Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Dietmar Weitz"'
Autor:
Alexander Vugler, James O’connell, Mai Anh Nguyen, Dietmar Weitz, Thomas Leeuw, Elizabeth Hickford, Alexander Verbitsky, Xiaoyou Ying, Markus Rehberg, Bruce Carrington, Mark Merriman, Andrew Moss, Jean-Marie Nicolas, Phil Stanley, Sara Wright, Tim Bourne, Yann Foricher, Zhaoning Zhu, Daniel Brookings, Helen Horsley, Jag Heer, Laurent Schio, Matthias Herrmann, Srinivas Rao, Markus Kohlmann, Peter Florian
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/7c28a2cfd57b43f5bbbad3d413464f30
Autor:
Alexander Vugler, James O’Connell, Mai Anh Nguyen, Dietmar Weitz, Thomas Leeuw, Elizabeth Hickford, Alexander Verbitsky, Xiaoyou Ying, Markus Rehberg, Bruce Carrington, Mark Merriman, Andrew Moss, Jean-Marie Nicholas, Phil Stanley, Sara Wright, Tim Bourne, Yann Foricher, Zhaoning Zhu, Daniel Brookings, Helen Horsley, Jag Heer, Laurent Schio, Matthias Herrmann, Srinivas Rao, Markus Kohlmann, Peter Florian
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Tumor necrosis factor (TNF) is a pleiotropic cytokine belonging to a family of trimeric proteins with both proinflammatory and immunoregulatory functions. TNF is a key mediator in autoimmune diseases and during the last couple of decades several biol
Externí odkaz:
https://doaj.org/article/1ee03f08f53b498dba01c240aad2ca37
Autor:
Elisabeth Defossa, Matthias Löhn, Matthias Schäfer, Pavel Safar, Dietmar Weitz, Kristin Breitschopf, Matthias Lohmann, María Méndez, David S Thorpe, Jens Riedel, Nils Rackelmann, Hartmut Mors, Hans Matter, Michael Kurz, Ziyu Li, Michael Podeschwa, Sylvain Lebreton
Publikováno v:
Journal of Medicinal Chemistry. 63:2292-2307
The therapeutic success of peptidic GLP-1 receptor agonists for treatment of type 2 diabetes mellitus (T2DM) motivated our search for orally bioavailable small molecules that can activate the GLP-1 receptor (GLP-1R) as a well-validated target for T2D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dde87dac749897ba8532f58a4dc0ec6
https://doi.org/10.1021/acs.jmedchem.9b01071
https://doi.org/10.1021/acs.jmedchem.9b01071
Publikováno v:
Molecular Pharmaceutics. 15:3425-3433
Cimetidine decreases the renal clearance of metformin by inhibition of renal tubular cation transport, and the underlying molecular mechanisms are still not fully understood. We investigated polarized metformin transport without and with the addition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41db017ed3e34d96fd1568cda518fd13
https://doi.org/10.1021/acs.molpharmaceut.8b00416
https://doi.org/10.1021/acs.molpharmaceut.8b00416
Autor:
Diego A. Gianolio, Volker Derdau, Nicolas Philippe, George E. Duran, Jens Atzrodt, Dietmar Weitz, Jörg Blankenstein, Dorothée Semiond, Sandrine Mace, Branimir I. Sikic
Publikováno v:
Cancer Chemotherapy and Pharmacology. 81:1095-1103
The primary aim of this study was to determine cabazitaxel’s affinity for the ABCB1/P-glycoprotein (P-gp) transporter compared to first-generation taxanes. We determined the kinetics of drug accumulation and retention using [14C]-labeled taxanes in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e273176e97a4fbb732eb46918490591a
https://doi.org/10.1007/s00280-018-3572-1
https://doi.org/10.1007/s00280-018-3572-1
Autor:
