Zobrazeno 1 - 10
of 600
pro vyhledávání: '"Dieter Söll"'
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/49e884b363034667937876545cf537f9
Autor:
Han-Kai Jiang, Jui-Hung Weng, Yi-Hui Wang, Jo-Chu Tsou, Pei-Jung Chen, An-Li Andrea Ko, Dieter Söll, Ming-Daw Tsai, Yane-Shih Wang
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Once thought to be non-naturally occurring, D-amino acids (DAAs) have in recent years been revealed to play a wide range of physiological roles across the tree of life, including in human systems. Synthetic biologists have since exploited DAAs’ uni
Externí odkaz:
https://doaj.org/article/7b5888d861c84aa784a5ab099ea304c4
Autor:
Pearl Morosky, Cody Comyns, Lance G. A. Nunes, Christina Z. Chung, Peter R. Hoffmann, Dieter Söll, Oscar Vargas-Rodriguez, Natalie Krahn
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Post-translational modifications (PTMs) can occur on almost all amino acids in eukaryotes as a key mechanism for regulating protein function. The ability to study the role of these modifications in various biological processes requires techniques to
Externí odkaz:
https://doaj.org/article/11feafb19d6744eebafcd976e48d9b77
Publikováno v:
Frontiers in Catalysis, Vol 2 (2022)
Hydrogen is a clean, renewable energy source, that when combined with oxygen, produces heat and electricity with only water vapor as a biproduct. Furthermore, it has the highest energy content by weight of all known fuels. As a result, various strate
Externí odkaz:
https://doaj.org/article/1a37f37037de40c38fee2f7ad1517c4e
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Genetic code expansion strategies are limited to specific codons that can be reassigned to new amino acids. Here the authors show that quadruplet-decoding tRNAs (qtRNAs) can be rapidly discovered and evolved to decode new quadruplet codons, enabling
Externí odkaz:
https://doaj.org/article/160d7d8ec84743218f1d2a710d9af0a0
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Archaea constitute the third domain of life, distinct from bacteria and eukaryotes given their ability to tolerate extreme environments. To survive these harsh conditions, certain archaeal lineages possess unique genetic code systems to encode either
Externí odkaz:
https://doaj.org/article/5d01ad1513074ef2ac79b8f5ff9817e2
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Intricate evolutionary events enabled the emergence of the full set of aminoacyl-tRNA synthetase (aaRS) families that define the genetic code. The diversification of aaRSs has continued in organisms from all domains of life, yielding aaRSs with uniqu
Externí odkaz:
https://doaj.org/article/8db45cafa9be4d14a2fe6a8e6fecc728
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Pyrrolysyl-tRNA synthetase (PylRS) is frequently used for site-specific incorporation of noncanonical amino acids (ncAAs) into proteins. Recently, the active site of Methanomethylophilus alvus PylRS (MaPylRS) has been rationally engineered to expand
Externí odkaz:
https://doaj.org/article/285e9b38bd354e33b0d15f3d417585a0
Publikováno v:
eLife, Vol 11 (2022)
Translation using four-base codons occurs in both natural and synthetic systems. What constraints contributed to the universal adoption of a triplet codon, rather than quadruplet codon, genetic code? Here, we investigate the tolerance of the Escheric
Externí odkaz:
https://doaj.org/article/cf4f2d3af00a4ed6b14e78b5ff4762bf
Publikováno v:
Frontiers in Genetics, Vol 12 (2022)
Universally present aminoacyl-tRNA synthetases (aaRSs) stringently recognize their cognate tRNAs and acylate them with one of the proteinogenic amino acids. However, some organisms possess aaRSs that deviate from the accurate translation of the genet
Externí odkaz:
https://doaj.org/article/82a0b61149324758a2f752aa7cbbe010