Helicobacter pylori initiates successful gastric colonization by utilizing L-lactate to promote complement resistance

Autor: Shuai Hu, Karen M. Ottemann

Publikováno v: Nature communications, vol 14, iss 1

The complement system has long been appreciated for its role in bloodborne infections, but its activities in other places, including the gastrointestinal tract, remain elusive. Here, we report that complement restricts gastric infection by the pathog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaaa82b797bfa5605f81818d08319d9c
https://escholarship.org/uc/item/12j4k95h

Altered Gastric Microbiota and Inflammatory Cytokine Responses in Patients with Helicobacter pylori-Negative Gastric Cancer

Autor: Han-Na Kim, Min-Jeong Kim, Jonathan P. Jacobs, Hyo-Joon Yang

Publikováno v: Nutrients; Volume 14; Issue 23; Pages: 4981
Nutrients, vol 14, iss 23

The role of the gastric mucosal microbiome in Helicobacter pylori-negative gastric cancer (GC) remains unclear. Therefore, we aimed to characterize the microbial alterations and host inflammatory cytokine responses in H. pylori-negative GC. Gastric m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81c1b39ea9efe5db24840fb076c4f09e

'True' Helicobacter pylori infection and non-cardia gastric cancer: A pooled analysis within the Stomach Cancer Pooling (StoP) Project

Autor: Samantha Morais, Adriana Costa, Gabriela Albuquerque, Natália Araújo, Shoichiro Tsugane, Akihisa Hidaka, Gerson Shigueaki Hamada, Weimin Ye, Amelie Plymoth, Marcis Leja, Evita Gasenko, David Zaridze, Dmitry Maximovich, Reza Malekzadeh, Mohammad H. Derakhshan, Claudio Pelucchi, Eva Negri, M. Constanza Camargo, Maria Paula Curado, Jesus Vioque, Zuo‐Feng Zhang, Carlo La Vecchia, Paolo Boffetta, Nuno Lunet

Publikováno v: Helicobacter, vol 27, iss 3
HELICOBACTER
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname

Background: \ud Helicobacter pylori is the most important risk factor for non-cardia gastric cancer (NCGC); however, the magnitude of the association varies across epidemiological studies. This study aimed to quantify the association between H. pylor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f53770142ba24d84359a1f2230954901
https://pubmed.ncbi.nlm.nih.gov/35235224

Cryo-EM structures of Helicobacter pylori vacuolating cytotoxin A oligomeric assemblies at near-atomic resolution

Autor: Grigore D. Pintilie, Michael F. Schmid, Huina Zhang, S.W.N. Au, Yuehan Gao, Tung-Chung Mou, H. van den Bedem, Qingjiong Zhang, Kaiming Zhang, Shanshan Li, Wah Chiu

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 14

Human gastric pathogen Helicobacter pylori ( H. pylori ) is the primary risk factor for gastric cancer and is one of the most prevalent carcinogenic infectious agents. Vacuolating cytotoxin A (VacA) is a key virulence factor secreted by H. pylori and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::235225f5b3f139483cfb288bdcf664c7
https://doi.org/10.1073/pnas.1821959116

Gastric Metabolomics Detects Helicobacter pylori Correlated Loss of Numerous Metabolites in Both the Corpus and Antrum

Autor: Daniela Keilberg, Nina Steele, Christina Yang, Karen M. Ottemann, Sili Fan, Yana Zavros

Publikováno v: Infection and immunity, vol 89, iss 2
Infect Immun

Helicobacter pylori is a chronic bacterial pathogen that thrives in several regions of the stomach, causing inflammation that can vary by site and result in distinct disease outcomes. Whether the regions differ in terms of host-derived metabolites is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31427b0434acc3544889eb5c5836a202
https://escholarship.org/uc/item/8381p07t