Výsledky vyhledávání - "Dietmar M W Zaiss"

Akademický článek

Allergen-Specific Cytokine Polarization Protects Shetland Ponies against Culicoides obsoletus-Induced Insect Bite Hypersensitivity.

Autor: Chantal Meulenbroeks, Jaco J van der Lugt, Nathalie M A van der Meide, Ton Willemse, Victor P M G Rutten, Dietmar M W Zaiss

Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0122090 (2015)

The immunological mechanisms explaining development of an allergy in some individuals and not in others remain incompletely understood. Insect bite hypersensitivity (IBH) is a common, seasonal, IgE-mediated, pruritic skin disorder that affects consid

Externí odkaz: https://doaj.org/article/41a886b608e6422bbf5dbd01c7b17044

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Akademický článek

CCR2 defines a distinct population of NK cells and mediates their migration during influenza virus infection in mice.

Autor: Mary J G van Helden, Dietmar M W Zaiss, Alice J A M Sijts

Publikováno v: PLoS ONE, Vol 7, Iss 12, p e52027 (2012)

Natural killer (NK) cells are innate lymphocytes that play an important role in control of viral infections. We recently showed that intranasal infection of mice with influenza virus induced the accumulation of NK cells in the airways. NK cells howev

Externí odkaz: https://doaj.org/article/c513371f9dbf4a7c9c0be958a5ce1c72

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Akademický článek

Immunoproteasome-deficiency has no effects on NK cell education, but confers lymphocytes into targets for NK cells in infected wild-type mice.

Autor: Mary J G van Helden, Natascha de Graaf, Cornelis P J Bekker, Claire J P Boog, Dietmar M W Zaiss, Alice J A M Sijts

Publikováno v: PLoS ONE, Vol 6, Iss 8, p e23769 (2011)

Natural killer (NK) cells are part of the innate immune system and contribute to the eradication of virus infected cells and tumors. NK cells express inhibitory and activating receptors and their decision to kill a target cell is based on the balance

Externí odkaz: https://doaj.org/article/3533856bec0242dea463d9fad2a000f3

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Akademický článek

Loss of amphiregulin reduces myoepithelial cell coverage of mammary ducts and alters breast tumor growth

Autor: Serena P. H. Mao, Minji Park, Ramon M. Cabrera, John R. Christin, George S. Karagiannis, Maja H. Oktay, Dietmar M. W. Zaiss, Scott I. Abrams, Wenjun Guo, John S. Condeelis, Paraic A. Kenny, Jeffrey E. Segall

Publikováno v: Breast Cancer Research, Vol 20, Iss 1, Pp 1-14 (2018)

Abstract Background Amphiregulin (AREG), a ligand of the epidermal growth factor receptor, is not only essential for proper mammary ductal development, but also associated with breast cancer proliferation and growth. In the absence of AREG, mammary d

Externí odkaz: https://doaj.org/article/55ca17d6078546279abba37a1a8209dc

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Akademický článek

Emerging Role of EGFR Mutations in Creating an Immune Suppressive Tumour Microenvironment

Autor: Simran S. Kapoor, Dietmar M. W. Zaiss

Publikováno v: Biomedicines, Vol 10, Iss 1, p 52 (2021)

Several types of tumours overexpress the Epidermal Growth Factor Receptor (EGFR) in either wild type or mutated form. These tumours are often highly aggressive and difficult to treat. The underlying mechanisms for this phenomenon have remained largel

Externí odkaz: https://doaj.org/article/0514e4f3905e4dd9bda68a7568133f06

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EGFR-HIF1α signaling positively regulates the differentiation of IL-9 producing T helper cells

Autor: Suyasha Roy, Zaigham Abbas Rizvi, Anna Kathrina Simon, Amit Awasthi, Alexander J. Clarke, Dietmar M. W. Zaiss, Felicity Macdonald, Abhaydeep Pandey

Publikováno v: Roy, S, Abbas Rizvi, Z, Clarke, A J, Macdonald, F, Pandey, A, Zaiss, D M W, Simon, A K & Awasthi, A 2021, ' EGFR-HIF1α signaling positively regulates the differentiation of IL-9 producing T helper cells ', Nature Communications . https://doi.org/10.1038/s41467-021-23042-x
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

Interleukin 9 (IL-9)-producing helper T (Th9) cells are essential for inducing anti-tumor immunity and inflammation in allergic and autoimmune diseases. Although transcription factors that are essential for Th9 cell differentiation have been identifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b5c5abaecbef6d685c21241938da41
https://hdl.handle.net/20.500.11820/7a7a75bf-68e9-4324-aae6-61359ea490ac

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Local proliferation of monocytes

Autor: Stephen J. Jenkins, Dietmar M. W. Zaiss, Johanna A. Knipper

Publikováno v: Jenkins, S J, Knipper, J A & Zaiss, D M W 2020, ' Local proliferation of monocytes ', Journal of Leukocyte Biology . https://doi.org/10.1002/JLB.1CE0220-534RR

Discussion on how monocytes may contribute to the expansion of Mϕ populations at the site of inflammation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5e3c660d70e492e5cdac3882048bc61
https://doi.org/10.1002/jlb.1ce0220-534rr

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Isotype selection for antibody-based cancer therapy

Autor: Dietmar M. W. Zaiss, Andrea van Elsas, Sjef Verbeek, Natasa Vukovic

Publikováno v: Clin Exp Immunol
Vukovic, N, van Elsas, A, Verbeek, J S & Zaiss, D M W 2020, ' Isotype selection for antibody-based cancer therapy ', Clinical & Experimental Immunology, pp. 1-15 . https://doi.org/10.1111/cei.13545
Clinical & Experimental Immunology

SummaryThe clinical application of monoclonal antibodies (mAbs) has revolutionized the field of cancer therapy, as it has enabled the successful treatment of previously untreatable types of cancer. Different mechanisms play a role in the anti-tumour

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::933f27518173dff84c2e8c01ae9519c3
https://pubmed.ncbi.nlm.nih.gov/33155272

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Purification of murine immunoglobulin E (IgE) by thiophilic interaction chromatography (TIC)

Autor: Dietmar M. W. Zaiss, Salim Harraou, Andrea van Elsas, Natasa Vukovic, Sander M.J. van Duijnhoven

Publikováno v: Vukovic, N, Harraou, S, Van Duijnhoven, S M J, Zaiss, D M & Van Elsas, A 2020, ' Purification of murine immunoglobulin E (IgE) by thiophilic interaction chromatography (TIC) ', Journal of Immunological Methods . https://doi.org/10.1016/j.jim.2020.112914
Journal of Immunological Methods

In addition to their known implication in allergy studies, IgE antibodies are becoming an increasingly interesting antibody class in cancer research. However, large-scale purification of IgE antibodies still poses substantial challenges, as they cann

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7067c5fa9a66b03455bb30eaf22e7f19
https://pubmed.ncbi.nlm.nih.gov/33197470

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Amphiregulin as a driver of tissue fibrosis

Autor: Dietmar M. W. Zaiss

Publikováno v: Am J Transplant
Zaiss, D 2019, ' Amphiregulin as a driver of tissue fibrosis ', American Journal of Transplantation . https://doi.org/10.1111/ajt.15743

Chronic lung allograft dysfunction (CLAD), a condition of excess matrix deposition and airways fibrosis, limits survival after lung transplantation. Amphiregulin (Areg) is an epidermal growth factor receptor (EGFR) ligand suggested to regulate airway

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e1d06992dee6ad4aa00c91e82d0ae9
https://doi.org/10.1111/ajt.15743

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