Implant for Augmentation of Cerebral Blood Flow Trial-1 (ImpACT-1). A single-arm feasibility study evaluating the safety and potential benefit of the Ischemic Stroke System for treatment of acute ischemic stroke.

Autor: Dheeraj Khurana, Subhash Kaul, Dietmar Schneider, Attila Csanyi, Ilona Adam, Nasli R Ichaporia, Bernd Griewing, Laszlo Csiba, Attila Valikovics, Vinod Puri, Hans Christoph Diener, Stefan Schwab, Andreas Hetzel, Natan Bornstein, ImpACT-1 Study Group

Publikováno v: PLoS ONE, Vol 14, Iss 7, p e0217472 (2019)

BACKGROUND:The Ischemic Stroke System is a novel device designed to deliver stimulation to the sphenopalatine ganglion(SPG).The SPG sends parasympathetic innervations to the anterior cerebral circulation. In rat stroke models, SPG stimulation results

Externí odkaz: https://doaj.org/article/1ee5ece7b6814459b76a4e7b56c2215a

Sphenopalatine Ganglion Stimulation to Augment Cerebral Blood Flow

Autor: Natan M. Bornstein, Jeffrey L. Saver, Hans-Christoph Diener, Philip B. Gorelick, Ashfaq Shuaib, Yoram Solberg, Thomas Devlin, Thomas Leung, Carlos A. Molina, David Skoloudik, Jan Fiksa, Derk Krieger, Grethe Andersen, Joerg Berrouschot, Carsten Hobohm, Dietmar Schneider, Bernd Griewing, Matthias Endres, Karl-Georg Hausler, Hubert Kimmig, Peter Ringleb, Christian Weimar, Matthias Schilling, Martin Kohrmann, Andreas Hetzel, Manfred Kaps, Raymond Cheung, Piotr Sobolewski, Walenty Nyke, Anna Czlonkowska, Adam Stepien, Brola Waldemar, Agnieszka Słowik, Stelmasiakiem Zbigniewem, Ignacy Lubiński, Pedro Portela, Tomas Segure, Joan Marti-Fabregas, Maria Alonso, Antonio Nunez, Miguel Blanco Miguel, Anna Campello, Joaquin Arenillas, Nash Marshall, David Chiu, Harish Shownkeen, Marilyn Rymer, Souvik Sen, Martin Roubec, Martin Kuliha, Ctirad Lakomý, David Tyl, David Kemlink, Ondřej Doležal, Petra Rekova, Veronika Krejčí, Anders Christensen, Bo Belhage, Christian Maschmann, Christian Kruse Larsen, Frank Pott, Hanne Christensen, Jakob Marstrand, Jens Kjellberg Nielsen, Per Meden, Svend Prytz, Sverre Rosenbaum, Jens Christian Hedemann Sorensen, Kaare Stenhoj Meier, Kare Schmift Ettrup, Kristina Dupont Hougaard, Paul Von Wietzel, Anett Stoll, Hans Schwetlick, Hendirk Pradel, Alexander Hemprich, Andreas Schulz, Bernhard Frerich, Christopher Weise, Dominik Michalski, Felix Schaller, Franziska Schiefke, Jens Helmrich, Johann Pelz, Martin Schnieder, Martin Schneider, Peter Matzen, Rudiger Langos, Stephan Müller-Duerwald, Sven Lukhaup, Ute Bauer, Wolfgang Kloppig, Erich Hiermann, Gregor Mucha, Hassan Soda, Renate Weinhardt, Teresa Mucha, Volker Ziegler, Alexander Abbushi, Benjamin Hotter, Benjamin Winter, Birgit Anthofer, Cornelia Noack, Dinah Laubisch, Gerd Heldge Schneider, Gerhard Jan Jungehulsing, Heiko Mueller, Jens Dreier, Jochen Fiebach, Julia Flechsenhar, Kersten Villringer, Martin Ebinger, Michael Rozanski, Peter Vajkoczy, Randolf Klingebiel, Robert Steinicke, Sandra Pittl, Sarah Hoffmann, Stephan Maul, Thomas Krause, Thomas Liman, Thomas Plath, Tim Nowe, Wolf Schmidt, Carsten Fritzsch, Christopher Haas, Hans-Gerd Will, Katja Haußmann-Betz, Mohsen Bayat, Tomazs Pordzik, Andreas Hug, Christian Jürgen Staff, Christoph Lichy, Georg Eggers, Manja Kloss, Martin Bendszus, Oliver Herrmann, Robin Seeberger, Soenke Schwarting, Stefan Rhode, Timolaos Rizos, Werner Hacke, Benedikt Frank, Bessi Bozkurt, Dagny Holle, Daniel Mueller, Dirk Koch, Hind Shanib, Joachim Sudendey, Johannes Brenck, Kolja