Zobrazeno 1 - 10
of 1 259
pro vyhledávání: '"Dihydrolipoyl transacetylase"'
Publikováno v:
Exploration of Immunology, Vol 4, Iss 5, Pp 624-639 (2024)
Primary biliary cholangitis (PBC) is a chronic cholestatic progressive liver disease associated with cholangiopathies. The detection of antimitochondrial autoantibodies (AMAs) plays an important role in the diagnosis of classical PBC. AMAs are formed
Externí odkaz:
https://doaj.org/article/f2ea29285cb34bb3be8fb8d9c7d53997
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nature Communications
Nat Commun
Nature Communications
Nat Commun
The pyruvate dehydrogenase complex (PDHc) links glycolysis to the citric acid cycle by converting pyruvate into acetyl-coenzyme A. PDHc encompasses three enzymatically active subunits, namely pyruvate dehydrogenase, dihydrolipoyl transacetylase, and
Autor:
Jia-Woei Hou, Tsann-Long Hwang
Publikováno v:
Pediatrics and Neonatology, Vol 55, Iss 3, Pp 213-217 (2014)
Maple syrup urine disease (MSUD) is a rare inborn error of metabolism caused by a deficiency of the branched-chain α-ketoacid dehydrogenase (BCKD) complex. Mutations in any one of the three different genes encoding for the BCKD components, namely, B
Externí odkaz:
https://doaj.org/article/3b33e0d5fb5a407c9fa381eb765c56ca
Autor:
Michael A. Moxley, Bodhi A. Jelinek
Publikováno v:
Biophys J
The mammalian pyruvate dehydrogenase complex (PDC) is a mitochondrial multienzyme complex that connects glycolysis to the tricarboxylic acid cycle by catalyzing pyruvate oxidation to produce acetyl-CoA, NADH, and CO(2). This reaction is required to a
Akademický článek
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Autor:
Ryuta Hayashi, Mitsuhiro Ueda, Shigeo Takenaka, Yoshihisa Nakano, Tatsuji Sakamoto, Hiroshi Inui, Takahiro Ishikawa, Kazutaka Miyatake, Masami Nakazawa
Publikováno v:
Bioscience, Biotechnology, and Biochemistry. 81:1386-1393
In Euglena gracilis, pyruvate:NADP+ oxidoreductase, in addition to the pyruvate dehydrogenase complex, functions for the oxidative decarboxylation of pyruvate in the mitochondria. Furthermore, the 2-oxoglutarate dehydrogenase complex is absent, and i
Autor:
Panneerselvan Logeshwaran, Kadiyala Venkateswarlu, Ravi Naidu, Mallavarapu Megharaj, Suresh R. Subashchandrabose
Publikováno v:
Algal Research. 23:223-232
Microalgae inhabiting the real contaminated sites are capable of degrading organic pollutants. In the present study, the potential of a microalga, Chlorella ssp. MM3, a soil isolate from a former cattle dip site, was assessed in degrading pyrene both
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 9, Iss 6, Pp 1183-1192 (2019)
Acta Pharmaceutica Sinica B, Vol 9, Iss 6, Pp 1183-1192 (2019)
Sirtuins (SIRTs) are nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylases with diverse physiological functions. A variety of small molecules have been developed to interrogate the physiological function of SIRTs. Therefore, it is d
Autor:
Matthew W. Powner, Adam J. Coggins
Publikováno v:
Nature Chemistry. 9:310-317
Phosphoenol pyruvate is the highest-energy phosphate found in living organisms and is one of the most versatile molecules in metabolism. Consequently, it is an essential intermediate in a wide variety of biochemical pathways, including carbon fixatio
Autor:
Gonzalo Perez-Siles, David T. Chuang, Alexander P. Drew, A.J. Grant, Marina L. Kennerson, Carolyn Ly, Garth A. Nicholson, Eppie M. Yiu, Shih Chia Tso, Monique M. Ryan
Publikováno v:
Neurobiology of Disease, Vol 94, Iss, Pp 237-244 (2016)
Charcot-Marie-Tooth disease (CMT) is the most common inherited peripheral neuropathy. An X-linked form of CMT (CMTX6) is caused by a missense mutation (R158H) in the pyruvate dehydrogenase kinase isoenzyme 3 (PDK3) gene. PDK3 is one of 4 isoenzymes t