Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Dietmar Glänzer"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 6179 (2024)
In order to overcome the resistance to radiotherapy in human chondrosarcoma cells, the prevention from efficient DNA repair with a combined treatment with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) inhibitor AZD7648 was explored fo
Externí odkaz:
https://doaj.org/article/eec46a57b1e74ba891c93b724df65dc2
Autor:
Birgit Lohberger, Dietmar Glänzer, Heike Kaltenegger, Nicole Eck, Andreas Leithner, Rudolf Bauer, Nadine Kretschmer, Bibiane Steinecker-Frohnwieser
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Background Although chondrosarcoma is the second most common primary malignant bone tumor, treatment options are limited due to its extensive resistance to a chemo- and radiation therapy. Since shikonin has shown potent anticancer activity i
Externí odkaz:
https://doaj.org/article/37b023acd5104e9f9ecbf9c0fbd5dec9
Autor:
Birgit Lohberger, Heike Kaltenegger, Nicole Eck, Dietmar Glänzer, Andreas Leithner, Nadine Kretschmer
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 21, p 15910 (2023)
Myxofibrosarcoma (MFS) is a subtype of soft tissue sarcoma of connective tissue, which is characterized by large intra-tumor heterogeneity. Therapy includes surgical resection. Additional chemotherapy is of limited effect. In this study, we demonstra
Externí odkaz:
https://doaj.org/article/b253c04473754c608e1134e4a3d29fe1
Autor:
Vanessa Etschmaier, Dietmar Glänzer, Nicole Eck, Ute Schäfer, Andreas Leithner, Dietmar Georg, Birgit Lohberger
Publikováno v:
Cells, Vol 12, Iss 18, p 2301 (2023)
Particle therapy (PT) that utilizes protons and carbon ions offers a promising way to reduce the side effects of radiation oncology, especially in pediatric patients. To investigate the influence of PT on growing bone, we exposed an organotypic rat e
Externí odkaz:
https://doaj.org/article/4a460cc946e448699b118acc4e98108f
Autor:
Birgit Lohberger, Dietmar Glänzer, Nicole Eck, Sylvia Kerschbaum-Gruber, Elisabeth Mara, Simon Deycmar, Tobias Madl, Karl Kashofer, Petra Georg, Andreas Leithner, Dietmar Georg
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Although particle therapy with protons has proven to be beneficial in the treatment of chondrosarcoma compared to photon-based (X-ray) radiation therapy, the cellular and molecular mechanisms have not yet been sufficiently investigated. Cell
Externí odkaz:
https://doaj.org/article/c249fa5290854629a486e51aa2fe0509
Autor:
Birgit Lohberger, Dietmar Glänzer, Nicole Eck, Katharina Stasny, Anna Falkner, Andreas Leithner, Dietmar Georg
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2315 (2023)
To overcome the resistance to radiotherapy in chondrosarcomas, the prevention of efficient DNA repair with an additional treatment was explored for particle beams as well as reference X-ray irradiation. The combined treatment with DNA repair inhibito
Externí odkaz:
https://doaj.org/article/a054ea5fcdea4373b3dacb3c744d59f0
Autor:
Birgit Lohberger, Sandra Barna, Dietmar Glänzer, Nicole Eck, Sylvia Kerschbaum-Gruber, Katharina Stasny, Andreas Leithner, Dietmar Georg
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11464 (2022)
Chondrosarcomas are particularly difficult to treat due to their resistance to chemotherapy and radiotherapy. However, particle therapy can enhance local control and patient survival rates. To improve our understanding of the basic cellular radiation
Externí odkaz:
https://doaj.org/article/49cd8d052b044a9597a021c4a1143424
Autor:
Birgit Lohberger, Heike Kaltenegger, Nicole Eck, Dietmar Glänzer, Patrick Sadoghi, Andreas Leithner, Rudolf Bauer, Nadine Kretschmer, Bibiane Steinecker-Frohnwieser
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 6, p 3396 (2022)
Osteoarthritis (OA) is the most common joint disorder and is characterized by the degeneration of articular cartilage. To develop new therapeutic approaches, we investigated the effect of shikonin derivatives on inflammation, MMP expression, and the
Externí odkaz:
https://doaj.org/article/0da2f18d8ae04186a42a6889109b9b19
Autor:
Paul Schadler, Martin H Stradner, Nicole Stündl, Birgit Lohberger, Dietmar Glänzer, Patrick Sadoghi, Andreas Leithner, Bibiane Steinecker-Frohnwieser
Publikováno v:
Cartilage
Objective Obesity is a known risk factor for knee osteoarthritis (OA). Diabetes has been associated with progression of OA and metformin is the first-line treatment in type 2 diabetes. The effect of the body mass index (BMI) and metformin on the expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce451123398abc1417ff8640cdd5c88f
https://doi.org/10.1177/1947603520962558
https://doi.org/10.1177/1947603520962558
Publikováno v:
Zeitschrift für Orthopädie und Unfallchirurgie.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a575e5f318e2f11e8574bf1166e5659
https://doi.org/10.1055/s-0040-1717494
https://doi.org/10.1055/s-0040-1717494