Busch, Kristina Gartzen, Thomas Gasser, Tim Hagenacker, Boris Buerke, Gudrun Prigge, Jens Minnerup, Johannes Albers, Kai Wermker, Wolfram Schwindt, Ringlestein, Bernd Kallmünzer, Eva Hauer, Lorenz Breuer, Peter Schellinger, Rainer Kollmar, Roland Sauer, Stefan Schwab, Tobias Struffert, Anette Funfack, Anne Stechmann, Axel Schlaeger, Claus Laeppchen, Florian Schuchardt, Jan-Helge Klingler, Janine Reis, Johann Lambeck, Mirko Friedrich, Mona Laible, Philip Wellermeyer, Sandra Beck, Sebastian Rutsch, Wolf-Dirk Niesen, Christian Tanislav, Heidrun Schaaf, Heiko Kerkmann, Ingo Schirotzek, Jens Allendörfer, Stephanie Wolff, Alexander Yuk-Lun Lau, Anne Yin Yan Chan, Deyond Siu, Edward HC Wong, George Kwok Chu Wong, Howan Leung, Lawrence K.S. Wong, Xian Lun Zhu, Yannie Oi Yan Soo, Alan Choi Ting Tse, Gilberto Ka Kit Leung, Kar Ming Leung, Kwan Ngai Hung, May Wai Mei Kwan, Mona Man Yu Tse, Philip Tse, Ping Hon Chan, Raymand Lee, Richard Shek Kwan Chang, Shirley Yin Yu Pang, Sonny Fong Kwong Hon, Tat Sun Cheng, Wai Man Lui, Windsor Wai Wo Mak, Anna Sobota, Baeta Wiater, Barbara Loch, Genowefa Wolak, Irena Łabudzka, Jan Dabal, Marcin Grzesik, Monika Sledzinska, Renata Hatalska-Żerebiec, Wiktor Szczuchniak, Anna Gójska, Dariusz Nałęcz, Dariusz Gasecki, Grzegorz Kozera, Łukasz Dylewicz, Marcin Niekra, Mariusz Kwarciany, Piotr Chomik, Piotr Skowron, Adam Kobayashi, Grzegorz Chabik, Grzegorz Makowicz, Jan Bembenek, Julia Jędrzejewska, Michal Karlinski, Wojciech Czepiel, Bogdan Brodacki, Jacek Staszewski, Jarosław Kosek, Marcin Jadczak, Marta Durka-Kęsy, Krzysztof Kaluzny, Małgorzata Ziomek, Małgorzata Fudala, Zbigniew Sosnowski, Antoni Ferens, Elżbieta Szczygieł, Krzysztof Banaszkiewicz, Maciej Ziomek, Marcin Wnuk, Anna Szczepańska-Szerej, Ewa Jach, Grazyna Elzbieta Maslanko, Joanna Wojczal, Piotr Luchowski, Andrzej Kowalczyk, Jerzy Jakubiak, Joanna Kopcewicz, Maciej Gajda, Malgorzata Wichlinska-Lubinska, David Rodriguez, Estevo Santamarin, Jorge Pagola, Juan Lorente Guerrero, Marc Ribo, Marta Rubiera, Olga Maisterra, Soccoro Pinero, Valera Catalina Iglesias, Gerard Plans, Helena Quesada, Marco Alberto Aparicio Caballero, Pedro Cardona Portela, Antonio Belinchon De Diego, David Sopelana Garay, Máximo Rafael García Rodriguez, Oscar Ayo Martin, Silvia Crusat Braña, Jorge Garcia, Fernando Munoz Hernandez, Ignasi Catala, Josep Lluis Marti-Vilalta, Rachel Delgado Mederos, Schmid Cristian de Quintana, Sergi Martinez-Ramirez, Jaime Valcarcel Gonzalez, Jaime Masjuan Vallejo, Jorge Diamantopoulus, Marta Del Alamo, Pedro Domingo Poveda, Andres Garcia Pastor, Calros Fernandez Carballal, Fernando Diaz, Roberto Garcia Leal, Ruiz Juretschke, Eduardo Arán Echabe, Jose Castillo Sanchez, Manuel Rodriguez Yanez, Ramon Serramito Garcia, Rogelio Leira Muino, Susana Arias Rivas, Demian Manzano Lopez Gonzalez, Elisa Cuadrado, Eva Giralt, Gloria Villalba, Jaime Roquer, Ois Angel, Maria Jimenez, René Robles Cedeño, Ruy Salinas, Saioa Lejarreta, Yolanda Silva, Adela Fraile, Ana Calleja, Guillermo Arturo Cepeda Landínez, Nieves Tellez, Pablo Garcia Bermejo, Pérez Jaime Santos, Rosa Fernandez Herranz, Peter Hunt, Donald Browning, Michael Violette, Robert Hoddeson, James Rose, Jonathan Zhang, Avi Mazumdar, Henri Echiverri, James Chow, Darren Lovick, Martin Coleman, Naveed Akhtar, Rebecca Sugg, Adam Zanation, Anand Germanwala, Brent Senior, David Huang, Natalie Aucutt-Walter, Scott Kasner, Peter LeRoux, Rüdiger von Kummer, Yuko Palesch

