Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Dieter Schmoll"'
Autor:
Dieter Schmoll, Nicole Ziegler, Benoit Viollet, Marc Foretz, Patrick C. Even, Dalila Azzout‐Marniche, Andreas Nygaard Madsen, Martin Illemann, Karen Mandrup, Michael Feigh, Jörg Czech, Heiner Glombik, Jacob A. Olsen, Wolfgang Hennerici, Klaus Steinmeyer, Ralf Elvert, Tamara R. Castañeda, Aimo Kannt
Publikováno v:
Hepatology Communications, Vol 4, Iss 7, Pp 1056-1072 (2020)
The worldwide obesity and type 2 diabetes epidemics have led to an increase in nonalcoholic fatty liver disease (NAFLD). NAFLD covers a spectrum of hepatic pathologies ranging from simple steatosis to nonalcoholic steatohepatitis, characterized by fi
Externí odkaz:
https://doaj.org/article/9426e7d8200a4cacaf75487e613184ae
Autor:
Yann W. Yap, Patricia M. Rusu, Andrea Y. Chan, Barbara C. Fam, Andreas Jungmann, Samantha M. Solon-Biet, Christopher K. Barlow, Darren J. Creek, Cheng Huang, Ralf B. Schittenhelm, Bruce Morgan, Dieter Schmoll, Bente Kiens, Matthew D. W. Piper, Mathias Heikenwälder, Stephen J. Simpson, Stefan Bröer, Sofianos Andrikopoulos, Oliver J. Müller, Adam J. Rose
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Dietary protein dilution, where protein is reduced and replaced by other nutrient sources without caloric restriction, promotes metabolic health via the hepatokine Fgf21. Here, the authors show that essential amino acids threonine and tryptophan are
Externí odkaz:
https://doaj.org/article/36856bb21e41464a998b62244a235694
Autor:
Adriano Maida, Jessica S.K. Chan, Kim A. Sjøberg, Annika Zota, Dieter Schmoll, Bente Kiens, Stephan Herzig, Adam J. Rose
Publikováno v:
Molecular Metabolism, Vol 6, Iss 8, Pp 873-881 (2017)
Objective: Dietary protein dilution (PD) has been associated with metabolic advantages such as improved glucose homeostasis and increased energy expenditure. This phenotype involves liver-induced release of FGF21 in response to amino acid insufficien
Externí odkaz:
https://doaj.org/article/f6363aa7cf6240e9b95f8b776bf5df2e
Autor:
Sebastian Brachs, Angelika F. Winkel, Hui Tang, Andreas L. Birkenfeld, Bodo Brunner, Kerstin Jahn-Hofmann, Daniel Margerie, Hartmut Ruetten, Dieter Schmoll, Joachim Spranger
Publikováno v:
Molecular Metabolism, Vol 5, Iss 11, Pp 1072-1082 (2016)
Objective: Non-alcoholic fatty liver disease is a world-wide health concern and risk factor for cardio-metabolic diseases. Citrate uptake modifies intracellular hepatic energy metabolism and is controlled by the conserved sodium-dicarboxylate cotrans
Externí odkaz:
https://doaj.org/article/e5e65e2ccada43378f7614a3e68e2670
Publikováno v:
Nutrients, Vol 12, Iss 8, p 2195 (2020)
Pre-clinical studies show that dietary protein restriction (DPR) improves healthspan and retards many age-related diseases such as type 2 diabetes. While mouse studies have shown that restriction of certain essential amino acids is required for this
Externí odkaz:
https://doaj.org/article/ebeed9d2abb941bc9e4f3f0560366bf7
Autor:
Yang Jiang, Adam J. Rose, Tjeerd P. Sijmonsma, Angelika Bröer, Anja Pfenninger, Stephan Herzig, Dieter Schmoll, Stefan Bröer
Publikováno v:
Molecular Metabolism, Vol 4, Iss 5, Pp 406-417 (2015)
Objective: Type 2 diabetes arises from insulin resistance of peripheral tissues followed by dysfunction of β-cells in the pancreas due to metabolic stress. Both depletion and supplementation of neutral amino acids have been discussed as strategies t
Externí odkaz:
https://doaj.org/article/33f1cb22266c469b948b7aa7cf9df073
Autor:
Sebastian Brachs, Angelika F Winkel, James Polack, Hui Tang, Maria Brachs, Daniel Margerie, Bodo Brunner, Kerstin Jahn-Hofmann, Hartmut Ruetten, Joachim Spranger, Dieter Schmoll
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0172657 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0166110.].
Externí odkaz:
https://doaj.org/article/076f5bf6ca3c49c4b9a951ee5c1b36f7
Autor:
Sebastian Brachs, Angelika F Winkel, James Polack, Hui Tang, Maria Brachs, Daniel Margerie, Bodo Brunner, Kerstin Jahn-Hofmann, Hartmut Ruetten, Joachim Spranger, Dieter Schmoll
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166110 (2016)
The transcription factor NF-E2-related factor 2 (Nrf2) induces cytoprotective genes, but has also been linked to the regulation of hepatic energy metabolism. In order to assess the pharmacological potential of hepatic Nrf2 activation in metabolic dis
Externí odkaz:
https://doaj.org/article/83030c9dcb7343af9651ba7750e146b5
Autor:
Marie-Sophie Nguyen-Tu, Joseph Harris, Aida Martinez-Sanchez, Pauline Chabosseau, Ming Hu, Eleni Georgiadou, Alice Pollard, Pablo Otero, Livia Lopez-Noriega, Isabelle Leclerc, Kei Sakamoto, Dieter Schmoll, David M. Smith, David Carling, Guy A. Rutter
Publikováno v:
Nguyen-Tu, M-S, Harris, J, Martinez-Sanchez, A, Chabosseau, P, Hu, M, Georgiadou, E, Pollard, A, Otero, P, Lopez-Noriega, L, Leclerc, I, Sakamoto, K, Schmoll, D, Smith, D M, Carling, D & Rutter, G A 2022, ' Opposing effects on regulated insulin secretion of acute vs chronic stimulation of AMP-activated protein kinase ', Diabetologia, vol. 65, pp. 997-1011 . https://doi.org/10.1007/s00125-022-05673-x
Aims/hypothesis Although targeted in extrapancreatic tissues by several drugs used to treat type 2 diabetes, the role of AMP-activated protein kinase (AMPK) in the control of insulin secretion is still debatable. Previous studies have used pharmacolo
Autor:
Paulus Wohlfart, Michael Feigh, Sanne Skovgård Veidal, Dieter Schmoll, Aimo Kannt, Andreas Nygaard Madsen
Publikováno v:
British Journal of Pharmacology. 178:2412-2423
Background and purpose Activation of hepatic thyroid hormone receptor β (THR-β) is associated with systemic lipid lowering, increased bile acid synthesis, and fat oxidation. In patients with non-alcoholic steatohepatitis (NASH), treatment with THR-