Diffuse noxious inhibitory controls in chronic joint inflammatory Pain: Study of the descending serotonergic modulation mediated through 5HT3 receptors

Autor: Raquel Pereira-Silva, Paula Serrão, Fani Lourença Neto, Isabel Martins

Publikováno v: Neurobiology of Pain, Vol 13, Iss , Pp 100123- (2023)

The loss of diffuse noxious inhibitory controls (DNIC) is recognized as a predictor of chronic pain. Mechanistically, DNIC produces analgesia by a heterotopically applied conditioning-noxious stimulus (CS) and yet underexplored descending modulatory

Externí odkaz: https://doaj.org/article/f3ea84e216bd4170afaae2af588b760d

Developments in Understanding Diffuse Noxious Inhibitory Controls: Pharmacological Evidence from Pre-Clinical Research

Autor: Kucharczyk MW, Valiente D, Bannister K

Publikováno v: Journal of Pain Research, Vol Volume 14, Pp 1083-1095 (2021)

Mateusz Wojciech Kucharczyk,* Diego Valiente,* Kirsty Bannister Central Modulation of Pain Group, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, SE1 1UL., UK*These authors contributed equally to this workCorres

Externí odkaz: https://doaj.org/article/6548f946761d44f4b1a1c88e3e636537

Distinct brainstem to spinal cord noradrenergic pathways inversely regulate spinal neuronal activity

Autor: Mateusz W Kucharczyk, Francesca Di Domenico, Kirsty Bannister

Publikováno v: Kucharczyk, M W, Di Domenico, F & Bannister, K 2022, ' Distinct brainstem to spinal cord noradrenergic pathways inversely regulate spinal neuronal activity ', Brain, vol. 145, no. 7, pp. 2293-2300 . https://doi.org/10.1093/brain/awac085

Brainstem to spinal cord noradrenergic pathways include a locus coeruleus origin projection and diffuse noxious inhibitory controls. While both pathways are traditionally viewed as exerting an inhibitory effect on spinal neuronal activity, the locus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e199dd9cd3d8c9464d2c4ea1197ae0a2
https://doi.org/10.1093/brain/awac085

Specific alteration of rhythm in temperature-stressed rats possess features of abdominal pain in IBS patients

Autor: Yasuo Itomi, Toru Kawamura, Yasuhiro Tsukimi

Publikováno v: Journal of Pharmacological Sciences, Vol 129, Iss 1, Pp 26-30 (2015)

It is known that specific alteration of rhythm in temperature (SART) stress produces somatic pain. However, it remains to be investigated whether SART stress induces visceral pain. In this study, we investigated the visceral hypersensitivity in the S

Externí odkaz: https://doaj.org/article/746f8a9283d141f2ad21c67fee2bef06

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.