Publikováno v: Stroke. 50:2108-2117

Background and Purpose— Many patients with acute ischemic stroke are not eligible for thrombolysis or mechanical reperfusion therapies due to contraindications, inaccessible vascular occlusions, late presentation, or large infarct core. Sphenopalat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d6f2bde818a0b44d30df86d67133628
https://doi.org/10.1161/strokeaha.118.024582

An injectable implant to stimulate the sphenopalatine ganglion for treatment of acute ischaemic stroke up to 24 h from onset (ImpACT-24B): an international, randomised, double-blind, sham-controlled, pivotal trial

Autor: Natan M Bornstein, Jeffrey L Saver, Hans Christoph Diener, Philip B Gorelick, Ashfaq Shuaib, Yoram Solberg, Lisa Thackeray, Milan Savic, Tamar Janelidze, Natia Zarqua, David Yarnitsky, Carlos A Molina, Michael Hill, Daniel Vaclavik, David Skoloudik, Jan Fiksa, Grethe Andersen, Pekka Jakala, Turgut Tatlisumak, Igor Kuzmanovski, Benoit Guillon, Hugues Chabriat, Marie Helene Mahagne, Serge Timsit, Thomas Ronziere, Gocha Ingorokva, Maya Beridze, Mzia Beridze, Nino Kharaishvili, Nodar Kakabadze, Bernd Griewing, Carsten Hobohm, Dietmar Schneider, Christian Weimar, Holger Poppert, Hubert Kimmig, Joerg Berrouschot, Peter Ringleb, Stefan Schwab, Martin Kohrmann, Bernd Kallmunzer, Rainer Kollmar, Matthias Endres, Karl-Georg Hausler, Raymond Cheung, Thomas Wai Hong Leung, Elena Dorodnicov, Hen Halevi, Eitan Auriel, Jonathan Streifler, Ronen Leker, Yvonne Schwammenthal, Danilo Toni, Giancarlo Agnelli, Valeria Caso, Agnieszka Słowik, Anna Czlonkowska, Ignacy Lubinski, Jan Kochanowicz, Piotr Sobolewski, Waldemar Brola, Antonio Vasco Salgado, Carlos Correia, Elsa Azevedo, Jose Roriz, Marija Zarkov, Zarko Petrovic, Georgi Krastev, Miloslav Dvorak, Ana Rodriguez Campello, Antonio Gil Nunez, Carlos Molina, Francisco Purroy, Joan Marti-Fabregas, Juan Arenillas, Maria Alonso, Pedro Cardona, Miguel Blanco Gonzalez, Silvia Tur, Tomas Segura Martin, Payenok Anzhelika, Harish Shownkeen, Mauricio Concha, Pramod Sethi, Souvik Sen, Syed Zaidi, Thomas Devlin

