Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Dietlind L. Gerloff"'
Enzyme-assisted high throughput sequencing of an expanded genetic alphabet at single base resolution
Autor:
Bang Wang, Kevin M. Bradley, Myong-Jung Kim, Roberto Laos, Cen Chen, Dietlind L. Gerloff, Luran Manfio, Zunyi Yang, Steven A. Benner
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract With just four building blocks, low sequence information density, few functional groups, poor control over folding, and difficulties in forming compact folds, natural DNA and RNA have been disappointing platforms from which to evolve recepto
Externí odkaz:
https://doaj.org/article/025d698ec3364749b2c91f336ff28175
Autor:
Dietlind L. Gerloff, Elena I. Ilina, Camille Cialini, Uxue Mata Salcedo, Michel Mittelbronn, Tanja Müller
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 101905- (2023)
Summary: A significant number of proteins are annotated as functionally uncharacterized proteins. Within this protocol, we describe how to use protein family multiple sequence alignments and structural bioinformatics resources to design loss-of-funct
Externí odkaz:
https://doaj.org/article/97f3ec72c1fa4615ab273b26a6270375
Autor:
Elena I. Ilina, Camille Cialini, Dietlind L. Gerloff, Maitane Duarte Garcia-Escudero, Céline Jeanty, Marie-Laëtitia Thézénas, Antoine Lesur, Vincent Puard, François Bernardin, Alina Moter, Anne Schuster, Monika Dieterle, Anna Golebiewska, Jean-Jacques Gérardy, Gunnar Dittmar, Simone P. Niclou, Tanja Müller, Michel Mittelbronn
Publikováno v:
iScience, Vol 25, Iss 2, Pp 103842- (2022)
Summary: Glioblastoma (GBM) is the most aggressive primary brain tumor characterized by infiltrative growth of malignant glioma cells into the surrounding brain parenchyma. In this study, our analysis of GBM patient cohorts revealed a significantly h
Externí odkaz:
https://doaj.org/article/9391a4f387d04c32af06e8d9af82961b
Autor:
Helena Barysz, Ji Hun Kim, Zhuo Angel Chen, Damien F. Hudson, Juri Rappsilber, Dietlind L. Gerloff, William C. Earnshaw
Publikováno v:
Open Biology, Vol 5, Iss 2 (2015)
SMC proteins are essential components of three protein complexes that are important for chromosome structure and function. The cohesin complex holds replicated sister chromatids together, whereas the condensin complex has an essential role in mitotic
Externí odkaz:
https://doaj.org/article/cfecd24728e543ecaf2ab0ec2727a225
Publikováno v:
mBio, Vol 5, Iss 1 (2014)
ABSTRACT More than 20% of all protein domains are currently annotated as “domains of unknown function” (DUFs). About 2,700 DUFs are found in bacteria compared with just over 1,500 in eukaryotes. Over 800 DUFs are shared between bacteria and eukar
Externí odkaz:
https://doaj.org/article/16274d4b4b704f6fa2be7de04534a22c
Autor:
Dietlind L. Gerloff, Elena I. Ilina, Camille Cialini, Uxue Mata Salcedo, Michel Mittelbronn, Tanja Müller
Publikováno v:
STAR protocols. 4(1)
A significant number of proteins are annotated as functionally uncharacterized proteins. Within this protocol, we describe how to use protein family multiple sequence alignments and structural bioinformatics resources to design loss-of-function mutat
Autor:
Tanja R. Müller, Monika Dieterle, Jean-Jacques Gérardy, Anne Schuster, Michel Mittelbronn, Elena I. Ilina, Céline Jeanty, Maitane Duarte Garcia-Escudero, Camille Cialini, Simone P. Niclou, Alina Moter, Gunnar Dittmar, Dietlind L. Gerloff, Vincent Puard, Anna Golebiewska
Publikováno v:
SSRN Electronic Journal.
Glioblastoma (GBM) is the most aggressive primary brain tumor characterized by infiltrative migration of malignant glioma cells into the surrounding brain parenchyma. In this study, our analysis of GBM patient cohorts displayed significant higher exp
Autor:
Christian B. Winiger, Mariko F. Matsuura, Myong-Jung Kim, Steven A. Benner, Jennifer D. Moses, Shuichi Hoshika, Dietlind L. Gerloff, Ryan W. Shaw
Publikováno v:
Biochemistry
In addition to completing the Watson-Crick nucleobase matching "concept" (big pairs with small, hydrogen bond donors pair with hydrogen bond acceptors), artificially expanded genetic information systems (AEGIS) also challenge DNA polymerases with a c
Autor:
Dale S. Martin, Dietlind L. Gerloff, Geetha P. Bansal, Dibyadyuti Datta, Nirbhay Kumar, Mario T. Philipp, Brooke Grasperge, Drew Hannaman, Barry Ellefsen
Publikováno v:
Vaccine. 35(50)
Antibodies recognizing conformational epitopes in Pfs48/45, an antigen expressed on the surface of Plasmodium falciparum gametes and zygotes, have firmly established Pfs48/45 as a promising transmission blocking vaccine (TBV) candidate. However, it h
Autor:
Dietlind L. Gerloff, Dibyadyuti Datta, Geetha P. Bansal, Drew Hannaman, Nirbhay Kumar, Barry Ellefsen
Publikováno v:
Vaccine. 35(2)
Pfs48/45 and Pfs25 are leading candidates for the development of Plasmodium falciparum transmission blocking vaccines (TBV). Expression of Pfs48/45 in the erythrocytic sexual stages and presentation to the immune system during infection in the human