Open-channel structure of a pentameric ligand-gated ion channel reveals a mechanism of leaflet-specific phospholipid modulation.

Autor: Petroff JT 2nd; Department of Anesthesiology, Washington University School of Medicine, Saint Louis, MO, USA., Dietzen NM; Department of Anesthesiology, Washington University School of Medicine, Saint Louis, MO, USA., Santiago-McRae E; Center for Computational and Integrative Biology, Rutgers University, Camden, NJ, USA., Deng B; Department of Anesthesiology, Washington University School of Medicine, Saint Louis, MO, USA., Washington MS; Department of Anesthesiology, Washington University School of Medicine, Saint Louis, MO, USA., Chen LJ; Department of Anesthesiology, Washington University School of Medicine, Saint Louis, MO, USA., Trent Moreland K; Department of Anesthesiology, Washington University School of Medicine, Saint Louis, MO, USA., Deng Z; Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, MO, USA.; Center for the Investigation of Membrane Excitability Diseases, Washington University School of Medicine, Saint Louis, MO, USA., Rau M; Center for Cellular Imaging, Washington University School of Medicine, Saint Louis, MO, USA., Fitzpatrick JAJ; Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, MO, USA.; Center for Cellular Imaging, Washington University School of Medicine, Saint Louis, MO, USA.; Department of Neuroscience, Washington University School of Medicine, Saint Louis, MO, USA.; Department of Biomedical Engineering, Washington University School of Medicine, Saint Louis, MO, USA., Yuan P; Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, MO, USA.; Center for the Investigation of Membrane Excitability Diseases, Washington University School of Medicine, Saint Louis, MO, USA., Joseph TT; Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Hénin J; Laboratoire de Biochimie Théorique, Institut de Biologie Physico-Chimique, Université Paris Cité, CNRS UPR 9080, Paris, France., Brannigan G; Center for Computational and Integrative Biology, Rutgers University, Camden, NJ, USA.; Department of Physics, Rutgers University, Camden, NJ, USA., Cheng WWL; Department of Anesthesiology, Washington University School of Medicine, Saint Louis, MO, USA. wayland.cheng@wustl.edu.

Publikováno v: Nature communications [Nat Commun] 2022 Nov 17; Vol. 13 (1), pp. 7017. Date of Electronic Publication: 2022 Nov 17.