Publikováno v: Lancet (London, England). 394(10194)

Sphenopalatine ganglion stimulation increased cerebral collateral blood flow, stabilised the blood-brain barrier, and reduced infarct size, in preclinical models of acute ischaemic stroke, and showed potential benefit in a pilot randomised trial in h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e45783f3afe74347a6106c9e2874e5b8
https://pubmed.ncbi.nlm.nih.gov/31327352

Transcranial Laser Therapy in Acute Stroke Treatment

Autor: Reid Taylor, Natan M. Bornstein, Margaret Tremwel, Bo Norrving, Anastasia Ivanova, Andreas R. Luft, Roland Veltkamp, Tomás Segura, Dietmar Schneider, Carlos A. Molina, Thomas Haarmeiter, Martin Grond, Franz Gruber, Gerhard Hamman, Helmuth Steinmetz, Thomas Devlin, Didier Leys, Rachael L. Fulton, Steven P. Richieri, Werner Hacke, Patrik Michel, Julio Perez, Björn Dahlöf, Justin A. Zivin, Patrick Capone, Stephen G. Dilly, Marshall Nash, George Howell, Philippe Lyrer, Lennart Welin, Joseph P. Broderick, Martin Köhrmann, Karen C. Johnston, Marilyn M. Rymer, Jack Cochran, Greg Albars, Scott E. Kasner, Majaz Moonis, Christian Weimar, Thorsten Steiner, Brian Buck, Martin A. Ritter, David M. Brown, Colin Deredyn, Björn Andersson, Shazam Hussain, Kennedy R. Lees, Ashfaq Shuaib, Peter Schallinger, Jan Sobesky, Sidney Mallenbaum, Peter D. Schellinger, Andrei V. Alexandrov, Christian Gerloff, Sebastian Jander, William Hickling, Bernd Greiwing, David Chiu, David Y. Huang, Wayne M. Clark, Gregory W. Albers, Turgut Tatlisumak

Publikováno v: Stroke. 45:3187-3193

Background and Purpose— On the basis of phase II trials, we considered that transcranial laser therapy could have neuroprotective effects in patients with acute ischemic stroke. Methods— We studied transcranial laser therapy in a double-blind, sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8845547f7c3dd634ac61f24afd02b8a
https://doi.org/10.1161/strokeaha.114.005795

Organ-Protective Intensive Care in Organ Donors

Autor: Klaus Böhler, Heiner Wolters, Klaus Hahnenkamp, Hartmut Schmidt, Dietmar Schneider, Karsten Wiebe

Background The ascertainment of brain death (the irreversible, total loss of brain function) gives the physician the opportunity to limit or stop further treatment. Alternatively, if the brain-dead individual is an organ donor, the mode of treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60fbad19c22825cd64e3bc58b910e66b
https://europepmc.org/articles/PMC5015577/