoxic aqueous solution afforded stereoisomeric C5−C5‘-linked dihydrothymine dimers, fractionated into the meso forms of (5R,5‘S)- and (5S,5‘R)-bi-5,6-d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f1de322c62b20d7939a3b25ce47b3d8
https://pubmed.ncbi.nlm.nih.gov/34237845

Clinical Significance of Screening Differential Metabolites in Ovarian Cancer Tissue and Ascites by LC/MS

Autor: Miao Liu, Yu Liu, Hua Feng, Yixin Jing, Shuang Zhao, Shujia Yang, Nan Zhang, Shi Jin, Yafei Li, Mingjiao Weng, Xinzhu Xue, Fuya Wang, Yongheng Yang, Xiaoming Jin, Dan Kong

Publikováno v: Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 12 (2021)

Tumor cells not only show a vigorous metabolic state, but also reflect the disease progression and prognosis from their metabolites. To judge the progress and prognosis of ovarian cancer is generally based on the formation of ascites, or whether ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab241926caeb9f95a9a84135c12b1776
https://pubmed.ncbi.nlm.nih.gov/34795577

Dihydropyrimidinase protects from DNA replication stress caused by cytotoxic metabolites

Autor: Zellweger, Ralph, Chauvin, Maëva, Bec, Nicole, Larroque, Christian, Lopes, Massimo, Basbous, Jihane, Aze, Antoine, CHALOIN, Laurent, Lebdy, Rana, Hodroj, Dana, Ribeyre, Cyril, Larroque, Marion, Shepard, Caitlin, Kim, Baek, Pruvost, Alain, Moreaux, Jérôme, Maiorano, Domenico, Méchali, Marcel, Constantinou, Angelos

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, 2020, 48 (4), pp.1886-1904. ⟨10.1093/nar/gkz1162⟩
Nucleic Acids Research, Oxford University Press, 2020, 48 (4), pp.1886-1904. ⟨10.1093/nar/gkz1162⟩

Metabolic alterations support cellular transformation. Noticeably, cellular transformation and cancer progression is associated with accumulation of dihydrouracil and dihydrothymine. However, it remains elusive how dihydropyrimidine metabolites affec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dcae2cf4dd3e7e5ccc59a4dd71160f1
https://hal.science/hal-02556387

Towards a test to predict 5-fluorouracil toxicity: Pharmacokinetic data for thymine and two sequential metabolites following oral thymine administration to healthy adult males

Autor: Scott Mead, Lesley Sheffield, André B.P. van Kuilenburg, Andrew Cameron, Ross Norris, Marion Harris, Bruce G. Charles, Rani George, Ming Ni, Catherine Shannon, John A. Duley, Nuala A. Helsby

Publikováno v: European journal of pharmaceutical sciences, 81, 36-41. Elsevier

The fluoropyrimidine drugs 5-fluorouracil and its oral prodrug capecitabine remain first line therapy for solid tumours of the neck, breast and colon. However, significant and unpredictable toxicity affects about 10–25% of patients depending upon t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0913bafa2f021e66bdedfe8f1dbc9035
https://doi.org/10.1016/j.ejps.2015.10.001