Výsledky vyhledávání - "Dietmar, Weilguny"

Akademický článek

RUBY® – a tetravalent (2+2) bispecific antibody format with excellent functionality and IgG-like stability, pharmacology and developability properties

Autor: Barnabas Nyesiga, Mattias Levin, Anna Säll, Anna Rosén, Kim Jansson, Sara Fritzell, Karin Hägerbrand, Dietmar Weilguny, Laura von Schantz

Publikováno v: mAbs, Vol 16, Iss 1 (2024)

ABSTRACTDespite the large number of existing bispecific antibody (bsAb) formats, the generation of novel bsAbs is still associated with development and bioprocessing challenges. Here, we present RUBY, a novel bispecific antibody format that allows ra

Externí odkaz: https://doaj.org/article/3554ed116f6c45079b118217d1d8fd6f

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Akademický článek

Defining lncRNAs Correlated with CHO Cell Growth and IgG Productivity by RNA-Seq

Autor: Davide Vito, Jens Christian Eriksen, Christian Skjødt, Dietmar Weilguny, Søren K. Rasmussen, C. Mark Smales

Publikováno v: iScience, Vol 23, Iss 1, Pp - (2020)

Summary: How the long non-coding RNA (lncRNA) genome in recombinant protein producing Chinese hamster ovary (CHO) cell lines relates to phenotype is not well described. We therefore defined the CHO cell lncRNA transcriptome from cells grown in contro

Externí odkaz: https://doaj.org/article/715ccdf3618c421e9f5254716f80e698

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Supplementary Figures S1-8 from Pan-HER, an Antibody Mixture Simultaneously Targeting EGFR, HER2, and HER3, Effectively Overcomes Tumor Heterogeneity and Plasticity

Autor: Johan Lantto, Michael Kragh, Mikkel W. Pedersen, Ivan D. Horak, Christina R. Andersen, Bolette Bjerregaard, Dietmar Weilguny, Jette W. Sen, Klaus Koefoed, Ida Kjær, Anna Dahlman, Thomas T. Poulsen, Helle J. Jacobsen

Supplementary Figures S1-8. Figure S1 - Analysis of nonlinear blending synergy for the pairs of antibodies that constitute Pan-HER. Figure S2 - In vitro comparison of Pan-HER and a combination of cetuximab, trastuzumab and MM-121. Figure S3 - In vivo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3070cce3b363e6339b7b3ea62fc19ee0
https://doi.org/10.1158/1078-0432.22457522.v1

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Supplementary Methods from Pan-HER, an Antibody Mixture Simultaneously Targeting EGFR, HER2, and HER3, Effectively Overcomes Tumor Heterogeneity and Plasticity

Supplementary Methods. Description of methods used for assessment of synergy, immunohistochemistry, cell death, cell cycle arrest, ADCC and CDC.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::613b15db10e954d8709624ee366dd4b8
https://doi.org/10.1158/1078-0432.22457519.v1

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Supplementary Tables S1-2 from Pan-HER, an Antibody Mixture Simultaneously Targeting EGFR, HER2, and HER3, Effectively Overcomes Tumor Heterogeneity and Plasticity

Supplementary Tables S1-2. Table S1 - Source, origin, subtype and growth medium for each cell line. Table S2 - Characteristics of tested patient-derived xenograft models.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375612fd610b86cb208abe84d726cc97
https://doi.org/10.1158/1078-0432.22457516.v1

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Data from Pan-HER, an Antibody Mixture Simultaneously Targeting EGFR, HER2, and HER3, Effectively Overcomes Tumor Heterogeneity and Plasticity

Purpose: Accumulating evidence indicates a high degree of plasticity and compensatory signaling within the human epidermal growth factor receptor (HER) family, leading to resistance upon therapeutic intervention with HER family members.Experimental D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33475f6437c82fd198f9e199000933c9
https://doi.org/10.1158/1078-0432.c.6523604

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Defining lncRNAs Correlated with CHO Cell Growth and IgG Productivity by RNA-Seq

Autor: Søren Kofoed Rasmussen, Davide Vito, Jens Christian Eriksen, Dietmar Weilguny, C. Mark Smales, Christian Skjødt

Publikováno v: iScience
iScience, Vol 23, Iss 1, Pp-(2020)

Summary How the long non-coding RNA (lncRNA) genome in recombinant protein producing Chinese hamster ovary (CHO) cell lines relates to phenotype is not well described. We therefore defined the CHO cell lncRNA transcriptome from cells grown in control

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3cb2db8b391db39833188dde2b527d3

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A multi-pronged investigation into the effect of glucose starvation and culture duration on fed-batch CHO cell culture

Autor: Dietmar Weilguny, Christian Müller, Anne Mathilde Lund, Jette Wagtberg Sen, Cleo Kontoravdi, Søren Kofoed Rasmussen, Yuzhou Fan, Ioscani Jimenez del Val, Michael J. Betenbaugh, Mikael Rørdam Andersen, Deniz Baycin-Hizal

Publikováno v: Biotechnology and Bioengineering. 112:2172-2184

In this study, omics-based analysis tools were used to explore the effect of glucose starvation and culture duration on monoclonal antibody (mAb) production in fed-batch CHO cell culture to gain better insight into how these parameters can be control

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf3ff5f631ee5d6f7a7ba698974c7826
https://doi.org/10.1002/bit.25620

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Amino acid and glucose metabolism in fed-batch CHO cell culture affects antibody production and glycosylation

Autor: Ioscani Jimenez del Val, Cleo Kontoravdi, Jette Wagtberg Sen, Søren Kofoed Rasmussen, Yuzhou Fan, Dietmar Weilguny, Christian Müller, Mikael Rørdam Andersen

Publikováno v: Biotechnology and Bioengineering. 112:521-535

Fed-batch Chinese hamster ovary (CHO) cell culture is the most commonly used process for IgG production in the biopharmaceutical industry. Amino acid and glucose consumption, cell growth, metabolism, antibody titer, and N-glycosylation patterns are a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8820f132a264570fd70977e278d3f2db
https://doi.org/10.1002/bit.25450

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Toward genome-scale models of the Chinese hamster ovary cells: incentives, status and perspectives

Autor: Mikael Rørdam Andersen, Claus Kristensen, Helene Faustrup Kildegaard, Christian Schrøder Kaas, Dietmar Weilguny, Yuzhou Fan

Publikováno v: Pharmaceutical Bioprocessing. 2:437-448

Bioprocessing of the important Chinese hamster ovary (CHO) cell lines used for the production of biopharmaceuticals stands at the brink of several redefining events. In 2011, the field entered the genomics era, which has accelerated omics-based pheno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0cbc9d7fd7387359be40df907e1020e6
https://doi.org/10.4155/pbp.14.54

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