Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Dietmar, Gradl"'
Autor:
Laetitia Préau, Anna Lischke, Melanie Merkel, Neslihan Oegel, Maria Weissenbruch, Andria Michael, Hongryeol Park, Dietmar Gradl, Christian Kupatt, Ferdinand le Noble
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Formation of organo-typical vascular networks requires cross-talk between differentiating parenchymal cells and developing blood vessels. Here we identify a Vegfa driven venous sprouting process involving parenchymal to vein cross-talk regul
Externí odkaz:
https://doaj.org/article/fa5c6f3f772649d6a39c8746299ff9de
Autor:
Katharina Puzik, Veronika Tonnier, Isabell Opper, Antonia Eckert, Lu Zhou, Marie-Claire Kratzer, Ferdinand le Noble, Gerd Ulrich Nienhaus, Dietmar Gradl
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Abstract The activation of distinct branches of the Wnt signaling network is essential for regulating early vertebrate development. Activation of the canonical Wnt/β-catenin pathway stimulates expression of β-catenin-Lef/Tcf regulated Wnt target ge
Externí odkaz:
https://doaj.org/article/5d0d6020b0a44fca92dd365bddb89771
Autor:
Vladimir Korinek, Petr Bartunek, Zbynek Zdrahal, Jindrich Jindrich, Olga Machonova, Vitezslav Kriz, Monika Horazna, Eva Sloncova, Michaela Krausova, Dietmar Gradl, Jitka Stancikova, Martina Vojtechova, Antonio R. Pombinho, Lucie Tumova
The Wnt signaling pathway is required during embryonic development and for the maintenance of homeostasis in adult tissues. However, aberrant activation of the pathway is implicated in a number of human disorders, including cancer of the gastrointest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0b5ad80d390450cfcc66779c4db350e
https://doi.org/10.1158/1535-7163.c.6536254
https://doi.org/10.1158/1535-7163.c.6536254
Autor:
Vladimir Korinek, Petr Bartunek, Zbynek Zdrahal, Jindrich Jindrich, Olga Machonova, Vitezslav Kriz, Monika Horazna, Eva Sloncova, Michaela Krausova, Dietmar Gradl, Jitka Stancikova, Martina Vojtechova, Antonio R. Pombinho, Lucie Tumova
PDF file - 515KB, Supplementary Materials and Methods. Supplementary Figure S1. Densitometric analysis of western blots shown in Figs. 2D (A), 3C (B) and 4D (C). Supplementary Figure S2. Monensin suppresses Wnt signaling activated by TALEN-induced di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8711be6e574a82a73568181fdd1f47d
https://doi.org/10.1158/1535-7163.22499776.v1
https://doi.org/10.1158/1535-7163.22499776.v1
Autor:
Stefan Krauss, Jens Peter von Kries, Andrey Voronkov, Dietmar Gradl, Olga Machonova, Tor J. Eide, Nina Marie Pedersen, Jan Erik Paulsen, Steven Ray Wilson, Vladimir Korinek, Huyen Dinh, Lucie Tumova, Ondrej Machon, Jo Waaler
PDF file - 160K, Determination of IC50-values in HEK293 cells (ST-Luc) and biochemical assays (TNKS1/2 and PARP) using XLfit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc5deca1e98540c21689b9cf71c18c56
https://doi.org/10.1158/0008-5472.22391892.v1
https://doi.org/10.1158/0008-5472.22391892.v1
Autor:
Stefan Krauss, Jens Peter von Kries, Andrey Voronkov, Dietmar Gradl, Olga Machonova, Tor J. Eide, Nina Marie Pedersen, Jan Erik Paulsen, Steven Ray Wilson, Vladimir Korinek, Huyen Dinh, Lucie Tumova, Ondrej Machon, Jo Waaler
PDF file - 65K, The distribution and steady-state level of b-catenin as visualized by immunofluorescence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dcdf1d164cb27a876055486f7ac655d
https://doi.org/10.1158/0008-5472.22391886.v1
https://doi.org/10.1158/0008-5472.22391886.v1
Autor:
Stefan Krauss, Jens Peter von Kries, Andrey Voronkov, Dietmar Gradl, Olga Machonova, Tor J. Eide, Nina Marie Pedersen, Jan Erik Paulsen, Steven Ray Wilson, Vladimir Korinek, Huyen Dinh, Lucie Tumova, Ondrej Machon, Jo Waaler
PDF file - Human liver microsome (HLM) test of JW55 (A), weight measurement of ApcCKO/CKOLgr5-CreERT2+ mice treated with JW55 or vehicle (B) and an example on quantification of tumor number and area using Ellipse software (C).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f9c55e7b8218c7d538e1d1a85e2e0c4
https://doi.org/10.1158/0008-5472.22391871.v1
https://doi.org/10.1158/0008-5472.22391871.v1
Autor:
Stefan Krauss, Huyen Dinh, Jennifer L. Dembinski, Olga Machonova, Jan Erik Paulsen, Dietmar Gradl, Doris Wedlich, Elsa Lundenes, Steven Ray Wilson, Jens Peter von Kries, Ondrej Machon, Jo Waaler
Supplementary Figure 6 from Novel Synthetic Antagonists of Canonical Wnt Signaling Inhibit Colorectal Cancer Cell Growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5014b558c557831ecf6941f02b7abc7d
https://doi.org/10.1158/0008-5472.22385946.v1
https://doi.org/10.1158/0008-5472.22385946.v1
Autor:
Stefan Krauss, Huyen Dinh, Jennifer L. Dembinski, Olga Machonova, Jan Erik Paulsen, Dietmar Gradl, Doris Wedlich, Elsa Lundenes, Steven Ray Wilson, Jens Peter von Kries, Ondrej Machon, Jo Waaler
Supplementary Figures 1-4 from Novel Synthetic Antagonists of Canonical Wnt Signaling Inhibit Colorectal Cancer Cell Growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f758cc070f621269a5c544ab264976f
https://doi.org/10.1158/0008-5472.22385931
https://doi.org/10.1158/0008-5472.22385931
Autor:
Stefan Krauss, Jens Peter von Kries, Andrey Voronkov, Dietmar Gradl, Olga Machonova, Tor J. Eide, Nina Marie Pedersen, Jan Erik Paulsen, Steven Ray Wilson, Vladimir Korinek, Huyen Dinh, Lucie Tumova, Ondrej Machon, Jo Waaler
PDF file - 178K, Pictures of the ileum (DMSO treated small intestine) that show delineated flat adenomas (A), with a few goblet cells (arrow)(B), a transition between normal epithelium and neoplastic glands (arrow) (C) and aberrant crypt foci in area
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45708a6de66c709581140e0f95354fe9
https://doi.org/10.1158/0008-5472.22391874.v1
https://doi.org/10.1158/0008-5472.22391874.v1