Drug control of biofilm dispersion due to regulation of the activity of bacterial cyclic guanosine monophosphate (part 1)

Autor: А.Е. Abaturov

Publikováno v: CHILD`S HEALTH; Том 15, № 1 (2020); 60-67
Здоров'я дитини-Zdorovʹe rebenka; Том 15, № 1 (2020); 60-67
Здоровье ребенка-Zdorovʹe rebenka; Том 15, № 1 (2020); 60-67

The infectious process caused by pathogenic bacteria can be accompanied by the formation of a biofilm, which determines the safety of bacteria and a decrease in the effectiveness of antibacterial agents. The development of drugs that contribute to th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a76c9f38dc6374c9bfd8c553d4a577
https://doi.org/10.22141/2224-0551.15.1.2020.196759

Structure of the active GGEEF domain of a diguanylate cyclase from Vibrio cholerae

Autor: Sumit Biswas, Yvette Roske, Udo Heinemann, Om Prakash Chouhan

Publikováno v: Biochemical and Biophysical Research Communications. 523:287-292

Cyclic-di-GMP (c-di-GMP) synthesized by diguanylate cyclases has been an important and ubiquitous secondary messenger in almost all bacterial systems. In Vibrio cholerae, c-di-GMP plays an intricate role in the production of the exopolysaccharide mat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::405015c2ef4a8e8a332b7ed0d7f9ab0c
https://doi.org/10.1016/j.bbrc.2019.11.179

Bacterial cyclic diguanylate signaling networks sense temperature

Autor: Katherine Leblanc, Ian A. Lewis, Elise Granton, Ann Karen C. Brassinga, Henrik Almblad, Maria Silvina Stietz, Laura K. Jennings, Yuefei Lou, Julie Groizeleau, Bryan G. Yipp, Jacquelyn D. Rich, Fanny Liu, Ayush Kumar, Roger E. Bumgarner, Manu Singh, Nathan Good, Nicolas Fournier, Emily Au, Tara M.L. Winstone, Fiona S. L. Brinkman, Trevor E. Randall, Michael F. Hynes, Weerayuth Kittichotirat, Joe J. Harrison, Geoffrey L. Winsor, Ryan A. Groves, Justin L. MacCallum, Boo Shan Tseng, Matthew R. Parsek, Larissa A. Singletary

Publikováno v: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Many bacteria use the second messenger cyclic diguanylate (c-di-GMP) to control motility, biofilm production and virulence. Here, we identify a thermosensory diguanylate cyclase (TdcA) that modulates temperature-dependent motility, biofilm developmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7114bd3661533bb49ebeb868be7bc9ae
http://europepmc.org/articles/PMC8012707

The SiaA/B/C/D signaling network regulates biofilm formation in Pseudomonas aeruginosa

Autor: Gukui Chen, Weiping Huo, Chun Yang, Haihua Liang, Tietao Wang, Juan Peng, Jianhua Gan, Yili Zuo, Yingpeng Xie, Meng Li, Yani Zhang, Xin Deng

Publikováno v: EMBO J

Bacterial cyclic-di-GMP (c-di-GMP) production is associated with biofilm development and the switch from acute to chronic infections. In Pseudomonas aeruginosa, the diguanylate cyclase (DGC) SiaD and phosphatase SiaA, which are co-transcribed as part

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b54fd030a26264c7aab022b9d1984b0c
https://doi.org/10.15252/embj.2019103412

Bordetella bronchiseptica Diguanylate Cyclase BdcA Regulates Motility and Is Important for the Establishment of Respiratory Infection in Mice

Autor: Kurt M. Dahlstrom, Federico Sisti, Dawn Taylor, Federico Zacca, Nicolás Martín Ambrosis, María de la Paz Gutierrez, Eric T. Harvill, Keila Belhart, George A. O'Toole, Julieta Fernández, Monica Cartelle Gestal

Publikováno v: SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP

Bacteria can be motile and planktonic or, alternatively, sessile and participating in the biofilm mode of growth. The transition between these lifestyles can be regulated by a second messenger, cyclic dimeric GMP (c-di-GMP). High intracellular c-diGM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8fa86f8b22ebcd135ffaead2a56a541
https://europepmc.org/articles/PMC6689298/