Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Dietmar Spengler"'
Autor:
Dietmar Spengler, Theo Rein
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/b47407773400407ea583495dc9991a8d
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Despite great advances in mechanical ventilation and surfactant administration for the newborn infant with life-threatening respiratory failure no specific therapies are currently established to tackle major pro-inflammatory pathways. The susceptibil
Externí odkaz:
https://doaj.org/article/25f8b94fa8e744a5845c914fb1e4672f
Autor:
Anke Hoffmann, Dietmar Spengler
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
The nucleosome remodeling and deacetylase (NuRD) complex presents one of the major chromatin remodeling complexes in mammalian cells. Here, we discuss current evidence for NuRD’s role as an important epigenetic regulator of gene expression in neura
Externí odkaz:
https://doaj.org/article/7a69eb67f1f24f5f98b3e822f5713010
Autor:
Anke Hoffmann, Dietmar Spengler
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 12 (2018)
Mitochondria play a central role in cellular energy-generating processes and are master regulators of cell life. They provide the energy necessary to reinstate and sustain homeostasis in response to stress, and to launch energy intensive adaptation p
Externí odkaz:
https://doaj.org/article/9b4fa91fab4b40a78f13e120f71498d0
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Intraventricular hemorrhage (IVH) is a frequent major damage to the brain of premature babies ≤32 weeks gestational age, and its incidence (20–25%) has not significantly changed lately. Because of the intrinsic fragility of germinal matrix blood
Externí odkaz:
https://doaj.org/article/96cfae645994451c9284cb8ec2d6d1a9
Autor:
Anke Hoffmann, Dietmar Spengler
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 6, p 3261 (2021)
Chromodomain helicase domain 8 (CHD8) is one of the most frequently mutated and most penetrant genes in the autism spectrum disorder (ASD). Individuals with CHD8 mutations show leading symptoms of autism, macrocephaly, and facial dysmorphisms. The mo
Externí odkaz:
https://doaj.org/article/15d7a75fe86749a7b500750b8013bf58
Publikováno v:
Cells, Vol 9, Iss 2, p 366 (2020)
Genome-wide association studies (GWAS) have identified an increasing number of genetic variants that significantly associate with psychiatric disorders. Despite this wealth of information, our knowledge of which variants causally contribute to diseas
Externí odkaz:
https://doaj.org/article/9e7a49f2dd12421ea10dff3029ff87af
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 19, p 4896 (2019)
Progress in iPSC-based cellular systems provides new insights into human brain development and early neurodevelopmental deviations in psychiatric disorders. Among these, studies on schizophrenia (SCZ) take a prominent role owing to its high heritabil
Externí odkaz:
https://doaj.org/article/7ff24c43d81140e8b4461646bc35e5c9
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 12, p 3829 (2018)
Childhood-onset schizophrenia (COS) is a rare psychiatric disorder characterized by earlier onset, more severe course, and poorer outcome relative to adult-onset schizophrenia (AOS). Even though, clinical, neuroimaging, and genetic studies support th
Externí odkaz:
https://doaj.org/article/9825a0d536d04e46ac311b1e117f2f3f
Publikováno v:
Cells, Vol 7, Iss 9, p 140 (2018)
Schizophrenia (SCZ) is a devastating mental disorder that is characterized by distortions in thinking, perception, emotion, language, sense of self, and behavior. Epidemiological evidence suggests that subtle perturbations in early neurodevelopment i
Externí odkaz:
https://doaj.org/article/9684b131696c47bbbb4d08208fb4b039