Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Diether Lambrecht"'
Publikováno v:
STAR Protocols, Vol 5, Iss 4, Pp 103270- (2024)
Summary: The spatial organization of cells within tissues aids in understanding physiological and pathological processes, as well as elucidating the mechanisms of action underlying treatments. We present a protocol for analyzing image-based spatial p
Externí odkaz:
https://doaj.org/article/b321d27bb7094632974ca7a92e3a7bbe
Autor:
Marta Piqué-Gili, Carmen Andreu-Oller, Agavni Mesropian, Roger Esteban-Fabró, Marina Bárcena-Varela, Marina Ruiz de Galarreta, Carla Montironi, Iris Martinez-Quetglas, Sarah Cappuyns, Judit Peix, Ieva Keraite, Albert Gris-Oliver, Elisa Fernández-Martínez, Ezequiel Mauro, Miguel Torres-Martin, Jordi Abril-Fornaguera, Katherine E. Lindblad, Diether Lambrechts, Jeroen Dekervel, Swan N. Thung, Daniela Sia, Amaia Lujambio, Roser Pinyol, Josep M. Llovet
Publikováno v:
JHEP Reports, Vol 6, Iss 11, Pp 101212- (2024)
Background & Aims: Transforming growth factor β (TGF-β) plays an oncogenic role in advanced cancer by promoting cell proliferation, metastasis and immunosuppression. PMEPA1 (prostate transmembrane protein androgen induced 1) has been shown to promo
Externí odkaz:
https://doaj.org/article/93d51b39e7c4419c83008f56aa023b9c
Autor:
Tom Venken, Ian S. Miller, Ingrid Arijs, Valentina Thomas, Ana Barat, Johannes Betge, Tianzuo Zhan, Timo Gaiser, Matthias P. Ebert, Alice C. O’Farrell, Jochen Prehn, Rut Klinger, Darran P. O’Connor, Brian Moulton, Verena Murphy, Garazi Serna, Paolo G. Nuciforo, Ray McDermott, Brian Bird, Gregory Leonard, Liam Grogan, Anne Horgan, Nadine Schulte, Markus Moehler, Diether Lambrechts, Annette T. Byrne
Publikováno v:
npj Genomic Medicine, Vol 9, Iss 1, Pp 1-10 (2024)
Abstract To predict outcome to combination bevacizumab (BVZ) therapy, we employed cell-free DNA (cfDNA) to determine chromosomal instability (CIN), nucleosome footprints (NF) and methylation profiles in metastatic colorectal cancer (mCRC) patients. L
Externí odkaz:
https://doaj.org/article/7492becf8fc3468584cbff1ca25b4e7f
Autor:
Tatjana Geukens, Maxim De Schepper, Wouter Van Den Bogaert, Karen Van Baelen, Marion Maetens, Anirudh Pabba, Amena Mahdami, Sophia Leduc, Edoardo Isnaldi, Ha-Linh Nguyen, Imane Bachir, Maysam Hajipirloo, Gitte Zels, Josephine Van Cauwenberge, Kristien Borremans, Vincent Vandecaveye, Birgit Weynand, Peter Vermeulen, Eleonora Leucci, Maria Francesca Baietti, George Sflomos, Laura Battista, Cathrin Brisken, Patrick W. B. Derksen, Thijs Koorman, Daan Visser, Colinda L. G. J. Scheele, Daniela S. Thommen, Sigrid Hatse, Sarah-Maria Fendt, Evy Vanderheyden, Thomas Van Brussel, Rogier Schepers, Bram Boeckx, Diether Lambrechts, Giuseppe Marano, Elia Biganzoli, Ann Smeets, Ines Nevelsteen, Kevin Punie, Patrick Neven, Hans Wildiers, François Richard, Giuseppe Floris, Christine Desmedt
Publikováno v:
npj Breast Cancer, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract Research on metastatic cancer has been hampered by limited sample availability. Here we present the breast cancer post-mortem tissue donation program UPTIDER and show how it enabled sampling of a median of 31 (range: 5-90) metastases and 5-8
Externí odkaz:
https://doaj.org/article/64acb1b4e34a40a5a3f7576042fa573b
Autor:
Frederik Peeters, Sarah Cappuyns, Marta Piqué-Gili, Gino Phillips, Chris Verslype, Diether Lambrechts, Jeroen Dekervel
Publikováno v:
JHEP Reports, Vol 6, Iss 7, Pp 101094- (2024)
Summary: Primary liver cancer, more specifically hepatocellular carcinoma (HCC), remains a significant global health problem associated with increasing incidence and mortality. Clinical, biological, and molecular heterogeneity are well-known hallmark
Externí odkaz:
https://doaj.org/article/3ecd1736b2c244978a0ba2bc4c8b06f3
Autor:
