Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Dietmar J Kappes"'
Autor:
Christoph Seiler, Nichole Gebhart, Yong Zhang, Susan A Shinton, Yue-sheng Li, Nicola L Ross, Xingjun Liu, Qin Li, Alison N Bilbee, Gaurav K Varshney, Matthew C LaFave, Shawn M Burgess, Jorune Balciuniene, Darius Balciunas, Richard R Hardy, Dietmar J Kappes, David L Wiest, Jennifer Rhodes
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0131908 (2015)
Genetic screens are a powerful tool to discover genes that are important in immune cell development and function. The evolutionarily conserved development of lymphoid cells paired with the genetic tractability of zebrafish make this a powerful model
Externí odkaz:
https://doaj.org/article/1f7bec41e2a44af78a4f88d4a9b2264a
Autor:
Jayati Basu, Jikun Zha, Emmanuelle Nicolas, Michael Coulton, Philip Czyzewicz, Xiang Hua, Lu Ge, Dietmar J. Kappes
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-18 (2022)
Basu Jayati et al. examine how T-cell receptor (TCR) engagement with MHC ligands can contribute toward adoption of CD4 and CD8 cell fates during development. By using an in vivo mutagenesis approach in mice, their results suggest potential mechanisms
Externí odkaz:
https://doaj.org/article/e2fd0822bf46482da4f29e335e8cfa99
Autor:
Billy Truong, Yong Zhang, Esteban Martinez, Brianna Trankle, Anna-Mariya Kukuyan, Susan Shinton, James Oesterling, Xiang Hua, Dietmar J Kappes, Joan Font-Burgada, Tomasz Skorski, David Wiest
Publikováno v:
Blood. 140:6733-6734
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6b86190a4d9ab3cc71221e11dc397e1
https://doi.org/10.1182/blood-2022-170264
https://doi.org/10.1182/blood-2022-170264
Autor:
Yong Zhang, Billy Truong, Shawn P Fahl, Esteban Martinez, Kathy Cai, Essel Dulaimi, Yulan Gong, Dan A. Liebermann, Jonathan Soboloff, Roland Dunbrack, Ross L. Levine, Steven Fletcher, Dietmar J. Kappes, Stephen Sykes, Paul Shapiro, David L Wiest
Publikováno v:
Blood.
While Ras/mitogen-activated protein kinase (MAPK) signaling is activated in most human cancers, attempts to target this pathway using kinase active site inhibitors have not typically led to durable, clinical benefit. To address this shortcoming, we s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3ab8dee649a03cc8d234ea9362d3d61
https://doi.org/10.1182/blood.2021013068
https://doi.org/10.1182/blood.2021013068
Autor:
Jayati Mookerjee-Basu, David E. Muench, Lisa R. Trump-Durbin, H. Leighton Grimes, Kristopher L. Nazor, Kejian Zhang, Kenneth D. Greis, Kasiani C. Myers, Baobao Song, Carolyn Lutzko, Dietmar J. Kappes, Stuart Hay, Nathan Salomonis, Giang Pham, Kyle Ferchen, Rachel A. Serafin, Sing Sing Way, Pankaj Dwivedi, Jennifer C. Yu, Somchai Chutipongtanate, Andre Olsson, Kashish Chetal
Publikováno v:
Nature
Advances in genetics and sequencing have identified a plethora of disease-associated and disease-causing genetic alterations. To determine causality between genetics and disease, accurate models for molecular dissection are required; however, the rap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0208f25c4e655f04f3b0745b74f280fb
https://doi.org/10.1038/s41586-020-2227-7
https://doi.org/10.1038/s41586-020-2227-7
Autor:
Hasan R. Kazmi, Sarah Preston-Alp, Xuan Mo, Bo Zhou, Jayati Basu, Kathy Q. Cai, M. Raza Zaidi, Dietmar J. Kappes
Publikováno v:
Oncogene
SUMMARYInterferon-gamma (IFNG) has long been regarded as the flag-bearer for the anti-cancer immunosurveillance mechanisms. However, relatively recent studies have suggested a dual role of IFNG, albeit there is no direct experimental evidence for its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a43ab650f2168eabcbd738073c8b7fa
https://doi.org/10.1101/2021.10.14.464463
https://doi.org/10.1101/2021.10.14.464463
Autor:
Christina Go, Bryant Schultz, Yi Zhang, Bo Zhou, Robert Hooper, Jonathan Ladner, Dietmar J. Kappes, Elsie Samakai, Emmanuelle Nicolas, Jonathan Soboloff, M. Raza Zaidi, Warren G. Tourtellotte, Jayati Mookerjee-Basu, Shan He, Scott Gross, Yuanyuan Tian
Publikováno v:
EMBO Rep
While the zinc finger transcription factors EGR1, EGR2, and EGR3 are recognized as critical for T‐cell function, the role of EGR4 remains unstudied. Here, we show that EGR4 is rapidly upregulated upon TCR engagement, serving as a critical “brake
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::843523d06011abd3b00d1fc308edf7cd
https://doi.org/10.15252/embr.201948904
https://doi.org/10.15252/embr.201948904
Autor:
Jayati, Basu, Bernardo S, Reis, Suraj, Peri, Jikun, Zha, Xiang, Hua, Lu, Ge, Kyle, Ferchen, Emmanuelle, Nicolas, Philip, Czyzewicz, Kathy Q, Cai, Yinfei, Tan, Juan I, Fuxman Bass, Albertha J M, Walhout, H Leighton, Grimes, Sergei I, Grivennikov, Daniel, Mucida, Dietmar J, Kappes
Publikováno v:
Nat Immunol
The transcription factor ThPOK is critical for homeostasis and differentiation of mature T helper cells. Recent studies have shown that the ThPOK transcriptional silencer element (Sil(ThPOK)) can be reactivated in mature CD4 T cell populations to rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b4e9c612aa21e94ba85a28bf2ffb29c5
https://pubmed.ncbi.nlm.nih.gov/34312548
https://pubmed.ncbi.nlm.nih.gov/34312548
Autor:
Jayati Mookerjee-Basu, Suraj Peri, Emmanuelle Nicolas, Xiang Hua, Dietmar J. Kappes, Philip Czyzewicz, Lu Ge, Dai Zhongping, Juan I FuxmanBass, Qin Li, Albertha J.M. Walhout
Publikováno v:
Molecular Biology and Evolution. 36:39-53
ThPOK is a “master regulator” of T lymphocyte lineage choice, whose presence or absence is sufficient to dictate development to the CD4 or CD8 lineages, respectively. Induction of ThPOK is transcriptionally regulated, via a lineage-specific silen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::146b4f9328e6376b58bb14c7f082c3f3
https://doi.org/10.1093/molbev/msy191
https://doi.org/10.1093/molbev/msy191
Autor:
Lisa Kain, Juan Carlos Zúñiga-Pflücker, David L. Wiest, Roland L. Dunbrack, Francis Coffey, Payam Zarin, Luc Teyton, Shawn P. Fahl, Dietmar J. Kappes
Publikováno v:
Proceedings of the National Academy of Sciences. 115:1889-1894
Unlike αβ-T lineage cells, where the role of ligand in intrathymic selection is well established, the role of ligand in the development of γδ-T cells remains controversial. Here we provide evidence for the role of a bona fide selecting ligand in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d0402393808d5429d22805191179921
https://doi.org/10.1073/pnas.1718328115
https://doi.org/10.1073/pnas.1718328115