Jens Atzrodt, Friedemann Schmidt, Kerstin Wäse, Jacquelyn Dwyer, Wolfgang Holla, Martina Dorau, Alexander Amberg, Volker Derdau, József Pánczél, Angela Dudda, Ulrich Kürzel, Dietmar Weitz, Elisabeth Defossa, Catherine Arabeyre, Markus Kohlmann, Timothy Ackerson, Jens Riedel, Thomas Kissner, Shibani Rajanna
Publikováno v:
Journal of Biochemical and Molecular Toxicology. 33
For fasiglifam (TAK875) and its metabolites the substance-specific mechanisms of liver toxicity were studied. Metabolism studies were run to identify a putatively reactive acyl glucuronide metabolite. In vitro cytotoxicity and caspase 3/7 activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f2228bb7b27785702d8052feb6867b
https://doi.org/10.1002/jbt.22345
https://doi.org/10.1002/jbt.22345
Autor:
Martin Sandvoss, Dietmar Weitz, Katharina Mertsch, Martin F. Fromm, Jörg König, Fabian Müller, Volker Derdau
Publikováno v:
Molecular pharmaceutics. 14(9)
The weak base memantine is actively secreted into urine, however the underlying mechanisms are insufficiently understood. Potential candidates involved in memantine renal secretion are organic cation transporter 2 (OCT2) and multidrug and toxin extru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d961844e56e6565b9aa8163b83adcd64
https://pubmed.ncbi.nlm.nih.gov/28708400
https://pubmed.ncbi.nlm.nih.gov/28708400
Autor:
Laurent Salphati, Eric Sands, Praveen Balimane, Caroline A. Lee, Johan E. Palm, Joe Bentz, Lalitha Podila, Jesse Taur, Tetsuo Yamagata, Lei K. Zhang, Kathleen M. Hillgren, Eric L. Reyner, Marie Brännström, Dietmar Weitz, Emile Plise, Jocelyn Yabut, Masoud Jamei, Harma Ellens, Anne Pak, Dallas Bednarczyk, Guangqing Xiao, Mitchell E. Taub, Libin Li, Heleen M. Wortelboer, Elke S Perloff, Andrew K Mason, Michael P. O'Connor, Krisztina Herédi-Szabó, Aarti Patel, Ganesh Rajaraman, Xiaoyan Chu, Evelyn Hollnack-Pusch, Christoph Funk, Joann Coleman, Cindy Q. Xia, Xuena Lin, Imad Hanna, Ailan Guo, Sibylle Neuhoff
Publikováno v:
Drug Metabolism and Disposition. 41:1347-1366
A P-glycoprotein (P-gp) IC₅₀ working group was established with 23 participating pharmaceutical and contract research laboratories and one academic institution to assess interlaboratory variability in P-gp IC₅₀ determinations. Each laboratory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d287357bc8fa4a0193383933cbb55d1a
https://doi.org/10.1124/dmd.112.050500
https://doi.org/10.1124/dmd.112.050500
Autor:
William Brian, Xiaomin Liang, Kathleen M. Giacomini, Dietmar Weitz, Jason M. Kinchen, Katharina Mertsch, Marilyn M. Giacomini, Deanna L. Kroetz, Srijib Goswami, Arik A. Zur, Sook Wah Yee, Annabelle Coelho, Chia Hsiang Hsueh
Publikováno v:
Clinical pharmacology and therapeutics, vol 100, iss 5
Transporter-mediated drug-drug interactions (DDIs) are a major cause of drug toxicities. Using published genome-wide association studies (GWAS) of the human metabolome, we identified 20 metabolites associated with genetic variants in organic anion tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f9411301f318dfaac43ff4b9eb346e7
https://escholarship.org/uc/item/6qx1n0sb
https://escholarship.org/uc/item/6qx1n0sb
Cyclic nucleotide-gated (CNG) channels play a central role in the conversion of sensory information, such as light and scent, into primary electrical signals. We have purified the CNG channel from bovine retina and have studied it using electron micr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad8fe42fcda70f5640278357ba3df872
https://doi.org/10.1093/emboj/21.9.2087
https://doi.org/10.1093/emboj/21.9.2087