Dhanya Ramachandran, Jonathan P. Tyrer, Stefan Kommoss, Anna DeFazio, Marjorie J. Riggan, AOCS Group, Penelope M. Webb, Peter A. Fasching, Diether Lambrechts, María J. García, Cristina Rodríguez-Antona, Marc T. Goodman, Francesmary Modugno, Kirsten B. Moysich, Beth Y. Karlan, Jenny Lester, Susanne K. Kjaer, Allan Jensen, Estrid Høgdall, Ellen L. Goode, William A. Cliby, Amanika Kumar, Chen Wang, Julie M. Cunningham, Stacey J. Winham, Alvaro N. Monteiro, Joellen M. Schildkraut, Daniel W. Cramer, Kathryn L. Terry, Linda Titus, Line Bjorge, Liv Cecilie Vestrheim Thomsen, OPAL Study Group, Tanja Pejovic, Claus K. Høgdall, Iain A. McNeish, Taymaa May, David G. Huntsman, Jacobus Pfisterer, Ulrich Canzler, Tjoung-Won Park-Simon, Willibald Schröder, Antje Belau, Lars Hanker, Philipp Harter, Jalid Sehouli, Rainer Kimmig, Nikolaus de Gregorio, Barbara Schmalfeldt, Klaus Baumann, Felix Hilpert, Alexander Burges, Boris Winterhoff, Peter Schürmann, Lisa-Marie Speith, Peter Hillemanns, Andrew Berchuck, Sharon E. Johnatty, Susan J. Ramus, Georgia Chenevix-Trench, Paul D. P. Pharoah, Thilo Dörk, Florian Heitz
Publikováno v:
npj Genomic Medicine, Vol 9, Iss 1, Pp 1-12 (2024)
Abstract Survival from ovarian cancer depends on the resection status after primary surgery. We performed genome-wide association analyses for resection status of 7705 ovarian cancer patients, including 4954 with high-grade serous carcinoma (HGSOC),
Externí odkaz:
https://doaj.org/article/ac0253f401c44385bb41f701da028a0c
Autor:
Wout De Wispelaere, Daniela Annibali, Sandra Tuyaerts, Julie Messiaen, Asier Antoranz, Gautam Shankar, Nikolina Dubroja, Alejandro Herreros‐Pomares, Regina E. M. Baiden‐Amissah, Marie‐Pauline Orban, Marcello Delfini, Emanuele Berardi, Thomas Van Brussel, Rogier Schepers, Gino Philips, Bram Boeckx, Maria Francesca Baietti, Luigi Congedo, Kiave Yune HoWangYin, Emilie Bayon, Anne‐Sophie Van Rompuy, Eleonora Leucci, Sebastien P. Tabruyn, Francesca Bosisio, Massimiliano Mazzone, Diether Lambrechts, Frédéric Amant
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 5, Pp n/a-n/a (2024)
Abstract Background Uterine leiomyosarcomas (uLMS) are aggressive tumours with poor prognosis and limited treatment options. Although immune checkpoint blockade (ICB) has proven effective in some ‘challenging‐to‐treat’ cancers, clinical trial
Externí odkaz:
https://doaj.org/article/96c1f251d0ff4741b236139055f4119b
Autor:
Tuomo J Meretoja, Ruixian Liu, Diether Lambrechts, Johanna Mattson, Satu Mustjoki, Päivi Saavalainen, Bram Boeckx, Maija Hollmen, Rita Turpin, Pauliina M Munne, Aino Peura, Jenna H Rannikko, Gino Philips, Natasha Salmelin, Elina Hurskainen, Ilida Suleymanova, July Aung, Elisa M Vuorinen, Laura Lehtinen, Minna Mutka, Panu E Kovanen, Laura Niinikoski, Andrei Goga, Jeroen Pouwels, Juha Klefström
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 4 (2024)
Background Combining cytotoxic chemotherapy or novel anticancer drugs with T-cell modulators holds great promise in treating advanced cancers. However, the response varies depending on the tumor immune microenvironment (TIME). Therefore, there is a c
Externí odkaz:
https://doaj.org/article/cffa2828cea442bea9cecbc2dda3a9f7
Autor:
Sarah Cappuyns, Gino Philips, Vincent Vandecaveye, Bram Boeckx, Rogier Schepers, Thomas Van Brussel, Ingrid Arijs, Aurelie Mechels, Ayse Bassez, Francesca Lodi, Joris Jaekers, Halit Topal, Baki Topal, Orian Bricard, Junbin Qian, Eric Van Cutsem, Chris Verslype, Diether Lambrechts, Jeroen Dekervel
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The combination of atezolizumab plus bevacizumab (atezo/bev) has dramatically changed the treatment landscape of advanced HCC (aHCC), achieving durable responses in some patients. Using single-cell transcriptomics, we characterize the intra-
Externí odkaz:
https://doaj.org/article/db4b12030ddd4fd095ec4bcc29c92ddb
Autor:
Jelle Verhoeven, Kathryn A Jacobs, Francesca Rizzollo, Francesca Lodi, Yichao Hua, Joanna Poźniak, Adhithya Narayanan Srinivasan, Diede Houbaert, Gautam Shankar, Sanket More, Marco B Schaaf, Nikolina Dubroja Lakic, Maarten Ganne, Jochen Lamote, Johan Van Weyenbergh, Louis Boon, Oliver Bechter, Francesca Bosisio, Yasuo Uchiyama, Mathieu JM Bertrand, Jean Christophe Marine, Diether Lambrechts, Gabriele Bergers, Madhur Agrawal, Patrizia Agostinis
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 12, Pp 1-25 (2023)
Abstract Tumor endothelial cells (TECs) actively repress inflammatory responses and maintain an immune‐excluded tumor phenotype. However, the molecular mechanisms that sustain TEC‐mediated immunosuppression remain largely elusive. Here, we show t
Externí odkaz:
https://doaj.org/article/bbcea8700d3946d0a54b3724c68d12c4