Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Dietmar, Zechner"'
Autor:
Tim Schreiber, Ingo Koopmann, Jakob Brandstetter, Steven R. Talbot, Lea Goldstein, Lisa Hoffmann, Anna Schildt, Markus Joksch, Bernd Krause, Robert Jaster, Rupert Palme, Dietmar Zechner, Brigitte Vollmar, Simone Kumstel
Publikováno v:
Biomedicines, Vol 12, Iss 7, p 1494 (2024)
Animal models are crucial to preclinical oncological research and drug development. Animal experiments must be performed in accordance with the 3R principles of replacement and reduction, if possible, and refinement where these procedures remain cruc
Externí odkaz:
https://doaj.org/article/4c9b8db04af94f29a2bbb907d2af0e71
Autor:
Guanglin Tang, Wiebke-Felicitas Nierath, Emily Leitner, Wentao Xie, Denis Revskij, Nico Seume, Xianbin Zhang, Luise Ehlers, Brigitte Vollmar, Dietmar Zechner
Publikováno v:
PLoS ONE, Vol 19, Iss 7, p e0303786 (2024)
A prevailing animal model currently used to study severe human diseases like obstructive cholestasis, primary biliary or sclerosing cholangitis, biliary atresia, and acute liver injury is the common bile duct ligation (cBDL). Modifications of this mo
Externí odkaz:
https://doaj.org/article/06f6206bc8b14322a0e9d13f7e81c845
Autor:
Steven R. Talbot, Simone Kumstel, Benjamin Schulz, Guanglin Tang, Ahmed Abdelrahman, Nico Seume, Edgar H. U. Wendt, Johanna Eichberg, Christine Häger, André Bleich, Brigitte Vollmar, Dietmar Zechner
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract The fundament of an evidence-based severity assessment in laboratory animal science is reliable distress parameters. Many readouts are used to evaluate and determine animal distress and the severity of experimental procedures. Therefore, we
Externí odkaz:
https://doaj.org/article/59b5dab59e6e456a83548cc162f6ed59
Autor:
Wentao Xie, Matthias Lorenz, Friederike Poosch, Rupert Palme, Dietmar Zechner, Brigitte Vollmar, Eberhard Grambow, Daniel Strüder
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract The dorsal skinfold chamber is one of the most important in vivo models for repetitive longitudinal assessment of microcirculation and inflammation. This study aimed to refine this model by introducing a new lightweight chamber made from pol
Externí odkaz:
https://doaj.org/article/7c9948c2d6c2470797f5feba7063d7cc
Autor:
Lucas Mösch, Janosch Kunczik, Lukas Breuer, Dorit Merhof, Peter Gass, Heidrun Potschka, Dietmar Zechner, Brigitte Vollmar, René Tolba, Christine Häger, André Bleich, Michael Czaplik, Carina Barbosa Pereira
Publikováno v:
PLoS ONE, Vol 18, Iss 9, p e0286230 (2023)
This study presents a novel concept for a smart home cage design, tools, and software used to monitor the physiological parameters of mice and rats in animal-based experiments. The proposed system focuses on monitoring key clinical parameters, includ
Externí odkaz:
https://doaj.org/article/cf27ac11a6d04ccba17afde45c885a2c
Autor:
Simone Kumstel, Praveen Vasudevan, Rupert Palme, Xianbin Zhang, Edgar Heinz Uwe Wendt, Robert David, Brigitte Vollmar, Dietmar Zechner
Publikováno v:
Journal of Advanced Research, Vol 21, Iss , Pp 35-47 (2020)
Prospective severity assessment is legally required in many countries to ensure high-quality research along with high welfare standards for laboratory animals. Mice and rats, the most common laboratory species, are prey animals that usually suppress
Externí odkaz:
https://doaj.org/article/26edb334e1344567b7979cf5ed6af03b
Autor:
Simone Kumstel, Tim Schreiber, Lea Goldstein, Jan Stenzel, Tobias Lindner, Markus Joksch, Xianbin Zhang, Edgar Heinz Uwe Wendt, Maria Schönrogge, Bernd Krause, Brigitte Vollmar, Dietmar Zechner
Publikováno v:
PLoS ONE, Vol 17, Iss 4, p e0266601 (2022)
Pancreatic cancer is the fourth leading cause of cancer death, with a 5-year survival rate of 10%. A stagnant high mortality rate over the last decades highlights the need for innovative therapeutic approaches. Pancreatic tumors pursue an altered met
Externí odkaz:
https://doaj.org/article/dd2a203bb1614ff2a19d323403d62670
Analysis of Pain and Analgesia Protocols in Acute Cerulein-Induced Pancreatitis in Male C57BL/6 Mice
Autor:
Mattea Durst, Theresia Reding Graf, Rolf Graf, Mareike Kron, Margarete Arras, Dietmar Zechner, Rupert Palme, Steven R. Talbot, Paulin Jirkof
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Pancreatitis is known to be painful in humans and companion animals. However, the extent of pain in experimental mouse models of acute pancreatitis is unknown. Consequently, the severity classification of acute pancreatitis in mice is controversially
Externí odkaz:
https://doaj.org/article/d6f4ca10b124429e90c5ca8998d56365
Autor:
Dietmar Zechner, Benjamin Schulz, Guanglin Tang, Ahmed Abdelrahman, Simone Kumstel, Nico Seume, Rupert Palme, Brigitte Vollmar
Publikováno v:
Animals, Vol 12, Iss 21, p 2927 (2022)
An essential basis for objectively improving the status of animals during in vivo research is the ability to measure the wellbeing of animals in a reliable and scientific manner. Several non-invasive methods such as assessing body weight, burrowing a
Externí odkaz:
https://doaj.org/article/93d96c2cc4134f0f907e22b53f3062bf
Autor:
Xianbin Zhang, Simone Kumstel, Ke Jiang, Songshu Meng, Peng Gong, Brigitte Vollmar, Dietmar Zechner
Publikováno v:
Journal of Advanced Research, Vol 20, Iss , Pp 9-21 (2019)
The efficacy of gemcitabine therapy is often insufficient for the treatment of pancreatic cancer. The current study demonstrated that LW6, a chemical inhibitor of hypoxia-inducible factor 1α, is a promising drug for enhancing the chemosensitivity to
Externí odkaz:
https://doaj.org/article/09ef178c450a429a844ced81de6aa3d9