Výsledky vyhledávání - "Diethylnorspermine"

Phase 1 study of N 1,N 11-diethylnorspermine (DENSPM) in patients with advanced hepatocellular carcinoma

Autor: Emily Chan, Jeffrey W. Clark, Carl L. Berg, Amanda Carpenter, David P. Ryan, Scott J. Cotler, Douglas M. Heuman, Neil N. Senzer, Jordan Berlin, Keith Stuart, Jeffrey G. Supko, Sarah L. Hilderbrand, Aram F. Hezel, Lawrence S. Blaszkowsky, Lipika Goyal, Andrew X. Zhu

Publikováno v: Cancer Chemotherapy and Pharmacology. 72:1305-1314

N 1,N 11-diethylnorspermine (DENSPM), a synthetic analog of the naturally occurring polyamine spermine, can induce polyamine depletion and inhibit tumor cell growth. The objectives of this phase I study were to assess the safety, maximum-tolerated do

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48f07a6b1acb179806d01e7fe5770603
https://doi.org/10.1007/s00280-013-2293-8

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Inhibition of polyamine biosynthesis is a broad-spectrum strategy against RNA viruses

Publikováno v: Journal of Virology
Journal of Virology, 2016, 90 (21), pp.9683-9692. ⟨10.1128/JVI.01347-16⟩
Journal of Virology, American Society for Microbiology, 2016, 90 (21), pp.9683-9692. ⟨10.1128/JVI.01347-16⟩

RNA viruses present an extraordinary threat to human health, given their sudden and unpredictable appearance, the potential for rapid spread among the human population, and their ability to evolve resistance to antiviral therapies. The recent emergen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b99549b02c685e1b3e4c5f33cb0ff75
https://hal-pasteur.archives-ouvertes.fr/pasteur-01402012

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Overexpression of spermidine/spermine N 1-acetyltransferase or treatment with N 1-N 11-diethylnorspermine attenuates the severity of zinc-induced pancreatitis in mouse

Autor: Reijo Sironen, Anne Uimari, Leena Alhonen, Sini Pirnes-Karhu, Sirpa Peräniemi, Mari Merentie

Publikováno v: Amino Acids. 42:461-471

Depletion of pancreatic intracellular polyamine pools has been observed in acute pancreatitis both in the animal models and in humans. In this study, the wild-type mice, polyamine catabolic enzyme spermidine/spermine N(1)-acetyltransferase overexpres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e9baacf5e9832d1ae486a81ebdaf87
https://doi.org/10.1007/s00726-011-1025-9

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Activation of Polyamine Catabolism by N1,N11-Diethylnorspermine in Hepatic HepaRG Cells Induces Dedifferentiation and Mesenchymal-Like Phenotype

Autor: Olga N. Ivanova, Vladimir T. Valuev-Elliston, Olga A. Khomich, Alexander V. Ivanov, George S. Krasnov, Anna V. Kudryavtseva, Anastasiya V. Snezhkina, Tuomo A. Keinänen, Birke Bartosch, Sergey N. Kochetkov, Leena Alhonen, A. R. Khomutov

Publikováno v: Cells
Volume 7
Issue 12
Cells, Vol 7, Iss 12, p 275 (2018)

Tumorigenesis is accompanied by the metabolic adaptation of cells to support enhanced proliferation rates and to optimize tumor persistence and amplification within the local microenvironment. In particular, cancer cells exhibit elevated levels of bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeda904a878fa6a6df198719696cc07c
https://doi.org/10.3390/cells7120275

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Molecular mechanisms underlying N 1, N 11-diethylnorspermine-induced apoptosis in a human breast cancer cell line

Autor: C. Martina Holst, Johan Staaf, Stina Oredsson, Cecilia Hegardt, Göran Jönsson

Publikováno v: Anti-Cancer Drugs. 19:871-883

Polyamine analogue treatment results in growth inhibition and sometimes in cell death. Therefore, polyamine analogues are considered in the treatment of cancer; however, the cellular properties that govern sensitivity are not known. The objective of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbec00a5f148b23c93047c5966c77e18
https://doi.org/10.1097/cad.0b013e32830f902b

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Effect of the polyamine analogueN1,N11-diethylnorspermine on cell survival and susceptibility to apoptosis of human chondrocytes

Autor: Flavio Flamigni, Ivana Stanic, Silvia Cetrullo, Annalisa Facchini, Benedetta Tantini, Claudio Stefanelli, Rosa Maria Borzì, Carlo Guarnieri, Claudio Marcello Caldarera

Publikováno v: Journal of Cellular Physiology. 216:153-161

Chondrocyte survival is closely linked to cartilage integrity, and forms of chondrocyte apoptotic death can contribute to cartilage degeneration in articular diseases. Since growing evidence also implicates polyamines in the control of cell death, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::085aa8213661ffb46e4ace07cc997fee
https://doi.org/10.1002/jcp.21387

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Activation of polyamine catabolism by N1, N11-diethylnorspermine alters the cellular localization of mTOR and downregulates mTOR protein level in glioblastoma cells

Autor: Wei Zhang, Rongcai Jiang, Eugene W. Gerner, Stanley R. Hamilton, Limei Hu, Woonyoung Choi

Publikováno v: Cancer Biology & Therapy. 6:1644-1648

N(1), N(11)-Diethylnorspermine (DENSPM) is a spermine analog and prototype anti-cancer drug that depletes cellular polyamine, increases cellular oxidative stress through the generation of H(2)O(2) and induces the death of multiple types of cancer cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::563557ee639665f6dd89c16cc60e766a
https://doi.org/10.4161/cbt.6.10.4800

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Inhibition of cell proliferation and induction of apoptosis by N1,N11-diethylnorspermine-induced polyamine pool reduction

Autor: Veronica Johansson, Stina Oredsson, Kersti Alm, Erika Söderstjerna, C.M. Holst, Louise Myhre, E. Dahlberg

Publikováno v: Biochemical Society Transactions. 35:405-409

Reduction of cellular polyamine pools results in inhibition of cell proliferation and sometimes in induction of cell death. Reduction of cellular polyamine pools can be achieved by several strategies involving all the mechanisms of polyamine homoeost

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2722dc11c467f72ef1f5dbe95c4ec097
https://doi.org/10.1042/bst0350405

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Concentration-dependent effects ofN1,N11-diethylnorspermine on melanoma cell proliferation

Autor: Ajanthy Arulpragasam, Mirjana Fogel-Petrovic, Rodney F. Minchin, Samuel Knight

Publikováno v: International Journal of Cancer. 118:509-512

N1, N11-diethylnorspermine (DENSPM) is a polyamine analog that is currently under investigation as a novel anticancer drug. Although it has shown promising preclinical activity, there has been large variation in responsiveness reported between differ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8535c3d71442f7c9ed2373850676b313
https://doi.org/10.1002/ijc.21359

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Induction of spermidine/spermine N 1-acetyltransferase in breast cancer tissues treated with the polyamine analogue N 1,N 11-diethylnorspermine

Autor: Ellen Tully, Edward Gabrielson, Amy Hacker, Anthony E. Pegg, Robert A. Casero, Nancy E. Davidson

Publikováno v: Cancer Chemotherapy and Pharmacology. 54:122-126

The polyamine analogue, N 1,N 11-diethylnorspermine (DENSpm), is currently being evaluated in clinical trials for the treatment of solid tumors. The response of solid tumors to this drug has been associated with superinduction of the polyamine catabo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4821f14466c1718c363e4a344f80fdf1
https://doi.org/10.1007/s00280-004-0786-1

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