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pro vyhledávání: '"Dieter Schwarz"'
Autor:
Dieter Schwarz
Publikováno v:
October. 124:157-168
OCTOBER 124, Spring 2008, pp. 157–168 © 2008 October Magazine, Ltd. and Massachusetts Institute of Technology. It is difficult to provide a clear idea of the work of Marisa Merz as a whole, for inasmuch as it has been presented to the public only
Publikováno v:
Cancer Research. 65:2972-2978
Several epidemiologic studies associate certain CYP1A1 genotypes, alone or in combination, with an increased risk of estrogen-related cancers. To answer the question of whether genotype-dependent activation of estrogens by CYP1A1 could be the underly
Publikováno v:
Handbook of Toxicogenomics: Strategies and Applications
Autor:
Spencer S. Ericksen, Horst Honeck, Dieter Schwarz, Pyotr Kisselev, Wolf-Hagen Schunck, Grazyna D. Szklarz, Alexey Chernogolov, Ivar Roots
Publikováno v:
Biochemical Pharmacology. 67:1445-1457
Human cytochrome P450 1A1 (CYP1A1) and human NADPH-cytochrome P450 reductase were expressed and purified from Spodoptera frugiperda insect cells. A reconstituted enzymatically active system metabolized polyunsaturated fatty acids such as arachidonic
Autor:
Dieter Schwarz, Ivar Roots
Publikováno v:
Biochemical and Biophysical Research Communications. 303:902-907
Previously, inhibitors of CYP1A1 were rated as candidate chemopreventive agents against cancer mainly according to their effects on the 7-ethoxyresorufin O-deethylation (EROD) of diagnostic probe substrates. Surprisingly, several polyphenols includin
Publikováno v:
Protein Expression and Purification. 28:259-269
Three human cytochrome P450 1A1 (CYP1A1) allelic variants, namely wild-type (CYP1A1.1), CYP1A1.2 (I462V), and CYP1A1.4 (T461N), were expressed as C-terminal His-tagged fusions including a thrombin cleavage site in Spodoptera frugiperda insect cells b
Publikováno v:
Xenobiotica. 31:345-356
1. Three human cytochrome P4501A1 (CYP1A1) variants, wild-type (CYP1A1.1), CYP1A1.2 (1462V) and CYP1A1.4 (T461N), were co-expressed with human NADPH-P450 reductase (OR) in Spodoptera frugiperda (Sf9) insect cells by baculovirus co-infection to elabor
Publikováno v:
European Journal of Biochemistry. 267:2909-2915
We studied the properties of a series of phosphatidylcholine molecules with branched acyl chains. These lipids have previously been shown to have marked stimulatory effects on the side-chain cleavage activity of cytochrome P450SCC (CYP11A1), an enzym
Autor:
Pyotr Kisselev, Rolf D. Schmid, Uwe T. Bornscheuer, Sandra Pisch, Wolfgang Pfeil, Dieter Schwarz
Publikováno v:
Biochemistry. 36:14262-14270
To analyze whether specific protein-lipid interactions or physical features of the membrane contribute to cytochrome P450SCC (CYP11A1) activation by lipids, dimyristoylphosphatidylcholine/cardiolipin and dimyristoylphosphatidylcholine/branched phosph
Publikováno v:
Chemistry and Physics of Lipids. 85:91-99
Phosphatidylcholines with saturated branched fatty acyl chains substituted in the 2-positions of the main chains have a significant stimulating effect on both the side chain cleavage activity of cytochrome P450SCC and the ability of P450SCC to induce