Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Digamber Rane"'
Autor:
Samir El Qaidi, Congrui Zhu, Peter McDonald, Anuradha Roy, Pradip Kumar Maity, Digamber Rane, Chamani Perera, Philip R. Hardwidge
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
The enteropathogenic and enterohemorrhagic Escherichia coli NleB proteins as well as the Salmonella enterica SseK proteins are type III secretion system effectors that function as glycosyltransferase enzymes to post-translationally modify host substr
Externí odkaz:
https://doaj.org/article/1005906719a44536a989613c520a5eae
Publikováno v:
ACS Chemical Biology. 17:1756-1768
ERAP1 and ERAP2 are endoplasmic reticulum zinc-binding aminopeptidases that play crucial roles in processing peptides for loading onto class I major histocompatibility complex proteins. These enzymes are therapeutic targets in cancer and autoimmune d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e0b9fc3a49a88cf2a3944081010c08f
https://doi.org/10.1021/acschembio.2c00093
https://doi.org/10.1021/acschembio.2c00093
Publikováno v:
ACS biomed chem Au. 2(5)
Drugs such as paclitaxel (Taxol) that bind microtubules are widely used for the treatment of cancer. Measurements of the affinity and selectivity of these compounds for their targets are largely based on studies of purified proteins, and only a few q
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::615d40e1a2051f2fc59d570cfa8fa14f
https://pubmed.ncbi.nlm.nih.gov/36281300
https://pubmed.ncbi.nlm.nih.gov/36281300
Publikováno v:
Methods in Molecular Biology ISBN: 9781071619827
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2cadf2001a895efb219127898c738c2
https://doi.org/10.1007/978-1-0716-1983-4_28
https://doi.org/10.1007/978-1-0716-1983-4_28
Publikováno v:
Methods Enzymol
Peroxynitrite (PNT) is a highly reactive oxidant that plays a key role in the destruction of foreign pathogens by specific phagocytic immune cells such as macrophages. However, when its production is dysregulated, this oxidant can contribute to cardi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7575455e04ae4c07dcee2cffcd74f64a
https://europepmc.org/articles/PMC7473247/
https://europepmc.org/articles/PMC7473247/
Autor:
Digamber Rane, Jennifer E. Golden, Richa Arya, Zachary Maben, Roger Schilling, Irini Evnouchidou, Akbar Ali, Tina T Nguyen, Marc Hickey, Samantha Bender, Efstratios Stratikos, Lawrence J. Stern, W. Frank An, Shailesh Metkar
Publikováno v:
J Med Chem
ERAP1 is an endoplasmic reticulum-resident zinc aminopeptidase that plays an important role in the immune system by trimming peptides for loading onto major histocompatibility complex (MHC-I) proteins. Here we report discovery of the first inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a62def3c1c500565a4bbc0eb9f356679
https://pubmed.ncbi.nlm.nih.gov/31841350
https://pubmed.ncbi.nlm.nih.gov/31841350
Akademický článek
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Autor:
Anuradha Roy, Peter R. McDonald, Digamber Rane, Congrui Zhu, Pradip K. Maity, Samir El Qaidi, Philip R. Hardwidge, Chamani Perera
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
Frontiers in Cellular and Infection Microbiology
Frontiers in Cellular and Infection Microbiology
The enteropathogenic and enterohemorrhagic Escherichia coli NleB proteins as well as the Salmonella enterica SseK proteins are type III secretion system effectors that function as glycosyltransferase enzymes to post-translationally modify host substr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9960120b20136ea959cd547a06de0cb1
https://www.frontiersin.org/article/10.3389/fcimb.2018.00435/full
https://www.frontiersin.org/article/10.3389/fcimb.2018.00435/full
Publikováno v:
ACS chemical biology. 13(9)
Peroxynitrite is a highly reactive oxidant derived from superoxide and nitric oxide. In normal vertebrate physiology, some phagocytes deploy this oxidant as a cytotoxin against foreign pathogens. To provide a new approach for detection of endogenous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aaf8c38d0fce39b2616a5dbae436acd
https://pubmed.ncbi.nlm.nih.gov/30141903
https://pubmed.ncbi.nlm.nih.gov/30141903
Autor:
Victor W. Day, Gurpreet Singh, James N. Plampin, Jenna L. Wang, Digamber Rane, Jeffrey Aubé, Michael C. McLeod
Publikováno v:
Nature chemistry
Screening of small-molecule libraries is an important aspect of probe and drug discovery science. Numerous authors have suggested that bioactive natural products are attractive starting points for such libraries because of their structural complexity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed9b6aa6226ce5cd7edf8cbb551f608b
https://doi.org/10.1038/nchem.1844
https://doi.org/10.1038/nchem.1844